Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Target Organs and Levels of Evidence for TR-082

Bioassay of N-Phenyl-p-phenylenediamine for Possible Carcinogenicity (CASRN 101-54-2)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
03/06/1978Industrial intermediate, hair dyes. Used in the production of several different chemical products. It is an intermediate for photographic chemicals, pharmaceuticals, microbicides, and other organics; it is used in the manufacture of dyes and dye reagents; and it reacts with ketones to form derivatives of p-phenylenediamine which are used as antiozonants in rubber. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,600,1200, MM: 0,2057,4114 (AVG), FM: 0,3672,8170 (AVG) PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative