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Target Organs and Levels of Evidence for TR-235

Carcinogenesis Bioassay of Zearalenone (CASRN 17924-92-4) in F344/N Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
12/16/1981Non-steroid estrogenic mycotoxin (anabolic). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0, 25, OR 50 PPM M: 0, 50, OR 100 PPM
Southern Research Institute

Levels of Evidence

Male Rats: Negative
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pituitary Gland: ADENOMA 0/40 4/45 6/44
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pituitary Gland: ADENOMA 3/46 2/43 13/42
  • Liver: ADENOMA 0/50 2/49 7/49