National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/6229

Target Organs and Levels of Evidence for TR-169

Bioassay of 2-Nitro-p-phenylenediamine for Possible Carcinogenicity (CASRN 5307-14-2)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2-Nitro-p-phenylenediamine
5307-14-2
08/31/1978In dyeing furs, semi-permanent and permanent hair dyes (HSDB 1990).Dosed-Feed
MR: 0,550,1100, FR: 0,1100,2200, M: 0,2200,4400 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Negative
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: (ADENOMA)


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