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Target Organs and Levels of Evidence for TR-233

Carcinogenesis Bioassay of 2-Biphenylamine Hydrochloride (CASRN 2185-92-4) in F344/N Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
2-Biphenylamine hydrochloride
2185-92-4
06/23/1981Intermediate in organic synthesis. A chemical intermediate used in the manufacture of C.I. Acid Red 15Dosed-Feed
0,1000,3000 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Equivocal
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA 0/50 2/50 3/50
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Vascular System (Unspecified): HEMANGIOSARCOMA 0/49 1/50 7/50