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TDMS Study 05217-99 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: SOUTHERN RESEARCH INST                               T-BUTYLHYDROQUINONE                                  DATE: 04/11/95       
EXPERIMENT: 05217 TEST: 99                                                                                     TIME: 13:15:05       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-85219          ROUTE: DOSED FEED                                                                  NTP C#: C62157       
PATHOLOGIST: J. E. HEATH                                                                                       CAS: 1948-33-0       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                 05217/03 -VS- 05217/04 COMPARISON                                                  
                                                                                                                                    
               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE 001    UNTREATD CONTROL                                                              
                                       INCLUDE 002    UNTREATD CONTROL                                                              
                                       INCLUDE 005    RTD UNTRCONTROL                                                               
                                       INCLUDE 006    RTD UNTRCONTROL                                                               

 NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
 LAB: SOUTHERN RESEARCH INST                               T-BUTYLHYDROQUINONE                                  DATE: 04/11/95       
 EXPERIMENT: 05217 TEST: 99                                                                                     TIME: 13:15:05       
 TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
 CONT: N01-ES-85219          ROUTE: DOSED FEED                                                                  NTP C#: C62157       
 PATHOLOGIST: J. E. HEATH                                                                                       CAS: 1948-33-0       
 
 
                                                     RATS(FISCHER344)
                                               ----------------------------
              FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
              IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                     
                                                     ----------------
                                                     Adrenal Cortex
                                                     Adrenal Medulla
                                                     Bone Marrow
                                                     Brain
                                                     Clitoral Gland
                                                     Clitoral/Preputial Gland
                                                     Epididymis
                                                     Heart
                                                     Islets, Pancreatic
                                                     Kidney
                                                     Liver
                                                     Lung
                                                     Nose
                                                     Ovary
                                                     Pancreas
                                                     Parathyroid Gland
                                                     Pituitary Gland
                                                     Preputial Gland
                                                     Prostate
                                                     Salivary Glands
                                                     Spleen
                                                     Testes
                                                     Thymus
                                                     Thyroid Gland
                                                     Urinary Bladder

 NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
 LAB: SOUTHERN RESEARCH INST                               T-BUTYLHYDROQUINONE                                  DATE: 04/11/95       
 EXPERIMENT: 05217 TEST: 99                                                                                     TIME: 13:15:05       
 TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
 CONT: N01-ES-85219          ROUTE: DOSED FEED                                                                  NTP C#: C62157       
 PATHOLOGIST: J. E. HEATH                                                                                       CAS: 1948-33-0       
 

                                      SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                       IN THE ANALYSIS OF THE STUDY OF T-BUTYLHYDROQUINONE
               ====================================================================================================
                                                            MALE RATS
                                                           -------------
                   ORGAN                               MORPHOLOGY
                  -------                             ------------
               Clitoral/Preputial Gland      Adenoma
                                             Carcinoma or Adenoma
               Islets, Pancreatic            Carcinoma or Adenoma
               Liver                         Hepatocellular Adenoma
               Mammary Gland                 Fibroadenoma
                                             Fibroma, Fibroadenoma or Adenoma
                                             Fibroma, Fibroadenoma, Carcinoma, or Adenoma
               Pancreas                      Adenoma
               Pituitary Gland: Pars Distalis or Unspecified Site
                                             Adenoma
                                             Carcinoma or Adenoma
               Skin                          Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
                                              Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
                                             Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
                                             Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
               All Organs                    Benign Tumors
                                             Malignant and Benign Tumors
               ====================================================================================================
                                                            FEMALE RATS
                                                           -------------
                   ORGAN                               MORPHOLOGY
                  -------                             ------------
               Adrenal Cortex                Adenoma
               Clitoral/Preputial Gland      Carcinoma
                                             Carcinoma or Adenoma
               Mammary Gland                 Carcinoma
                                             Carcinoma or Adenoma
                                             Fibroadenoma
                                             Fibroma, Fibroadenoma or Adenoma
                                             Fibroma, Fibroadenoma, Carcinoma, or Adenoma
               Thyroid Gland: C-Cell         Adenoma
                                             Carcinoma or Adenoma
               All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                             Benign Tumors
                                             Malignant Tumors
                                             Malignant and Benign Tumors
               ====================================================================================================

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE   1
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Adrenal Cortex                                                                                                                   |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         1/60 (2%)           0/60 (0%)              |         4/60 (7%)           0/60 (0%)              |
 |ADJUSTED (b)           |          6.3%                0.0%                  |         25.9%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          786                 ---                   |          795                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.403N               |                             P=0.019N*              |
 |INCIDENTAL TUMOR       |                             P=0.528N               |                             P=0.044N*              |
 |LOGISTIC REGRESSION    |                             P=0.459N               |                             P=0.022N*              |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500N               |                             P=0.059N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Adrenal Medulla                                                                                                                  |
 |     Pheochromocytoma Benign                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        14/60 (23%)         12/59 (20%)             |         2/60 (3%)           4/57 (7%)              |
 |ADJUSTED (b)           |         59.8%               55.2%                  |         16.4%               17.1%                  |
 |TERMINAL (d)           |         2/8 (25%)           5/13 (38%)             |         1/10 (10%)          2/18 (11%)             |
 |FIRST INCIDENCE (DAYS) |          667                 707                   |          856                 677                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.096N               |                             P=0.592                |
 |INCIDENTAL TUMOR       |                             P=0.405N               |                             P=0.468                |
 |LOGISTIC REGRESSION    |                             P=0.210N               |                             P=0.500                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.431N               |                             P=0.315                |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE   2
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Adrenal Medulla                                                                                                                  |
 |     Pheochromocytoma Malignant                                                                                                  |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         1/60 (2%)           2/59 (3%)              |         0/60 (0%)           0/57 (0%)              |
 |ADJUSTED (b)           |          3.1%                9.7%                  |          0.0%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            1/13 (8%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          710                 661                   |          ---                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.577                |           (e)                 (e)                  |
 |INCIDENTAL TUMOR       |                             P=0.516                |           (e)                 (e)                  |
 |LOGISTIC REGRESSION    |                             P=0.513                |           (e)                 (e)                  |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.494                |                               (e)                  |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Adrenal Medulla                                                                                                                  |
 |     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        14/60 (23%)         15/59 (25%)             |         2/60 (3%)           4/57 (7%)              |
 |ADJUSTED (b)           |         59.8%               62.3%                  |         16.4%               17.1%                  |
 |TERMINAL (d)           |         2/8 (25%)           6/13 (46%)             |         1/10 (10%)          2/18 (11%)             |
 |FIRST INCIDENCE (DAYS) |          667                 552                   |          856                 677                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.242N               |                             P=0.592                |
 |INCIDENTAL TUMOR       |                             P=0.543                |                             P=0.468                |
 |LOGISTIC REGRESSION    |                             P=0.491N               |                             P=0.500                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.479                |                             P=0.315                |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE   3
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Brain                                                                                                                            |
 |     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           0/60 (0%)              |         1/60 (2%)           1/60 (2%)              |
 |ADJUSTED (b)           |          5.1%                0.0%                  |         10.0%                2.2%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          556                 ---                   |          898 (T)             730                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.211N               |                             P=0.666N               |
 |INCIDENTAL TUMOR       |                             P=0.187N               |                             P=0.693N               |
 |LOGISTIC REGRESSION    |                             P=0.296N               |                             P=0.721N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248N               |                             P=0.752N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Clitoral/Preputial Gland                                                                                                         |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         5/60 (8%)           1/60 (2%)              |         6/58 (10%)          3/59 (5%)              |
 |ADJUSTED (b)           |         31.1%                3.8%                  |         38.3%               13.4%                  |
 |TERMINAL (d)           |         2/8 (25%)           0/13 (0%)              |         3/10 (30%)          1/18 (6%)              |
 |FIRST INCIDENCE (DAYS) |          528                 786                   |          579                 866                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.050N*              |                             P=0.065N               |
 |INCIDENTAL TUMOR       |                             P=0.133N               |                             P=0.131N               |
 |LOGISTIC REGRESSION    |                             P=0.089N               |                             P=0.100N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.103N               |                             P=0.237N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE   4
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Clitoral/Preputial Gland                                                                                                         |
 |     Carcinoma                                                                                                                   |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           1/60 (2%)              |         6/58 (10%)          2/59 (3%)              |
 |ADJUSTED (b)           |          3.6%                3.8%                  |         43.2%                6.2%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         4/10 (40%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          381                 786                   |          649                 788                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.445N               |                             P=0.032N*              |
 |INCIDENTAL TUMOR       |                             P=0.633N               |                             P=0.054N               |
 |LOGISTIC REGRESSION    |                             P=0.663N               |                             P=0.053N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500N               |                             P=0.130N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Clitoral/Preputial Gland                                                                                                         |
 |     Carcinoma or Adenoma                                                                                                        |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         7/60 (12%)          2/60 (3%)              |        12/58 (21%)          5/59 (8%)              |
 |ADJUSTED (b)           |         33.6%                7.7%                  |         74.9%               18.8%                  |
 |TERMINAL (d)           |         2/8 (25%)           0/13 (0%)              |         7/10 (70%)          1/18 (6%)              |
 |FIRST INCIDENCE (DAYS) |          381                 786                   |          579                 788                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.039N*              |                             P=0.003N**             |
 |INCIDENTAL TUMOR       |                             P=0.133N               |                             P=0.011N*              |
 |LOGISTIC REGRESSION    |                             P=0.102N               |                             P=0.008N**             |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.081N               |                             P=0.053N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE   5
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Islets, Pancreatic                                                                                                               |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         5/60 (8%)           2/58 (3%)              |         2/60 (3%)           1/60 (2%)              |
 |ADJUSTED (b)           |         32.5%                8.3%                  |         11.2%                1.9%                  |
 |TERMINAL (d)           |         1/8 (13%)           0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          667                 707                   |          661                 677                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.092N               |                             P=0.388N               |
 |INCIDENTAL TUMOR       |                             P=0.249N               |                             P=0.490N               |
 |LOGISTIC REGRESSION    |                             P=0.152N               |                             P=0.535N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.234N               |                             P=0.500N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Islets, Pancreatic                                                                                                               |
 |     Carcinoma or Adenoma                                                                                                        |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         6/60 (10%)          2/58 (3%)              |         2/60 (3%)           1/60 (2%)              |
 |ADJUSTED (b)           |         42.1%                8.3%                  |         11.2%                1.9%                  |
 |TERMINAL (d)           |         2/8 (25%)           0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          667                 707                   |          661                 677                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.044N*              |                             P=0.388N               |
 |INCIDENTAL TUMOR       |                             P=0.137N               |                             P=0.490N               |
 |LOGISTIC REGRESSION    |                             P=0.075N               |                             P=0.535N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.147N               |                             P=0.500N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE   6
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Kidney: Renal Tubule                                                                                                             |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           0/60 (0%)              |         1/60 (2%)           0/60 (0%)              |
 |ADJUSTED (b)           |          5.6%                0.0%                  |         10.0%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          694                 ---                   |          898 (T)             ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.217N               |                             P=0.383N               |
 |INCIDENTAL TUMOR       |                             P=0.270N               |                             P=0.383N               |
 |LOGISTIC REGRESSION    |                             P=0.252N               |                             P=0.383N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248N               |                             P=0.500N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Liver                                                                                                                            |
 |     Hepatocellular Adenoma                                                                                                      |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         4/60 (7%)           0/60 (0%)              |         0/60 (0%)           1/60 (2%)              |
 |ADJUSTED (b)           |         25.1%                0.0%                  |          0.0%                2.0%                  |
 |TERMINAL (d)           |         1/8 (13%)           0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          642                 ---                   |          ---                 710                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.028N*              |                             P=0.546                |
 |INCIDENTAL TUMOR       |                             P=0.041N*              |                             P=0.506                |
 |LOGISTIC REGRESSION    |                             P=0.045N*              |                             P=0.451                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.059N               |                             P=0.500                |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE   7
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Lung                                                                                                                             |
 |     Alveolar/Bronchiolar Adenoma                                                                                                |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         3/60 (5%)           1/60 (2%)              |         2/60 (3%)           2/60 (3%)              |
 |ADJUSTED (b)           |         10.2%                7.7%                  |         14.5%                9.1%                  |
 |TERMINAL (d)           |         0/8 (0%)            1/13 (8%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          618                 857 (T)               |          802                 870                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.225N               |                             P=0.477N               |
 |INCIDENTAL TUMOR       |                             P=0.237N               |                             P=0.634N               |
 |LOGISTIC REGRESSION    |                             P=0.296N               |                             P=0.534N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.309N               |                             P=0.691N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Lung                                                                                                                             |
 |     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         3/60 (5%)           1/60 (2%)              |         2/60 (3%)           3/60 (5%)              |
 |ADJUSTED (b)           |         10.2%                7.7%                  |         14.5%               11.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            1/13 (8%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          618                 857 (T)               |          802                 711                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.225N               |                             P=0.642N               |
 |INCIDENTAL TUMOR       |                             P=0.237N               |                             P=0.563                |
 |LOGISTIC REGRESSION    |                             P=0.296N               |                             P=0.630                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.309N               |                             P=0.500                |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE   8
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Mammary Gland                                                                                                                    |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         1/60 (2%)           0/60 (0%)              |         3/60 (5%)           0/60 (0%)              |
 |ADJUSTED (b)           |          2.3%                0.0%                  |          9.9%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          668                 ---                   |          613                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.496N               |                             P=0.078N               |
 |INCIDENTAL TUMOR       |                             P=0.528N               |                             P=0.134N               |
 |LOGISTIC REGRESSION    |                             P=0.536N               |                             P=0.160N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500N               |                             P=0.122N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Mammary Gland                                                                                                                    |
 |     Carcinoma                                                                                                                   |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         0/60 (0%)           1/60 (2%)              |         8/60 (13%)          1/60 (2%)              |
 |ADJUSTED (b)           |          0.0%                7.7%                  |         29.3%                5.3%                  |
 |TERMINAL (d)           |         0/8 (0%)            1/13 (8%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          ---                 857 (T)               |          540                 892                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.597                |                             P=0.004N**             |
 |INCIDENTAL TUMOR       |                             P=0.597                |                             P=0.024N*              |
 |LOGISTIC REGRESSION    |                             P=0.597                |                             P=0.015N*              |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500                |                             P=0.016N*              |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE   9
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Mammary Gland                                                                                                                    |
 |     Carcinoma or Adenoma                                                                                                        |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         1/60 (2%)           1/60 (2%)              |        10/60 (17%)          1/60 (2%)              |
 |ADJUSTED (b)           |          2.3%                7.7%                  |         34.9%                5.3%                  |
 |TERMINAL (d)           |         0/8 (0%)            1/13 (8%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          668                 857 (T)               |          540                 892                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.705N               |                             P=0.001N**             |
 |INCIDENTAL TUMOR       |                             P=0.725N               |                             P=0.008N**             |
 |LOGISTIC REGRESSION    |                             P=0.739N               |                             P=0.005N**             |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.752N               |                             P=0.004N**             |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Mammary Gland                                                                                                                    |
 |     Fibroadenoma                                                                                                                |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        10/60 (17%)          4/60 (7%)              |        43/60 (72%)         30/60 (50%)             |
 |ADJUSTED (b)           |         72.0%               17.8%                  |        100.0%               86.8%                  |
 |TERMINAL (d)           |         5/8 (63%)           1/13 (8%)              |        10/10 (100%)        14/18 (78%)             |
 |FIRST INCIDENCE (DAYS) |          381                 745                   |          418                 688                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.010N**             |                             P<0.001N**             |
 |INCIDENTAL TUMOR       |                             P=0.059N               |                             P<0.001N**             |
 |LOGISTIC REGRESSION    |                             P=0.019N*              |                             P<0.001N**             |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.077N               |                             P=0.012N*              |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  10
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Mammary Gland                                                                                                                    |
 |     Fibroma, Fibroadenoma or Adenoma                                                                                            |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        11/60 (18%)          4/60 (7%)              |        45/60 (75%)         30/60 (50%)             |
 |ADJUSTED (b)           |         72.6%               17.8%                  |        100.0%               86.8%                  |
 |TERMINAL (d)           |         5/8 (63%)           1/13 (8%)              |        10/10 (100%)        14/18 (78%)             |
 |FIRST INCIDENCE (DAYS) |          381                 745                   |          418                 688                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.006N**             |                             P<0.001N**             |
 |INCIDENTAL TUMOR       |                             P=0.038N*              |                             P<0.001N**             |
 |LOGISTIC REGRESSION    |                             P=0.013N*              |                             P<0.001N**             |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.048N*              |                             P=0.004N**             |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Mammary Gland                                                                                                                    |
 |     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        11/60 (18%)          5/60 (8%)              |        48/60 (80%)         31/60 (52%)             |
 |ADJUSTED (b)           |         72.6%               24.7%                  |        100.0%               87.5%                  |
 |TERMINAL (d)           |         5/8 (63%)           2/13 (15%)             |        10/10 (100%)        14/18 (78%)             |
 |FIRST INCIDENCE (DAYS) |          381                 745                   |          418                 688                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.011N*              |                             P<0.001N**             |
 |INCIDENTAL TUMOR       |                             P=0.063N               |                             P<0.001N**             |
 |LOGISTIC REGRESSION    |                             P=0.024N*              |                             P<0.001N**             |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.089N               |                             P<0.001N**             |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  11
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
 |     Squamous Cell Carcinoma                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           1/60 (2%)              |         0/60 (0%)           0/60 (0%)              |
 |ADJUSTED (b)           |          6.9%                4.3%                  |          0.0%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          489                 796                   |          ---                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.383N               |           (e)                 (e)                  |
 |INCIDENTAL TUMOR       |                             P=0.717N               |           (e)                 (e)                  |
 |LOGISTIC REGRESSION    |                             P=0.541N               |           (e)                 (e)                  |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500N               |                               (e)                  |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
 |     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           1/60 (2%)              |         1/60 (2%)           0/60 (0%)              |
 |ADJUSTED (b)           |          6.9%                4.3%                  |         10.0%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          489                 796                   |          898 (T)             ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.383N               |                             P=0.383N               |
 |INCIDENTAL TUMOR       |                             P=0.717N               |                             P=0.383N               |
 |LOGISTIC REGRESSION    |                             P=0.541N               |                             P=0.383N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500N               |                             P=0.500N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  12
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Ovary                                                                                                                            |
 |     Granulosa Cell Tumor Benign                                                                                                 |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |                                                    |         1/60 (2%)           2/60 (3%)              |
 |ADJUSTED (b)           |                                                    |          7.7%                7.0%                  |
 |TERMINAL (d)           |                                                    |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |                                                    |          879                 837                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                                                    |                             P=0.688                |
 |INCIDENTAL TUMOR       |                                                    |                             P=0.510                |
 |LOGISTIC REGRESSION    |                                                    |                             P=0.641                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                                                    |                             P=0.500                |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Ovary                                                                                                                            |
 |     Granulosa Cell Tumor: Benign, Malignant, NOS                                                                                |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |                                                    |         1/60 (2%)           3/60 (5%)              |
 |ADJUSTED (b)           |                                                    |          7.7%                9.7%                  |
 |TERMINAL (d)           |                                                    |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |                                                    |          879                 820                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                                                    |                             P=0.529                |
 |INCIDENTAL TUMOR       |                                                    |                             P=0.315                |
 |LOGISTIC REGRESSION    |                                                    |                             P=0.438                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                                                    |                             P=0.309                |
 |=================================================================================================================================|

         DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  13
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Pancreas                                                                                                                         |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         3/60 (5%)           0/58 (0%)              |         0/60 (0%)           0/60 (0%)              |
 |ADJUSTED (b)           |         37.5%                0.0%                  |          0.0%                0.0%                  |
 |TERMINAL (d)           |         3/8 (38%)           0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          857 (T)             ---                   |          ---                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.044N*              |           (e)                 (e)                  |
 |INCIDENTAL TUMOR       |                             P=0.044N*              |           (e)                 (e)                  |
 |LOGISTIC REGRESSION    |                             P=0.044N*              |           (e)                 (e)                  |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.128N               |                               (e)                  |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Parathyroid Gland                                                                                                                |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         0/55 (0%)           0/56 (0%)              |         2/52 (4%)           0/55 (0%)              |
 |ADJUSTED (b)           |          0.0%                0.0%                  |          7.7%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/12 (0%)              |         0/8 (0%)            0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          ---                 ---                   |          785                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |           (e)                 (e)                  |                             P=0.153N               |
 |INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.209N               |
 |LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.189N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                               (e)                  |                             P=0.234N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  14
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        19/60 (32%)         13/57 (23%)             |        26/60 (43%)         30/59 (51%)             |
 |ADJUSTED (b)           |         63.8%               43.6%                  |         80.9%               81.1%                  |
 |TERMINAL (d)           |         2/8 (25%)           2/13 (15%)             |         5/10 (50%)         11/17 (65%)             |
 |FIRST INCIDENCE (DAYS) |          528                 569                   |          540                 638                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.038N*              |                             P=0.120N               |
 |INCIDENTAL TUMOR       |                             P=0.191N               |                             P=0.546                |
 |LOGISTIC REGRESSION    |                             P=0.159N               |                             P=0.484N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.193N               |                             P=0.262                |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
 |     Carcinoma                                                                                                                   |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         0/60 (0%)           0/57 (0%)              |         2/60 (3%)           0/59 (0%)              |
 |ADJUSTED (b)           |          0.0%                0.0%                  |          5.0%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         0/10 (0%)           0/17 (0%)              |
 |FIRST INCIDENCE (DAYS) |          ---                 ---                   |          540                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |           (e)                 (e)                  |                             P=0.195N               |
 |INCIDENTAL TUMOR       |           (e)                 (e)                  |                             P=0.413N               |
 |LOGISTIC REGRESSION    |           (e)                 (e)                  |                             P=0.337N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                               (e)                  |                             P=0.252N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  15
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
 |     Carcinoma or Adenoma                                                                                                        |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        19/60 (32%)         13/57 (23%)             |        28/60 (47%)         30/59 (51%)             |
 |ADJUSTED (b)           |         63.8%               43.6%                  |         81.9%               81.1%                  |
 |TERMINAL (d)           |         2/8 (25%)           2/13 (15%)             |         5/10 (50%)         11/17 (65%)             |
 |FIRST INCIDENCE (DAYS) |          528                 569                   |          540                 638                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.038N*              |                             P=0.070N               |
 |INCIDENTAL TUMOR       |                             P=0.191N               |                             P=0.510N               |
 |LOGISTIC REGRESSION    |                             P=0.159N               |                             P=0.364N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.193N               |                             P=0.393                |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Prostate                                                                                                                         |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           0/60 (0%)              |                                                    |
 |ADJUSTED (b)           |         25.0%                0.0%                  |                                                    |
 |TERMINAL (d)           |         2/8 (25%)           0/13 (0%)              |                                                    |
 |FIRST INCIDENCE (DAYS) |          857 (T)             ---                   |                                                    |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.135N               |                                                    |
 |INCIDENTAL TUMOR       |                             P=0.135N               |                                                    |
 |LOGISTIC REGRESSION    |                             P=0.135N               |                                                    |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248N               |                                                    |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  16
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Skin                                                                                                                             |
 |     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
 |     malignant or NOS), or Trichoepithelioma                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         3/60 (5%)           1/60 (2%)              |         1/60 (2%)           2/60 (3%)              |
 |ADJUSTED (b)           |         16.5%                7.7%                  |          2.2%                7.5%                  |
 |TERMINAL (d)           |         0/8 (0%)            1/13 (8%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          759                 857 (T)               |          640                 777                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.168N               |                             P=0.639                |
 |INCIDENTAL TUMOR       |                             P=0.300N               |                             P=0.489                |
 |LOGISTIC REGRESSION    |                             P=0.223N               |                             P=0.507                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.309N               |                             P=0.500                |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Skin                                                                                                                             |
 |     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
 |     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         8/60 (13%)          2/60 (3%)              |         1/60 (2%)           2/60 (3%)              |
 |ADJUSTED (b)           |         50.3%               15.4%                  |          2.2%                7.5%                  |
 |TERMINAL (d)           |         3/8 (38%)           2/13 (15%)             |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          667                 857 (T)               |          640                 777                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.009N**             |                             P=0.639                |
 |INCIDENTAL TUMOR       |                             P=0.022N*              |                             P=0.489                |
 |LOGISTIC REGRESSION    |                             P=0.016N*              |                             P=0.507                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.047N*              |                             P=0.500                |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  17
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Skin                                                                                                                             |
 |     Fibroma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         4/60 (7%)           6/60 (10%)             |         3/60 (5%)           1/60 (2%)              |
 |ADJUSTED (b)           |         30.0%               32.3%                  |         13.8%                3.7%                  |
 |TERMINAL (d)           |         1/8 (13%)           3/13 (23%)             |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          761                 730                   |          540                 856                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.588N               |                             P=0.186N               |
 |INCIDENTAL TUMOR       |                             P=0.437                |                             P=0.378N               |
 |LOGISTIC REGRESSION    |                             P=0.594                |                             P=0.326N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.372                |                             P=0.309N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Skin                                                                                                                             |
 |     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         5/60 (8%)           6/60 (10%)             |         4/60 (7%)           1/60 (2%)              |
 |ADJUSTED (b)           |         40.0%               32.3%                  |         19.9%                3.7%                  |
 |TERMINAL (d)           |         2/8 (25%)           3/13 (23%)             |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          761                 730                   |          540                 856                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.425N               |                             P=0.078N               |
 |INCIDENTAL TUMOR       |                             P=0.599                |                             P=0.222N               |
 |LOGISTIC REGRESSION    |                             P=0.507N               |                             P=0.167N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500                |                             P=0.182N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  18
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Skin                                                                                                                             |
 |     Keratoacanthoma                                                                                                             |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         4/60 (7%)           1/60 (2%)              |         0/60 (0%)           0/60 (0%)              |
 |ADJUSTED (b)           |         28.6%                7.7%                  |          0.0%                0.0%                  |
 |TERMINAL (d)           |         2/8 (25%)           1/13 (8%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          667                 857 (T)               |          ---                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.096N               |           (e)                 (e)                  |
 |INCIDENTAL TUMOR       |                             P=0.113N               |           (e)                 (e)                  |
 |LOGISTIC REGRESSION    |                             P=0.122N               |           (e)                 (e)                  |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.182N               |                               (e)                  |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Skin                                                                                                                             |
 |     Squamous Cell Papilloma                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           0/60 (0%)              |         0/60 (0%)           0/60 (0%)              |
 |ADJUSTED (b)           |         19.2%                0.0%                  |          0.0%                0.0%                  |
 |TERMINAL (d)           |         1/8 (13%)           0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          795                 ---                   |          ---                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.134N               |           (e)                 (e)                  |
 |INCIDENTAL TUMOR       |                             P=0.201N               |           (e)                 (e)                  |
 |LOGISTIC REGRESSION    |                             P=0.149N               |           (e)                 (e)                  |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248N               |                               (e)                  |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  19
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Skin                                                                                                                             |
 |     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         6/60 (10%)          1/60 (2%)              |         0/60 (0%)           0/60 (0%)              |
 |ADJUSTED (b)           |         45.1%                7.7%                  |          0.0%                0.0%                  |
 |TERMINAL (d)           |         3/8 (38%)           1/13 (8%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          667                 857 (T)               |          ---                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.016N*              |           (e)                 (e)                  |
 |INCIDENTAL TUMOR       |                             P=0.028N*              |           (e)                 (e)                  |
 |LOGISTIC REGRESSION    |                             P=0.025N*              |           (e)                 (e)                  |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.057N               |                               (e)                  |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Skin                                                                                                                             |
 |     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         6/60 (10%)          1/60 (2%)              |         0/60 (0%)           0/60 (0%)              |
 |ADJUSTED (b)           |         45.1%                7.7%                  |          0.0%                0.0%                  |
 |TERMINAL (d)           |         3/8 (38%)           1/13 (8%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          667                 857 (T)               |          ---                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.016N*              |           (e)                 (e)                  |
 |INCIDENTAL TUMOR       |                             P=0.028N*              |           (e)                 (e)                  |
 |LOGISTIC REGRESSION    |                             P=0.025N*              |           (e)                 (e)                  |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.057N               |                               (e)                  |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  20
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Skin                                                                                                                             |
 |     Trichoepithelioma                                                                                                           |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           0/60 (0%)              |         0/60 (0%)           1/60 (2%)              |
 |ADJUSTED (b)           |         12.1%                0.0%                  |          0.0%                2.4%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          759                 ---                   |          ---                 777                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.145N               |                             P=0.581                |
 |INCIDENTAL TUMOR       |                             P=0.270N               |                             P=0.506                |
 |LOGISTIC REGRESSION    |                             P=0.199N               |                             P=0.511                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248N               |                             P=0.500                |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Spleen                                                                                                                           |
 |     Fibroma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           0/60 (0%)              |         0/60 (0%)           0/60 (0%)              |
 |ADJUSTED (b)           |         19.2%                0.0%                  |          0.0%                0.0%                  |
 |TERMINAL (d)           |         1/8 (13%)           0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          795                 ---                   |          ---                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.134N               |           (e)                 (e)                  |
 |INCIDENTAL TUMOR       |                             P=0.201N               |           (e)                 (e)                  |
 |LOGISTIC REGRESSION    |                             P=0.149N               |           (e)                 (e)                  |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248N               |                               (e)                  |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  21
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Testes                                                                                                                           |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        55/60 (92%)         59/60 (98%)             |                                                    |
 |ADJUSTED (b)           |        100.0%              100.0%                  |                                                    |
 |TERMINAL (d)           |         8/8 (100%)         13/13 (100%)            |                                                    |
 |FIRST INCIDENCE (DAYS) |          489                 484                   |                                                    |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.113N               |                                                    |
 |INCIDENTAL TUMOR       |                             P=0.228                |                                                    |
 |LOGISTIC REGRESSION    |                             P=0.185                |                                                    |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.103                |                                                    |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Thyroid Gland: C-Cell                                                                                                            |
 |     Adenoma                                                                                                                     |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         5/60 (8%)           7/60 (12%)             |         7/60 (12%)          3/60 (5%)              |
 |ADJUSTED (b)           |         25.2%               28.3%                  |         44.9%               11.4%                  |
 |TERMINAL (d)           |         0/8 (0%)            2/13 (15%)             |         4/10 (40%)          1/18 (6%)              |
 |FIRST INCIDENCE (DAYS) |          730                 604                   |          540                 677                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.598N               |                             P=0.040N*              |
 |INCIDENTAL TUMOR       |                             P=0.486                |                             P=0.096N               |
 |LOGISTIC REGRESSION    |                             P=0.442                |                             P=0.090N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.381                |                             P=0.161N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  22
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Thyroid Gland: C-Cell                                                                                                            |
 |     Carcinoma or Adenoma                                                                                                        |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         5/60 (8%)           7/60 (12%)             |         8/60 (13%)          3/60 (5%)              |
 |ADJUSTED (b)           |         25.2%               28.3%                  |         54.1%               11.4%                  |
 |TERMINAL (d)           |         0/8 (0%)            2/13 (15%)             |         5/10 (50%)          1/18 (6%)              |
 |FIRST INCIDENCE (DAYS) |          730                 604                   |          540                 677                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.598N               |                             P=0.017N*              |
 |INCIDENTAL TUMOR       |                             P=0.486                |                             P=0.045N*              |
 |LOGISTIC REGRESSION    |                             P=0.442                |                             P=0.044N*              |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.381                |                             P=0.102N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Thyroid Gland: Follicular Cell                                                                                                   |
 |     Carcinoma                                                                                                                   |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |                                                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         0/60 (0%)           2/60 (3%)              |         1/60 (2%)           0/60 (0%)              |
 |ADJUSTED (b)           |          0.0%               10.3%                  |         10.0%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            1/13 (8%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          ---                 732                   |          898 (T)             ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.320                |                             P=0.383N               |
 |INCIDENTAL TUMOR       |                             P=0.275                |                             P=0.383N               |
 |LOGISTIC REGRESSION    |                             P=0.289                |                             P=0.383N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248                |                             P=0.500N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  23
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Uterus                                                                                                                           |
 |     Polyp Stromal                                                                                                               |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |                                                    |         7/60 (12%)          8/60 (13%)             |
 |ADJUSTED (b)           |                                                    |         28.7%               21.2%                  |
 |TERMINAL (d)           |                                                    |         1/10 (10%)          1/18 (6%)              |
 |FIRST INCIDENCE (DAYS) |                                                    |          649                 562                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                                                    |                             P=0.428N               |
 |INCIDENTAL TUMOR       |                                                    |                             P=0.574                |
 |LOGISTIC REGRESSION    |                                                    |                             P=0.513                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                                                    |                             P=0.500                |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Uterus                                                                                                                           |
 |     Sarcoma Stromal                                                                                                             |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |                                                    |         2/60 (3%)           0/60 (0%)              |
 |ADJUSTED (b)           |                                                    |          8.7%                0.0%                  |
 |TERMINAL (d)           |                                                    |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |                                                    |          302                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                                                    |                             P=0.168N               |
 |INCIDENTAL TUMOR       |                                                    |                             P=0.494N               |
 |LOGISTIC REGRESSION    |                                                    |                             P=0.427N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                                                    |                             P=0.248N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  24
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Uterus                                                                                                                           |
 |     Sarcoma Stromal or Polyp Stromal                                                                                            |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |                                                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |                                                    |         9/60 (15%)          8/60 (13%)             |
 |ADJUSTED (b)           |                                                    |         34.9%               21.2%                  |
 |TERMINAL (d)           |                                                    |         1/10 (10%)          1/18 (6%)              |
 |FIRST INCIDENCE (DAYS) |                                                    |          302                 562                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                                                    |                             P=0.227N               |
 |INCIDENTAL TUMOR       |                                                    |                             P=0.534N               |
 |LOGISTIC REGRESSION    |                                                    |                             P=0.572N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                                                    |                             P=0.500N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |Zymbal's Gland                                                                                                                   |
 |     Carcinoma                                                                                                                   |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           0/60 (0%)              |         0/60 (0%)           1/60 (2%)              |
 |ADJUSTED (b)           |          9.9%                0.0%                  |          0.0%                2.7%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          500                 ---                   |          ---                 808                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.176N               |                             P=0.633                |
 |INCIDENTAL TUMOR       |                             P=0.440N               |                             P=0.506                |
 |LOGISTIC REGRESSION    |                             P=0.283N               |                             P=0.537                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248N               |                             P=0.500                |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  25
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |All Organs                                                                                                                       |
 |     Hemangiosarcoma or Hemangioma                                                                                               |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           0/60 (0%)              |         1/60 (2%)           0/60 (0%)              |
 |ADJUSTED (b)           |         14.3%                0.0%                  |         10.0%                0.0%                  |
 |TERMINAL (d)           |         1/8 (13%)           0/13 (0%)              |         1/10 (10%)          0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          626                 ---                   |          898 (T)             ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.181N               |                             P=0.383N               |
 |INCIDENTAL TUMOR       |                             P=0.129N               |                             P=0.383N               |
 |LOGISTIC REGRESSION    |                             P=0.225N               |                             P=0.383N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248N               |                             P=0.500N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |All Organs                                                                                                                       |
 |     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        39/60 (65%)         46/60 (77%)             |        27/60 (45%)         37/60 (62%)             |
 |ADJUSTED (b)           |         87.2%               86.9%                  |         76.5%               74.3%                  |
 |TERMINAL (d)           |         4/8 (50%)           7/13 (54%)             |         5/10 (50%)          8/18 (44%)             |
 |FIRST INCIDENCE (DAYS) |          534                 484                   |          421                 504                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.331N               |                             P=0.428N               |
 |INCIDENTAL TUMOR       |                             P=0.103                |                             P=0.058                |
 |LOGISTIC REGRESSION    |                             P=0.099                |                             P=0.036 *              |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.114                |                             P=0.050 *              |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  26
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |All Organs                                                                                                                       |
 |     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         2/60 (3%)           0/60 (0%)              |         0/60 (0%)           0/60 (0%)              |
 |ADJUSTED (b)           |         12.8%                0.0%                  |          0.0%                0.0%                  |
 |TERMINAL (d)           |         0/8 (0%)            0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          563                 ---                   |          ---                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.162N               |           (e)                 (e)                  |
 |INCIDENTAL TUMOR       |                             P=0.187N               |           (e)                 (e)                  |
 |LOGISTIC REGRESSION    |                             P=0.253N               |           (e)                 (e)                  |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.248N               |                               (e)                  |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |All Organs                                                                                                                       |
 |     Mesothelioma: Benign, Malignant, NOS                                                                                        |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |         1/60 (2%)           3/60 (5%)              |         1/60 (2%)           0/60 (0%)              |
 |ADJUSTED (b)           |         12.5%                6.0%                  |          1.7%                0.0%                  |
 |TERMINAL (d)           |         1/8 (13%)           0/13 (0%)              |         0/10 (0%)           0/18 (0%)              |
 |FIRST INCIDENCE (DAYS) |          857 (T)             552                   |          380                 ---                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.379                |                             P=0.493N               |
 |INCIDENTAL TUMOR       |                             P=0.452                |                             P=0.872N               |
 |LOGISTIC REGRESSION    |                             P=0.258                |                             P=0.975N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.309                |                             P=0.500N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  27
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |All Organs                                                                                                                       |
 |     Benign Tumors                                                                                                               |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        60/60 (100%)        59/60 (98%)             |        52/60 (87%)         46/60 (77%)             |
 |ADJUSTED (b)           |        100.0%              100.0%                  |        100.0%               95.6%                  |
 |TERMINAL (d)           |         8/8 (100%)         13/13 (100%)            |        10/10 (100%)        16/18 (89%)             |
 |FIRST INCIDENCE (DAYS) |          381                 484                   |          418                 562                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.042N*              |                             P<0.001N**             |
 |INCIDENTAL TUMOR       |                             P=0.472N               |                             P=0.002N**             |
 |LOGISTIC REGRESSION    |                             P=0.493N               |                             P=0.001N**             |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500N               |                             P=0.119N               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |All Organs                                                                                                                       |
 |     Malignant Tumors                                                                                                            |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        51/60 (85%)         52/60 (87%)             |        41/60 (68%)         40/60 (67%)             |
 |ADJUSTED (b)           |         95.5%               94.0%                  |        100.0%               76.7%                  |
 |TERMINAL (d)           |         6/8 (75%)          10/13 (77%)             |        10/10 (100%)         8/18 (44%)             |
 |FIRST INCIDENCE (DAYS) |          381                 484                   |          302                 504                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.098N               |                             P=0.029N*              |
 |INCIDENTAL TUMOR       |                             P=0.570                |                             P=0.569                |
 |LOGISTIC REGRESSION    |                             P=0.440                |                             P=0.545                |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500                |                             P=0.500N               |
 |=================================================================================================================================|

          DATE: 04/11/95                     EXPERIMENT: 05217 TEST: 99                                                 PAGE  28
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
                                                  MALE TERMINAL SACRIFICE AT 123 WEEKS
                                                  FEMALE TERMINAL SACRIFICE AT 129 WEEKS
 |=================================================================================================================================|
 |                       |                                                    |                                                    |
 |                       |                       MALES                        |                      FEMALES                       |
 |                       |                                                    |                                                    |
 |DOSE                   |          UNTREATD            RTD UNTR              |          UNTREATD            RTD UNTR              |
 |                       |          CONTROL             CONTROL               |          CONTROL             CONTROL               |
 |=================================================================================================================================|
 |                                                                                                                                 |
 |All Organs                                                                                                                       |
 |     Malignant and Benign Tumors                                                                                                 |
 |                                                                                                                                 |
 |---------------------------------------------------------------------------------------------------------------------------------|
 |TUMOR RATES            |           #                   #                    |           #                   #                    |
 |-----------            |                                                    |                                                    |
 |OVERALL (a)            |        60/60 (100%)        59/60 (98%)             |        59/60 (98%)         59/60 (98%)             |
 |ADJUSTED (b)           |        100.0%              100.0%                  |        100.0%               98.3%                  |
 |TERMINAL (d)           |         8/8 (100%)         13/13 (100%)            |        10/10 (100%)        17/18 (94%)             |
 |FIRST INCIDENCE (DAYS) |          381                 484                   |          302                 504                   |
 |-----------------------|                                                    |                                                    |
 |STATISTICAL TESTS (f)  |                                                    |                                                    |
 |-----------------------|                                                    |                                                    |
 |LIFE TABLE             |                             P=0.042N*              |                             P=0.008N**             |
 |INCIDENTAL TUMOR       |                             P=0.472N               |                             P=0.617N               |
 |LOGISTIC REGRESSION    |                             P=0.493N               |                             P=0.599N               |
 |COCHRAN-ARMITAGE       |                                                    |                                                    |
 |FISHER EXACT           |                             P=0.500N               |                             P=0.752N               |
 |=================================================================================================================================|
0 (a)  Number of tumor-bearing animals / number of animals examined at site.
  (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
       intercurrent mortality.
  (d)  Observed incidence at terminal kill.
  (f)  Beneath the control incidence are the P-values associated with the trend 
       test.  Beneath the dosed group incidence are the P-values corresponding to 
       pairwise comparisons between the controls and that dosed group.  The life
       table analysis regards tumors in animals dying  prior to terminal kill as
       being (directly or indirectly) the cause of death.  The incidental tumor 
       test regards these lesions as non-fatal.  Logistic regression is an alternative
       method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
       and Fisher's exact tests compare directly the overall incidence rates.  
       For all tests, a negative trend is indicated by "N".
  (e)  Value of Statistic cannot be computed. 
  (I)  Interim sacrifice
  (T)  Terminal sacrifice
   #   Tumor rates based on number of animals necropsied.
0  *   To the right of any statistical result, indicates significance at (P<=0.05).
   **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.