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Target Organs and Levels of Evidence for TR-303

Toxicology and Carcinogenesis Studies of 4-Vinylcyclohexene (CASRN 100-40-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
03/29/1985Manufacture of polymers and epoxy resins. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
0,200,400 MG/KG/50 PER GROUP
Litton Bionetics, Inc.

Levels of Evidence

Male Rats: Inadequate Study
Female Rats: Inadequate Study
Male Mice: Inadequate Study
Female Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Ovary: GRANULOSA CELL TUMOR 1/49 9/48 11/47 OR CARCINOMA 0/49 1/48 2/47 COMBINED 1/49 10/48 13/47
May Have Been Related
  • Adrenal Gland Cortex: ADENOMA 0/50 3/49 4/48