National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/14760

Target Organs and Levels of Evidence for TR-054

Bioassay of 2,4-Dinitrotoluene for Possible Carcinogenicity (CASRN 121-14-2)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2,4-Dinitrotoluene
121-14-2
01/18/1978Dye intermediate; explosivesDosed-Feed
R: 0,.008,.02 (AVG), M: 0,.008,.04 (AVG) %/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Skin: (FIBROMA)
Female Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Mammary Gland: (FIBROADENOMA)
Male Mice: Negative
Female Mice: Negative


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