National Toxicology Program

National Toxicology Program

Target Organs and Levels of Evidence for TR-334

Toxicology and Carcinogenesis Studies of 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
03/04/1987Chemical intermediate for dyes. Component of permanent hair products. Gavage
R: 0,100,200, M: 0,400,800 MG/KG/50 PER GROUP
Physiological Research Laboratory

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Pancreas Acinar Cell: ADENOMA 1/50 10/50 3/49
May Have Been Related
  • Preputial Gland: ADENOMA 3/50 2/50 1/50 OR CARCINOMA 0/50 0/50 4/50 COMBINED 3/50 2/50 5/50
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
May Have Been Related
  • Clitoral Gland: ADENOMA 2/50 1/50 7/50 OR CARCINOMA 1/50 2/50 0/50 COMBINED 3/50 3/50 7/50
Male Mice: No Evidence
Female Mice: No Evidence

NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.