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Target Organs and Levels of Evidence for TR-360

Toxicology and Carcinogenesis Studies of N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
03/13/1989Dyes, intermediates; solvent; manufacture of vanillin; stabilizer (acid receptor). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,3,30, M: 0,15,30 MG/KG/50 PER GROUP
Springborn Inst. for Bioresearch, Inc.

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Spleen: SARCOMA 0/49 0/49 3/50 OR OSTEOSARCOMA 0/49 0/49 1/50 COMBINED 0/49 0/49 4/50
Non-Neoplastic Lesions
  • SPLEEN: FIBROSIS 5/49 2/49 22/50; HEMOSIDEROSIS 43/49 47/49 49/50; METAMORPHOSIS, FATTY 0/49 1/49 10/50
Female Rats: No Evidence
Male Mice: No Evidence
Female Mice: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: SQUAMOUS CELL PAPILLOMA 2/50 2/50 8/50