National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/13355

Target Organs and Levels of Evidence for TR-009

Bioassay of Heptachlor for Possible Carcinogenicity (CASRN 76-44-8)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Heptachlor
76-44-8
NASubterranean termite control. Dipping of roots or tops of non-food plants for insect control (NTP executive summary). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
MR: 0,38.9,77.9 (AVG), FR: 0,25.7,51.3 (AVG), MM: 0,6.1,13.8 (AVG), FM: 0,9,18 (AVG) PPM/50 PER GROUP
Gulf South Research Institute

Levels of Evidence

Male Rats: Negative
Female Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Thyroid Gland Follicular Cell: ADENOMA OR CARCINOMA
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (CARCINOMA)


NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.