National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/10316

Target Organs and Levels of Evidence for TR-201

Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Swiss-Webster Mice (Dermal Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2,3,7,8-Tetrachlorodibenzo-p-dioxin
1746-01-6
06/27/1980Present in certain herbicide and fungicide formulations, such as 2,4,5-T and pentachlorophenols; it has been tested for use in flameproofing polyesters & against insects and wood-destroying fungi. A contaminant created in the manufacture of agent orange. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Topical Application
FM: 0,.005, MM: 0,.001 UG/60 PER GROUP
IIT Research Institute

Levels of Evidence

Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Subcutaneous Tissue: FIBROSARCOMA 3/42 6/28
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Subcutaneous Tissue: FIBROSARCOMA 2/41 8/27


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