National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/16731

TDMS Study 05135-06 Pathology Tables

NTP Experiment-Test: 05135-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:50




       Facility:  Battelle Northwest

       Chemical CAS #:  78-79-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05135-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially In Study                          40           40           40           40           40           40           
                                                                                                                                    
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 1            1            1            1            1            5           
    Natural Death                                      1            1            1            2            3            4           
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           28           28           27           26           21           
                                                                                                                                    
  Animals Examined Microscopically                    40           40           40           40           40           40           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (39)         (10)         (10)         (12)         (37)         (33)         
      Inflammation, Suppurative                                                               1 (8%)       1 (3%)                   
   Intestine Large, Cecum                             (40)         (12)         (11)         (14)         (37)         (37)         
      Parasite                                                                                1 (7%)                                
   Intestine Small, Duodenum                          (39)         (12)         (10)         (12)         (37)         (36)         
      Serosa, Inflammation, Chronic                                                                        1 (3%)                   
   Intestine Small, Jejunum                           (40)         (11)         (11)         (13)         (38)         (36)         
      Parasite                                                                                                          1 (3%)      
   Intestine Small, Ileum                             (40)         (11)         (11)         (13)         (37)         (36)         
      Parasite                                                                                                          1 (3%)      
   Liver                                              (40)         (40)         (39)         (40)         (40)         (38)         
      Angiectasis                                                                             2 (5%)       1 (3%)       2 (5%)      
      Basophilic Focus                                 3 (8%)       1 (3%)       2 (5%)       4 (10%)      5 (13%)      4 (11%)     
      Clear Cell Focus                                                                        2 (5%)                    1 (3%)      
      Deformity                                        1 (3%)                                                                       
      Eosinophilic Focus                               1 (3%)                                 6 (15%)      5 (13%)      3 (8%)      
      Hematopoietic Cell Proliferation                                                                     2 (5%)       1 (3%)      
      Hyperplasia, Focal                                                                                   1 (3%)                   
      Infarct                                                       1 (3%)                                                          
      Inflammation, Chronic                                                                                1 (3%)                   
      Mixed Cell Focus                                                           1 (3%)       1 (3%)       2 (5%)       3 (8%)      
      Necrosis                                                                   1 (3%)       1 (3%)                    2 (5%)      
      Vacuolization Cytoplasmic                       22 (55%)     25 (63%)     27 (69%)     20 (50%)     24 (60%)     14 (37%)     
      Bile Duct, Hyperplasia                                                                                            1 (3%)      
   Mesentery                                          (1)          (2)                       (2)          (4)          (2)          
      Angiectasis                                                                             1 (50%)                               
      Necrosis                                         1 (100%)     2 (100%)                  2 (100%)     2 (50%)      2 (100%)    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    2                                                              
                                                                                                                                   
NTP Experiment-Test: 05135-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (40)         (40)         (39)         (40)         (40)         (38)         
      Angiectasis                                                                                                       1 (3%)      
      Focal Cellular Change                            2 (5%)       1 (3%)                    5 (13%)      3 (8%)       6 (16%)     
      Inflammation, Chronic                                         2 (5%)                                 1 (3%)       1 (3%)      
      Duct, Cyst                                                    1 (3%)                                              1 (3%)      
   Salivary Glands                                    (40)         (12)         (11)         (13)         (40)         (38)         
      Inflammation, Suppurative                        2 (5%)                                                                       
   Stomach, Forestomach                               (40)         (40)         (39)         (40)         (40)         (38)         
      Angiectasis                                                                                          2 (5%)                   
      Infiltration Cellular, Mast Cell                                           1 (3%)                                             
      Epithelium, Hyperplasia                          1 (3%)       2 (5%)                   16 (40%)     19 (48%)     15 (39%)     
   Stomach, Glandular                                 (40)         (40)         (39)         (40)         (38)         (37)         
      Hyperplasia                                                   1 (3%)                    3 (8%)       2 (5%)       4 (11%)     
      Inflammation, Suppurative                                     1 (3%)                    1 (3%)                    2 (5%)      
      Necrosis                                                                                                          2 (5%)      
      Pigmentation, Hemosiderin                                     1 (3%)                    1 (3%)                                
      Ulcer                                            1 (3%)                                 1 (3%)                                
   Tooth                                              (1)                       (2)                                                 
      Deformity                                                                  1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (40)         (12)         (11)         (13)         (40)         (38)         
      Pericardium, Hemorrhage                          1 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (40)         (12)         (11)         (13)         (39)         (38)         
      Hematopoietic Cell Proliferation                                                                     1 (3%)                   
      Hemorrhage                                       1 (3%)                                                                       
      Hyperplasia                                      6 (15%)                                             8 (21%)      6 (16%)     
      Hyperplasia, Focal                                                                                                1 (3%)      
      Hypertrophy, Focal                               5 (13%)                                             6 (15%)      4 (11%)     
   Islets, Pancreatic                                 (40)         (40)         (39)         (40)         (40)         (38)         
      Angiectasis                                                                                                       1 (3%)      
      Hyperplasia                                      9 (23%)      9 (23%)     12 (31%)     12 (30%)     16 (40%)     13 (34%)     
   Pituitary Gland                                    (38)         (12)         (10)         (13)         (37)         (35)         
      Pars Distalis, Cyst                              2 (5%)                    1 (10%)                                            
      Pars Intermedia, Hyperplasia                     1 (3%)                                                                       
   Thyroid Gland                                      (40)         (12)         (11)         (13)         (39)         (38)         
      Cyst                                             1 (3%)                                              1 (3%)       1 (3%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    3                                                              
                                                                                                                                   
NTP Experiment-Test: 05135-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicular Cell, Hyperplasia                                                                         1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (40)         (12)         (11)         (13)         (40)         (39)         
      Hyperplasia                                                                                                       1 (3%)      
      Inflammation                                                  1 (8%)                                              1 (3%)      
   Preputial Gland                                    (40)         (13)         (11)         (16)         (39)         (37)         
      Angiectasis                                                                             1 (6%)                    1 (3%)      
      Atrophy                                                                                              1 (3%)       1 (3%)      
      Hemorrhage                                                    1 (8%)                                                          
      Inflammation, Chronic                                                                   1 (6%)                    1 (3%)      
      Inflammation, Suppurative                        1 (3%)       3 (23%)                                1 (3%)                   
      Necrosis                                                      1 (8%)                                                          
   Prostate                                           (38)         (12)         (11)         (13)         (39)         (37)         
      Hyperplasia                                                                                          2 (5%)                   
      Inflammation, Suppurative                                                               2 (15%)                               
   Seminal Vesicle                                    (40)         (12)         (11)         (13)         (40)         (38)         
      Inflammation, Suppurative                                                               1 (8%)                                
   Testes                                             (40)         (40)         (39)         (40)         (40)         (39)         
      Atrophy                                                                    1 (3%)                                 8 (21%)     
      Mineralization                                                                                                    1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (40)         (12)         (11)         (13)         (40)         (38)         
      Angiectasis                                                                                          1 (3%)                   
      Hyperplasia                                      1 (3%)                                 1 (8%)       2 (5%)       4 (11%)     
   Lymph Node                                         (1)          (1)                                                              
      Iliac, Hyperplasia                               1 (100%)     1 (100%)                                                        
      Inguinal, Hyperplasia                            1 (100%)                                                                     
   Lymph Node, Mesenteric                             (40)         (13)         (9)          (13)         (39)         (37)         
      Hyperplasia                                                   1 (8%)                    1 (8%)       1 (3%)                   
      Necrosis                                                      1 (8%)                                                          
   Lymph Node, Mediastinal                            (19)         (10)         (7)          (9)          (20)         (22)         
      Hyperplasia                                                                                          1 (5%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    4                                                              
                                                                                                                                   
NTP Experiment-Test: 05135-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (40)         (15)         (11)         (13)         (40)         (38)         
      Accessory Spleen                                              1 (7%)                                                          
      Hematopoietic Cell Proliferation                 2 (5%)       1 (7%)                                 2 (5%)       4 (11%)     
      Infiltration Cellular, Histiocyte                                                       1 (8%)                                
      Necrosis                                                      1 (7%)                                                          
      Pigmentation, Melanin                            1 (3%)       3 (20%)                   1 (8%)       1 (3%)                   
   Thymus                                             (40)         (12)         (11)         (13)         (39)         (36)         
      Atrophy                                                                                 1 (8%)       1 (3%)                   
      Necrosis                                                      2 (17%)                                             1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (40)         (14)         (11)         (14)         (40)         (39)         
      Cyst Epithelial Inclusion                                                                            1 (3%)                   
      Hemorrhage                                                    1 (7%)                                 1 (3%)                   
      Inflammation, Suppurative                                     2 (14%)                                             1 (3%)      
      Prepuce, Inflammation, Chronic                   2 (5%)       1 (7%)                    1 (7%)       2 (5%)       2 (5%)      
      Sebaceous Gland, Hyperplasia                                                                                      1 (3%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (40)         (12)         (12)         (13)         (40)         (39)         
      Osteopetrosis                                                              1 (8%)                                             
   Skeletal Muscle                                    (40)         (40)         (39)         (40)         (40)         (38)         
      Atrophy                                                                                                           4 (11%)     
      Inflammation                                                               1 (3%)                    1 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (40)         (12)         (11)         (13)         (40)         (38)         
      Cyst Epithelial Inclusion                                                  1 (9%)                                             
      Hemorrhage                                                                              2 (15%)                               
      Mineralization                                   1 (3%)                                              2 (5%)                   
      Necrosis                                                                                1 (8%)                                
   Peripheral Nerve                                   (40)         (40)         (39)         (39)         (38)         (38)         
      Sciatic, Degeneration                                                                   1 (3%)       1 (3%)       5 (13%)     
   Spinal Cord                                        (40)         (40)         (39)         (40)         (39)         (38)         
      Degeneration                                     4 (10%)     20 (50%)     19 (49%)     28 (70%)     18 (46%)     23 (61%)     
      Meninges, Cyst Epithelial Inclusion                                        1 (3%)                                 1 (3%)      
      Meninges, Hemorrhage                             1 (3%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    5                                                              
                                                                                                                                   
NTP Experiment-Test: 05135-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (40)         (12)         (11)         (13)         (38)         (38)         
      Inflammation                                                                                                      1 (3%)      
   Lung                                               (40)         (40)         (39)         (40)         (40)         (38)         
      Congestion                                       3 (8%)                                                           2 (5%)      
      Hemorrhage                                       3 (8%)       2 (5%)       2 (5%)       1 (3%)       2 (5%)       2 (5%)      
      Metaplasia, Osseous                              1 (3%)                                                                       
      Thrombosis                                                                              1 (3%)                    1 (3%)      
      Alveolar Epithelium, Hyperplasia                 1 (3%)       1 (3%)                    3 (8%)       5 (13%)      7 (18%)     
   Nose                                               (40)         (40)         (39)         (40)         (40)         (38)         
      Inflammation                                                                                                      2 (5%)      
      Turbinate, Inflammation                                                    1 (3%)       1 (3%)                                
      Turbinate, Inflammation, Suppurative                                                                              1 (3%)      
      Turbinate, Olfactory Epithelium, Degeneration    1 (3%)       2 (5%)       5 (13%)     12 (30%)     26 (65%)     38 (100%)    
      Turbinate, Olfactory Epithelium,                                                                                              
        Inflammation, Chronic                                                                              1 (3%)      30 (79%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (40)         (12)         (12)         (13)         (40)         (40)         
      Inflammation, Chronic                                                                                             1 (3%)      
   Harderian Gland                                    (40)         (40)         (39)         (40)         (40)         (38)         
      Hyperplasia                                      1 (3%)                    3 (8%)       2 (5%)       3 (8%)       2 (5%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (40)         (13)         (11)         (14)         (40)         (38)         
      Bilateral, Fibrosis                              2 (5%)                                                           1 (3%)      
      Bilateral, Fibrosis, Focal                                                                                        1 (3%)      
      Bilateral, Hydronephrosis                        2 (5%)       1 (8%)                    1 (7%)       1 (3%)       1 (3%)      
      Bilateral, Metaplasia, Osseous                   1 (3%)                                              1 (3%)                   
      Bilateral, Nephropathy                                                                                            1 (3%)      
      Bilateral, Cortex, Pelvis, Inflammation,                                                                                      
         Suppurative                                                                          1 (7%)                                
      Bilateral, Pelvis, Inflammation, Suppurative     1 (3%)       1 (8%)                    1 (7%)                                
      Bilateral, Renal Tubule, Hyperplasia             1 (3%)                                              2 (5%)                   
   Urinary Bladder                                    (40)         (15)         (11)         (13)         (40)         (38)         
      Calculus Micro Observation Only                  1 (3%)       1 (7%)                                                          
      Dilatation                                       1 (3%)       2 (13%)                   1 (8%)                                
      Inflammation, Suppurative                        2 (5%)                                                           1 (3%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                             Page    6                                                              
                                                                                                                                   
NTP Experiment-Test: 05135-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SIX MONTH EXPOS.                                     ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:50    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia             1 (3%)                                 1 (8%)                                
                                                                                                                                    
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page    7                                                              
                                                                                                                                   
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                             ----------              END OF REPORT             ----------                                           
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