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Isophorone: Target Organs and Levels of Evidence for TR-291

Toxicology and Carcinogenesis Studies of Isophorone (CASRN 78-59-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
11/02/1984Solvent. Chemical intermediate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
0,250,500 MG/KG/50 PER GROUP
Papanicolaou Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Kidney Tubular Cell: ADENOMA 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 3/50 1/50
  • Preputial Gland: CARCINOMA 0/50 0/50 5/50
Female Rats: No Evidence
Male Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 6/48 7/50 13/50 OR CARCINOMA 14/48 13/50 22/50 COMBINED 18/48 18/50 29/50
  • Subcutaneous Tissue: FIBROMA 0/48 2/50 3/50; FIBROSARCOMA 3/48 4/50 10/50; NEUROFIBROSARCOMA 1/48 0/50 0/50; SARCOMA 0/48 0/50 1/50
  • Hematopoietic System: LYMPHOMA 8/48 18/50 5/50
Female Mice: No Evidence