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https://ntp.niehs.nih.gov/go/6223

Target Organs and Levels of Evidence for TR-165

Bioassay of 4-Chloro-o-toluidine Hydrochloride for Possible Carcinogenicity (CASRN 3165-93-3)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
4-Chloro-o-toluidine hydrochloride
3165-93-3
12/13/1978Dye intermediateDosed-Feed
R&FM: 0,1250,5000, MM: 0,3750,15000 PPM/50 PER GROUP
Frederick Cancer Research Facility

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA