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https://ntp.niehs.nih.gov/go/8405

Target Organs and Levels of Evidence for TR-180

Bioassay of 4-Nitro-o-phenylenediamine for Possible Carcinogenicity (CASRN 99-56-9)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
4-Nitro-o-phenylenediamine
99-56-9
10/25/1978Hair dye; reagent for alpha-ketoacids, ascorbic and dehydroascorbic acids. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,375,750, M: 0,3750,7500 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative