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https://ntp.niehs.nih.gov/go/8244

Target Organs and Levels of Evidence for TR-082

Bioassay of N-Phenyl-p-phenylenediamine for Possible Carcinogenicity (CASRN 101-54-2)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
N-Phenyl-p-phenylenediamine
101-54-2
03/06/1978Industrial intermediate, hair dyes. Used in the production of several different chemical products. It is an intermediate for photographic chemicals, pharmaceuticals, microbicides, and other organics; it is used in the manufacture of dyes and dye reagents; and it reacts with ketones to form derivatives of p-phenylenediamine which are used as antiozonants in rubber. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,600,1200, MM: 0,2057,4114 (AVG), FM: 0,3672,8170 (AVG) PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative