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Target Organs and Levels of Evidence for TR-225

Carcinogenesis Bioassay of D & C Red No. 9 (CASRN 5160-02-1) in F344 Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
D & C red no. 9
02/18/1981Pigment in topical drugs and cosmeticsDosed-Feed
R: 0,1000,3000, M: 0,1000,2000 PPM/50 PER GROUP
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: SARCOMA 0/50 0/50 26/48
  • Liver: NEOPLASTIC NODULE 0/50 6/50 7/49
Female Rats: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: NEOPLASTIC NODULE 1/50 1/50 5/50
Male Mice: Negative
Female Mice: Negative