National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9580

Target Organs and Levels of Evidence for TR-315

Toxicology and Carcinogenesis Studies of Oxytetracycline Hydrochloride (CASRN 2058-46-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Oxytetracycline hydrochloride
2058-46-0
12/09/1985Antibiotic, antimicrobial, animal feed additiveDosed-Feed
R: 0,25000,50000 M: 0,6300,12500 PPM/50 PER GROUP
Physiological Research Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 10/50 18/50 24/50
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pituitary Gland: ADENOMA 9/50 17/50 30/50
Male Mice: No Evidence
Female Mice: No Evidence


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