National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/7602

Target Organs and Levels of Evidence for TR-266

Toxicology and Carcinogenesis Studies of Monuron (CASRN 150-68-5) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Monuron
150-68-5
06/29/1983Herbicide to control variety of annual and perennial plants. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Dosed-Feed
R: 0,750,1500, M: 0,5000,10000 PPM/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 2/50 7/50 OR ADENOCARCINOMA 0/50 1/50 8/50
  • Liver: NEOPLASTIC NODULE 1/50 6/49 7/50 OR CARCINOMA 0/50 1/49 3/50 COMBINED 1/50 6/49 9/50
Non-Neoplastic Lesions
  • KIDNEY: CYTOMEGALY
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • KIDNEY: CYTOMEGALY
Male Mice: No Evidence
Female Mice: No Evidence


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