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Target Organs and Levels of Evidence for TR-266

Toxicology and Carcinogenesis Studies of Monuron (CASRN 150-68-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Monuron 150-68-5	06/29/1983	Dosed-Feed R: 0,750,1500, M: 0,5000,10000 PPM/50 PER GROUP	T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Clear Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Kidney Tubular Cell: ADENOMA 0/50 2/50 7/50 OR ADENOCARCINOMA 0/50 1/50 8/50 Liver: NEOPLASTIC NODULE 1/50 6/49 7/50 OR CARCINOMA 0/50 1/49 3/50 COMBINED 1/50 6/49 9/50
Non-Neoplastic Lesions	KIDNEY: CYTOMEGALY

Female Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	KIDNEY: CYTOMEGALY

Target Organs and Levels of Evidence for TR-266

Toxicology and Carcinogenesis Studies of Monuron (CASRN 150-68-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Levels of Evidence

Male Rats: Clear Evidence

Female Rats: No Evidence

Male Mice: No Evidence

Female Mice: No Evidence