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Target Organs and Levels of Evidence for TR-360

Toxicology and Carcinogenesis Studies of N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
N,N-Dimethylaniline 121-69-7	03/13/1989	Gavage R: 0,3,30, M: 0,15,30 MG/KG/50 PER GROUP	Springborn Inst. for Bioresearch, Inc.

Levels of Evidence

Male Rats: Some Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Spleen: SARCOMA 0/49 0/49 3/50 OR OSTEOSARCOMA 0/49 0/49 1/50 COMBINED 0/49 0/49 4/50
Non-Neoplastic Lesions	SPLEEN: FIBROSIS 5/49 2/49 22/50; HEMOSIDEROSIS 43/49 47/49 49/50; METAMORPHOSIS, FATTY 0/49 1/49 10/50

Female Rats: No Evidence

Male Mice: No Evidence

Female Mice: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 2/50 8/50