National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6815

TDMS Study 96010-04 Pathology Tables

NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04

                                                          FINAL#1/MICE




       Facility:  Southern Research Institute

       Chemical CAS #:  7775-09-9

       Lock Date:  10/16/01

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All

































a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)

                                                              Page   1


NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     10           10           12            7                                     
    Moribund Sacrifice                                 3            5            6            8                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           34           31           35                                     
    Moribund Sacrifice                                              1                                                               
  Other                                                                          1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (48)         (49)                                   
      Hemorrhage                                       1 [3.0]                                                                      
   Intestine Large, Cecum                             (44)         (47)         (47)         (47)                                   
      Edema                                            4 [2.0]      6 [2.0]      6 [2.2]      6 [1.8]                               
      Hemorrhage                                       1 [4.0]                                                                      
      Inflammation, Chronic                                                      1 [3.0]                                            
      Ulcer                                                                      1 [3.0]                                            
   Intestine Small, Duodenum                          (46)         (47)         (47)         (50)                                   
      Ulcer                                                         1 [4.0]      1 [2.0]                                            
      Epithelium, Hyperplasia                                                    2 [2.5]                                            
   Intestine Small, Ileum                             (42)         (45)         (46)         (47)                                   
      Inflammation, Chronic                                                      1 [2.0]      1 [3.0]                               
      Epithelium, Hyperplasia                                                    1 [2.0]      1 [2.0]                               
   Liver                                              (49)         (50)         (49)         (50)                                   
      Angiectasis                                      2 [2.0]                   2 [3.5]      1 [3.0]                               
      Basophilic Focus                                 5                         4            1                                     
      Clear Cell Focus                                 3                         1                                                  
      Eosinophilic Focus                               9            9           13            7                                     
      Hematopoietic Cell Proliferation                 7 [2.1]      4 [2.5]      3 [2.7]      8 [2.3]                               
      Hemorrhage                                                                 1 [2.0]                                            
      Hepatodiaphragmatic Nodule                                    1                                                               
      Hyperplasia, Lymphoid                            4 [2.0]      7 [2.1]      3 [2.0]      5 [2.0]                               
      Infarct                                                       1 [3.0]                                                         
      Infiltration Cellular, Mixed Cell                7 [1.9]      7 [1.6]      8 [1.9]      7 [2.1]                               
      Mixed Cell Focus                                 7            2            3            3                                     
      Necrosis, Focal                                  5 [1.8]      1 [1.0]      4 [2.0]      1 [3.0]                               
      Tension Lipidosis                                2            3                         1                                     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Necrosis                          2 [2.5]      2 [3.5]      2 [2.5]      2 [3.0]                               
      Hepatocyte, Karyomegaly                                                                 3 [2.3]                               
      Hepatocyte, Vacuolization Cytoplasmic            4 [3.3]      3 [3.3]      6 [3.0]      4 [3.5]                               
      Kupffer Cell, Hyperplasia                                     1 [3.0]      1 [2.0]      2 [3.0]                               
      Kupffer Cell, Pigmentation                       3 [2.0]      4 [2.3]      4 [1.8]      7 [2.3]                               
   Mesentery                                          (30)         (32)         (27)         (24)                                   
      Angiectasis                                      1 [3.0]                                1 [3.0]                               
      Hemorrhage                                       1 [4.0]                                                                      
      Inflammation, Chronic                                                                   1 [3.0]                               
      Fat, Necrosis                                   21 [3.0]     24 [3.1]     20 [3.6]     16 [3.3]                               
   Pancreas                                           (46)         (47)         (49)         (48)                                   
      Atrophy                                          2 [2.5]      1 [4.0]                   1 [1.0]                               
      Cyst                                                          1 [3.0]      1 [3.0]                                            
      Acinus, Hyperplasia, Focal                                                              1 [2.0]                               
   Salivary Glands                                    (48)         (47)         (49)         (50)                                   
      Hyperplasia, Lymphoid                           16 [2.3]     21 [2.2]     15 [2.4]     18 [2.3]                               
   Stomach, Forestomach                               (49)         (50)         (50)         (49)                                   
      Diverticulum                                     2            1            1            2                                     
      Edema                                                                      3 [2.7]                                            
      Erosion                                                       1 [2.0]      2 [2.5]      2 [1.5]                               
      Hyperplasia                                      1 [1.0]                                                                      
      Inflammation, Chronic Active                                               2 [1.5]      2 [2.0]                               
      Ulcer                                            2 [2.5]                   3 [2.3]      3 [2.3]                               
      Epithelium, Hyperplasia                          3 [2.3]      4 [2.0]      9 [2.4]      6 [2.2]                               
   Stomach, Glandular                                 (49)         (48)         (50)         (49)                                   
      Erosion                                                       1 [3.0]      2 [2.5]                                            
      Ulcer                                                                      1 [3.0]                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)          (3)                       (1)                                    
      Aorta, Mineralization                                         1 [4.0]                                                         
   Heart                                              (49)         (50)         (49)         (50)                                   
      Cardiomyopathy                                   1 [2.0]      1 [2.0]      1 [2.0]                                            
      Mineralization                                   1 [2.0]                   1 [2.0]      2 [3.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (49)         (49)         (50)                                   
      Accessory Adrenal Cortical Nodule                4 [3.0]      2 [3.0]      7 [3.0]      7 [3.0]                               
      Hyperplasia, Focal                                                         1 [2.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Capsule, Hyperplasia                                                       1 [2.0]      2 [2.0]                               
      Zona Reticularis, Vacuolization Cytoplasmic                                1 [3.0]      1 [3.0]                               
   Adrenal Medulla                                    (50)         (49)         (49)         (50)                                   
      Hyperplasia                                      2 [1.0]                   2 [1.5]      1 [1.0]                               
   Islets, Pancreatic                                 (46)         (47)         (49)         (49)                                   
      Hyperplasia                                      9 [1.7]      6 [2.0]      4 [2.3]      3 [2.0]                               
   Parathyroid Gland                                  (45)         (47)         (48)         (47)                                   
      Cyst                                             1 [2.0]      1 [3.0]      2 [2.5]      2 [3.0]                               
   Pituitary Gland                                    (46)         (45)         (48)         (50)                                   
      Pars Distalis, Angiectasis                       1 [1.0]      2 [2.5]      2 [1.5]                                            
      Pars Distalis, Cyst                                                                     1 [3.0]                               
      Pars Distalis, Hyperplasia, Focal                3 [1.7]      3 [2.3]      3 [2.7]      1 [3.0]                               
   Thyroid Gland                                      (48)         (50)         (49)         (50)                                   
      Degeneration, Cystic                            25 [2.3]     28 [2.1]     34 [2.5]     32 [2.3]                               
      Follicle, Cyst                                   1            1                         1                                     
      Follicular Cell, Cyst                                                                   2                                     
      Follicular Cell, Hypertrophy                     3 [1.3]      2 [2.0]      5 [1.0]     14 [1.4]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (47)         (47)         (49)                                   
      Inflammation, Chronic                                         2 [2.0]                   4 [2.3]                               
   Ovary                                              (45)         (45)         (47)         (50)                                   
      Angiectasis                                      3 [3.0]      2 [3.0]      4 [2.5]      3 [2.7]                               
      Cyst                                             9           14           14           13                                     
      Cyst, Hemorrhagic                                1                                                                            
      Hemorrhage                                       1 [2.0]                                                                      
      Thrombosis                                       3            1            1                                                  
      Bilateral, Cyst                                               1                                                               
      Follicle, Hemorrhage                             1 [2.0]      4 [3.0]      4 [2.3]      9 [2.2]                               
      Granulosa Cell, Hyperplasia                                                3 [2.7]      7 [2.6]                               
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [2.0]                   2 [3.5]      1 [4.0]                               
      Hyperplasia, Atypical                                         1 [3.0]                                                         
      Hyperplasia, Cystic                             45 [3.1]     45 [3.2]     40 [3.1]     41 [3.1]                               
      Inflammation, Chronic                                                      2 [2.5]                                            
      Inflammation, Suppurative                        1 [4.0]                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Metaplasia, Squamous                                          2 [2.5]      1 [2.0]                                            
      Endometrium, Hyperplasia, Atypical                            1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hyperplasia                                     14 [2.4]     28 [2.6]     29 [2.9]     31 [2.7]                               
      Myelofibrosis                                    1 [3.0]      2 [3.5]      1 [4.0]      2 [2.0]                               
   Lymph Node                                         (7)          (5)          (11)         (9)                                    
      Iliac, Hemorrhage                                                          1 [3.0]                                            
      Iliac, Hyperplasia, Lymphoid                     1 [3.0]                                1 [3.0]                               
      Mediastinal, Hyperplasia, Lymphoid               1 [3.0]      1 [3.0]      2 [3.5]                                            
      Mediastinal, Pigmentation                        1 [2.0]                                                                      
      Pancreatic, Hemorrhage                                                                  1 [4.0]                               
      Renal, Hemorrhage                                1 [4.0]                                1 [3.0]                               
   Lymph Node, Mandibular                             (46)         (46)         (49)         (49)                                   
      Atrophy                                                       1 [3.0]                   1 [3.0]                               
      Hematopoietic Cell Proliferation                              1 [2.0]      1 [2.0]      1 [2.0]                               
      Hyperplasia, Lymphoid                           12 [2.7]      7 [2.4]      7 [2.3]     10 [2.8]                               
      Pigmentation                                    18 [2.4]     16 [2.6]     18 [2.2]     15 [2.3]                               
   Lymph Node, Mesenteric                             (47)         (49)         (49)         (49)                                   
      Atrophy                                          1 [3.0]      1 [3.0]                   2 [2.5]                               
      Ectasia                                          2 [3.0]                                1 [3.0]                               
      Hematopoietic Cell Proliferation                 2 [2.0]      2 [2.5]      1 [2.0]      2 [2.0]                               
      Hemorrhage                                       4 [3.3]      2 [4.0]                   1 [2.0]                               
      Hyperplasia, Lymphoid                           10 [2.6]      8 [2.1]     11 [2.8]      6 [2.5]                               
      Pigmentation                                     1 [2.0]      2 [2.5]                                                         
   Spleen                                             (49)         (48)         (49)         (50)                                   
      Accessory Spleen                                                                        1                                     
      Hematopoietic Cell Proliferation                39 [2.5]     39 [2.8]     35 [2.8]     39 [2.8]                               
      Hyperplasia, Lymphoid                           11 [2.6]     10 [2.3]      5 [3.0]      9 [2.4]                               
      Pigmentation                                    28 [2.4]     30 [2.6]     28 [2.6]     27 [2.6]                               
      Lymphoid Follicle, Atrophy                       1 [3.0]      2 [2.5]      1 [3.0]      2 [3.0]                               
   Thymus                                             (48)         (44)         (48)         (48)                                   
      Atrophy                                          5 [3.0]      7 [2.9]      5 [3.0]      9 [2.9]                               
      Cyst                                             3 [3.0]                   1 [3.0]      1 [3.0]                               
      Hyperplasia, Lymphoid                            5 [2.8]      3 [2.7]      4 [3.0]      2 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Hyperplasia                                      5 [1.4]     11 [1.5]      8 [1.9]     10 [1.4]                               
   Skin                                               (48)         (50)         (50)         (50)                                   
      Edema                                                         1 [3.0]                   1 [3.0]                               
      Epidermis, Hyperplasia                           1 [2.0]                                1 [4.0]                               
      Subcutaneous Tissue, Edema                                                 1 [4.0]      2 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Callus                                           1 [4.0]                                                                      
      Fracture                                                                   1            1                                     
      Hyperostosis                                     1 [3.0]      1 [2.0]      4 [2.0]      3 [2.0]                               
      Cranium, Osteopetrosis                                                     1 [3.0]                                            
      Femur, Osteopetrosis                                          1 [2.0]      1 [3.0]                                            
   Skeletal Muscle                                                 (2)          (4)          (6)                                    
      Angiectasis                                                                             1 [3.0]                               
      Atrophy                                                                                 1 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                      1 [4.0]                   1 [3.0]      1 [4.0]                               
      Inflammation, Chronic                                                                   1 [2.0]                               
      Necrosis                                                                   1 [2.0]      1 [3.0]                               
   Peripheral Nerve                                                             (2)          (2)                                    
      Atrophy                                                                    1 [2.0]      2 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (50)                                   
      Edema                                            5 [2.0]      8 [2.1]      3 [2.0]      5 [2.0]                               
      Foreign Body                                     2                                                                            
      Hemorrhage                                       5 [1.4]      8 [1.8]      6 [2.0]      4 [2.3]                               
      Hyperplasia, Lymphoid                           10 [2.0]      8 [2.1]      3 [2.3]      9 [2.1]                               
      Infiltration Cellular, Polymorphonuclear                      1 [3.0]                                                         
      Infiltration Cellular, Histiocyte                1 [2.0]      1 [4.0]      3 [2.3]      5 [2.0]                               
      Metaplasia, Osseous                                           1 [1.0]      2 [1.0]                                            
      Thrombosis                                       1 [2.0]      4 [2.3]      1 [3.0]                                            
      Alveolar Epithelium, Hyperplasia                 2 [2.0]      2 [1.5]      1 [1.0]      2 [1.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                           0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (48)         (50)         (50)                                   
      Inflammation, Chronic                            3 [2.3]      3 [2.3]                                                         
      Cornea, Hyperplasia                              2 [3.0]      1 [2.0]                                                         
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Cyst                                                                                    1 [3.0]                               
      Hyperplasia, Focal                               1 [2.0]      1 [1.0]                   1 [2.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Hydronephrosis                                                             1 [3.0]      1 [3.0]                               
      Hyperplasia, Lymphoid                            8 [2.1]      9 [2.1]      6 [2.2]      8 [2.1]                               
      Infarct                                          3 [2.0]      2 [2.5]      4 [1.8]      5 [1.8]                               
      Metaplasia, Osseous                                           1 [1.0]      3 [1.3]      2 [1.5]                               
      Nephropathy                                     14 [1.3]     11 [1.4]     14 [1.6]     12 [1.4]                               
      Renal Tubule, Accumulation, Hyaline Droplet      2 [2.5]      1 [2.0]      2 [2.5]      1 [3.0]                               
      Renal Tubule, Dilatation                         1 [3.0]                                1 [3.0]                               
      Renal Tubule, Necrosis                           1 [3.0]                                1 [3.0]                               
      Renal Tubule, Pigmentation                       3 [2.3]      1 [2.0]                   1 [2.0]                               
      Transitional Epithelium, Hyperplasia             1 [1.0]                                                                      
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Hyperplasia, Lymphoid                            4 [2.0]     12 [2.4]      4 [2.0]      5 [2.0]                               
      Transitional Epithelium, Hyperplasia                                       1 [3.0]                                            
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7            4            5            7                                     
    Moribund Sacrifice                                 5            5            4           10                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           41           41           33                                     
                                                                                                                                    
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (49)         (49)         (48)                                   
      Edema                                            1 [2.0]      3 [2.0]      4 [2.0]      2 [2.0]                               
      Inflammation, Chronic                                         1 [3.0]                   1 [2.0]                               
   Intestine Small, Duodenum                          (48)         (50)         (49)         (49)                                   
      Ulcer                                                         1 [2.0]      1 [4.0]                                            
      Epithelium, Hyperplasia                                                    1 [2.0]      1 [3.0]                               
   Intestine Small, Jejunum                           (47)         (49)         (50)         (50)                                   
      Epithelium, Hyperplasia                                                                 2 [2.5]                               
   Intestine Small, Ileum                             (47)         (49)         (49)         (49)                                   
      Cyst                                                          1 [3.0]                                                         
   Liver                                              (48)         (50)         (50)         (50)                                   
      Angiectasis                                      2 [2.5]      2 [1.5]                                                         
      Basophilic Focus                                              2            3            4                                     
      Clear Cell Focus                                12           19           19           13                                     
      Cyst                                                                       1 [2.5]      1 [3.0]                               
      Eosinophilic Focus                              11           10            5           11                                     
      Hematopoietic Cell Proliferation                 1 [3.0]                                4 [2.0]                               
      Hemorrhage                                       1 [3.0]      1 [2.0]                                                         
      Hyperplasia, Lymphoid                                         1 [2.0]      1 [2.0]                                            
      Infarct                                                                    1 [2.0]                                            
      Infiltration Cellular, Mixed Cell                2 [1.5]      1 [2.0]      1 [1.0]                                            
      Mixed Cell Focus                                 2            9            8            7                                     
      Necrosis, Focal                                  4 [2.3]      6 [2.8]      7 [2.3]      6 [3.2]                               
      Regeneration, Focal                                                        1 [2.0]                                            
      Tension Lipidosis                                1                         1                                                  
      Bile Duct, Hyperplasia                                                                  2 [2.0]                               
      Centrilobular, Necrosis                          1 [3.0]                                2 [3.0]                               
      Hepatocyte, Karyomegaly                                                    1 [2.0]      1 [2.0]                               
      Hepatocyte, Vacuolization Cytoplasmic            2 [3.0]                                3 [2.7]                               
      Kupffer Cell, Pigmentation                       2 [4.0]                   1 [4.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    8                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (9)          (10)         (10)         (8)                                    
      Infarct                                                                    1                                                  
      Inflammation, Chronic                            1 [3.0]                                2 [4.0]                               
      Fat, Necrosis                                    3 [3.7]      8 [3.1]      6 [3.2]      5 [3.2]                               
   Pancreas                                           (48)         (50)         (50)         (50)                                   
      Cyst                                                                                    2 [3.0]                               
      Acinus, Cytoplasmic Alteration                                             1 [3.0]      1 [3.0]                               
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 [2.0]      2 [2.0]                               
      Hyperplasia, Lymphoid                            7 [2.3]      3 [2.0]      6 [2.0]      4 [2.0]                               
   Stomach, Forestomach                               (49)         (50)         (50)         (50)                                   
      Cyst                                             2                                                                            
      Diverticulum                                     1            1                         2                                     
      Erosion                                                       1 [2.0]                                                         
      Inflammation, Chronic Active                     2 [3.0]      2 [2.5]      4 [1.8]      2 [2.0]                               
      Ulcer                                            1 [3.0]      1 [2.0]      2 [2.0]      1 [2.0]                               
      Epithelium, Hyperplasia                          3 [3.0]      7 [2.3]      2 [2.5]      4 [2.0]                               
   Stomach, Glandular                                 (48)         (50)         (50)         (50)                                   
      Cyst                                             1 [3.0]      2 [3.0]      1 [3.0]                                            
      Ulcer                                                                                   1 [3.0]                               
   Tooth                                              (2)          (4)          (1)          (3)                                    
      Malformation                                     2            4                         2                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                                                          2 [2.5]                               
      Inflammation, Chronic                            2 [2.0]      1 [3.0]      1 [1.0]      1 [3.0]                               
      Mineralization                                   1 [3.0]                                2 [2.0]                               
      Thrombosis                                                                 1 [4.0]      1 [4.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                6 [3.0]      5 [3.0]      3 [3.0]      5 [3.0]                               
      Degeneration, Fatty                              1 [1.0]      1 [2.0]                   2 [1.0]                               
      Hyperplasia, Focal                               4 [1.5]      6 [1.7]      7 [1.7]      9 [1.4]                               
      Hypertrophy                                      1 [2.0]                                                                      
      Hypertrophy, Focal                               9 [1.7]     16 [1.8]     11 [1.7]     11 [1.9]                               
      Capsule, Hyperplasia                             5 [2.0]      3 [2.0]      1 [3.0]      8 [2.4]                               
   Adrenal Medulla                                    (49)         (48)         (49)         (49)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page    9                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia                                      1 [1.0]      1 [2.0]      1 [2.0]                                            
   Islets, Pancreatic                                 (48)         (50)         (50)         (50)                                   
      Hyperplasia                                     31 [2.4]     25 [2.3]     28 [2.5]     23 [2.3]                               
   Parathyroid Gland                                  (46)         (48)         (47)         (49)                                   
      Cyst                                                          1 [3.0]      2 [3.0]      1 [3.0]                               
   Pituitary Gland                                    (47)         (47)         (45)         (49)                                   
      Pars Distalis, Cyst                              1 [3.0]      1 [3.0]      2 [3.0]      5 [3.0]                               
      Pars Intermedia, Cyst                            1 [3.0]                                                                      
   Thyroid Gland                                      (48)         (50)         (48)         (50)                                   
      Degeneration, Cystic                            13 [1.8]     17 [2.0]     14 [1.9]     15 [1.7]                               
      Follicular Cell, Hypertrophy                     2 [1.0]                   1 [1.0]      2 [1.5]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Atypia Cellular                                  1 [2.0]      6 [2.2]      4 [2.3]      3 [2.3]                               
      Granuloma Sperm                                               1 [4.0]                   1 [4.0]                               
      Inflammation, Chronic                                         1 [3.0]      1 [2.0]      1 [3.0]                               
   Preputial Gland                                    (50)         (50)         (50)         (50)                                   
      Cyst                                            22 [3.0]     26 [3.0]     15 [3.0]     29 [3.0]                               
      Inflammation, Chronic                           28 [2.4]     27 [2.4]     18 [2.2]     21 [2.2]                               
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                            1 [2.0]      4 [2.0]      3 [2.7]      5 [2.4]                               
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Degeneration                                                  1 [3.0]                   2 [3.0]                               
      Dilatation                                                                 1 [3.0]                                            
      Inflammation, Chronic                            3 [2.3]                   1 [4.0]                                            
   Testes                                             (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 [3.0]                                1 [4.0]                               
      Atrophy                                                       1 [2.0]      1 [3.0]      1 [3.0]                               
      Necrosis                                                                                1 [3.0]                               
      Germinal Epithelium, Atrophy                     1 [1.0]      5 [2.0]      3 [1.7]      4 [1.8]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)         (50)         (50)                                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   10                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                     21 [2.2]     12 [2.6]     13 [2.2]     15 [2.6]                               
   Lymph Node                                         (3)                       (1)          (3)                                    
      Mediastinal, Hemorrhage                                                                 1 [3.0]                               
   Lymph Node, Mandibular                             (49)         (48)         (45)         (49)                                   
      Atrophy                                          1 [3.0]                                1 [2.0]                               
      Hyperplasia, Lymphoid                           14 [2.4]     14 [2.3]     16 [2.2]     16 [2.3]                               
      Pigmentation                                     7 [2.0]     10 [2.2]      9 [2.1]      9 [2.1]                               
   Lymph Node, Mesenteric                             (47)         (50)         (50)         (50)                                   
      Atrophy                                          2 [2.5]      1 [2.0]                   1 [3.0]                               
      Hematopoietic Cell Proliferation                 2 [2.5]                   4 [2.5]      1 [2.0]                               
      Hemorrhage                                       4 [1.8]      6 [2.3]      2 [2.0]      4 [2.5]                               
      Hyperplasia, Lymphoid                           11 [2.7]      6 [2.8]      6 [2.8]      9 [2.6]                               
   Spleen                                             (48)         (50)         (50)         (50)                                   
      Depletion Lymphoid                                                                      1 [3.0]                               
      Hematopoietic Cell Proliferation                21 [2.8]     17 [2.6]     18 [2.8]     21 [3.3]                               
      Hyperplasia, Lymphoid                            8 [2.3]      9 [2.0]     10 [2.2]      8 [2.1]                               
      Pigmentation                                                  3 [2.0]      1 [2.0]      1 [3.0]                               
      Lymphoid Follicle, Atrophy                       1 [3.0]                   1 [2.0]      3 [3.0]                               
   Thymus                                             (43)         (43)         (40)         (44)                                   
      Atrophy                                         11 [2.6]     13 [2.6]      4 [2.5]     13 [2.5]                               
      Cyst                                             1 [3.0]      3 [3.0]      4 [3.0]      4 [3.0]                               
      Hyperplasia, Lymphoid                            2 [3.0]      1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                        1                                                                            
      Edema                                                                                   3 [3.0]                               
      Inflammation, Chronic                                                      1 [3.0]      1 [3.0]                               
      Ulcer                                            2 [3.5]                                                                      
      Epidermis, Hyperplasia                           1 [3.0]                                1 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fracture                                         1            1                         2                                     
      Hyperostosis                                     1 [3.0]      1 [3.0]                                                         
   Skeletal Muscle                                    (3)          (1)          (3)          (2)                                    
      Atrophy                                                       1 [2.0]                                                         
      Infiltration Cellular, Lipocyte                  1 [3.0]                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   11                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Peripheral Nerve                                                (1)          (2)          (1)                                    
      Atrophy                                                       1 [3.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Edema                                            6 [2.2]     11 [2.1]      7 [2.0]      8 [2.0]                               
      Foreign Body                                     1                                      1                                     
      Hemorrhage                                       5 [1.6]      3 [2.0]      4 [1.3]      5 [2.0]                               
      Hyperplasia, Lymphoid                            4 [2.0]      5 [2.0]      7 [2.0]      6 [2.0]                               
      Infiltration Cellular, Histiocyte                8 [2.6]      5 [3.0]      9 [3.1]     10 [2.5]                               
      Metaplasia, Osseous                                           2 [1.0]                                                         
      Alveolar Epithelium, Hyperplasia                 2 [1.0]      3 [1.7]      1 [1.0]      5 [1.6]                               
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1            1                         2                                     
      Inflammation, Chronic                            1 [1.0]      2 [2.5]      1 [1.0]      5 [2.8]                               
      Respiratory Epithelium, Hyperplasia              1 [1.0]      1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (50)         (50)         (50)                                   
      Cataract                                                      1 [2.0]                                                         
      Inflammation, Chronic                                                      3 [2.0]                                            
   Harderian Gland                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia, Focal                               1 [2.0]                                1 [2.0]                               
      Inflammation, Chronic                            1 [2.0]      3 [2.3]      3 [2.0]      2 [3.0]                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)         (50)                                   
      Cyst                                            14 [3.0]     10 [3.0]      9 [3.0]     10 [2.9]                               
      Hydronephrosis                                   1 [2.0]      2 [2.0]      2 [2.0]      1 [3.0]                               
      Hyperplasia, Lymphoid                            8 [2.3]      6 [2.5]      4 [2.3]     11 [2.3]                               
      Infarct                                          5 [1.8]      1 [1.0]      4 [1.3]      5 [2.2]                               
      Inflammation, Chronic                                         1 [3.0]                   1 [2.0]                               
      Metaplasia, Osseous                              7 [1.4]      5 [2.0]      3 [2.7]      4 [2.5]                               
      Nephropathy                                     37 [1.3]     42 [1.7]     43 [1.5]     36 [1.6]                               
      Renal Tubule, Accumulation, Hyaline Droplet                   1 [3.0]      1 [3.0]                                            
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                             Page   12                                                              
                                                                                                                                   
NTP Experiment-Test: 96010-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/26/03    
Route: DOSED WATER                             WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)                    Time: 10:48:04    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                             0 MG/L       500 MG/L     1000MG/L     2000MG/L                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Renal Tubule, Dilatation                         1 [2.0]      2 [2.5]                   3 [2.3]                               
      Renal Tubule, Hyperplasia                        1 [1.0]      1 [1.0]                   1 [1.0]                               
      Renal Tubule, Necrosis                           1 [2.0]                                2 [3.5]                               
      Renal Tubule, Pigmentation                                    2 [4.0]      1 [2.0]      1 [2.0]                               
   Urethra                                                                      (1)                                                 
      Angiectasis                                                                1 [4.0]                                            
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Edema                                            1 [3.0]                                1 [4.0]                               
      Hyperplasia, Lymphoid                                         1 [2.0]      1 [2.0]                                            
      Inflammation, Chronic                                                                   1 [3.0]                               
      Transitional Epithelium, Hyperplasia                          2 [2.0]                   1 [3.0]                               
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   13                                                              
                                                                                                                                   
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 96299-96299/96299


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.