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Target Organs and Levels of Evidence for TR-243

Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CASRN 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Trichloroethylene
79-01-6
09/22/1982Degreaser, dry cleaning solvent, manufacture or organic chemicals and pharmaceuticals, heat exchange liquid, diluent in paints and adhesives, caffeine extractant, textile processing, solvent in production of color additives for food, cosmetics, drugs (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,500,1000, M: 0,1000 MG/KG/50 PER GROUP
Papanicolaou Research Institute

Levels of Evidence

Male Rats: Inadequate Study
Female Rats: Negative
Male Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CARCINOMA 8/48 30/50
Female Mice: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 2/48 8/49; CARCINOMA 2/48 13/49