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Target Organs and Levels of Evidence for TR-250

Toxicology and Carcinogenesis Studies of Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Benzyl acetate
140-11-4
11/02/1984Soap fragrance; flavoring ingredient; solvent for cellulose acetate and cellulose nitrate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. And as a component of printing inks and varnish removers.Gavage
R: 0,250,500, M: 0,500,1000 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Acinar Cell: ADENOMA 22/50 27/50 37/49
Female Rats: No Evidence
Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 5/49 13/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 3/49 3/48 9/49 OR SQUAMOUS CELL CARCINOMA 1/49 1/48 2/49 COMBINED 4/49 4/48 11/49
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/50 0/50 6/50
  • Forestomach: SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/48