National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9792

Target Organs and Levels of Evidence for TR-215

Carcinogenesis Bioassay of Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Bisphenol A
80-05-7
10/15/1980Intermediate for resins, flame retardants, & rubber chemicals, fungicide (HSDB 1990). An intermediate used in the manufacture of epoxy, polycarbonate, and polyester-styrene resins.Dosed-Feed
R: 0,1000,2000, FM: 0,5000,10000, MM: 0,1000,5000 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 13/50 12/50 23/50
  • Testis: INTERSTITIAL CELL 35/49 9/50 46/49
Female Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LEUKEMIA 7/50 13/50 12/50
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Hematopoietic System: LYMPHOMA 2/49 9/50 5/50
Female Mice: Negative


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