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Target Organs and Levels of Evidence for TR-223

Carcinogenesis Studies of Eugenol (CASRN 97-53-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
02/18/1981Flavoring agent & fragrance, food additive, obtained from oil of cloves, fungicide, insect attractant (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
FR: 0,6000,12500, MR&M: 0,3000,6000 PPM/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 4/50 13/50 10/49 OR CARCINOMA 10/50 20/50 9/49 COMBINED 14/50 28/50 18/49
Female Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 4/49 3/49 OR CARCINOMA 2/50 3/49 6/49 COMBINED 2/50 7/49 9/49