National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7164

Target Organs and Levels of Evidence for TR-245

Carcinogenesis Bioassay of Melamine (CASRN 108-78-1) in F344/N Rats and B6C3F1 Mice (Feed Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Melamine
108-78-1
06/16/1982Intermediate for amino resins and plastics, adhesives for wood, flooring, leather tanning (HSDB 1990)Dosed-Feed
FR: 0,4500,9000, MR&M: 0,2250,4500 PPM/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Positive
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Urinary Bladder: TRANSITIONAL CELL CARCINOMA 0/45 0/50 8/49
Female Rats: Negative
Male Mice: Negative
Female Mice: Negative


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