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Target Organs and Levels of Evidence for TR-364

Toxicology and Carcinogenesis Studies of Rhodamine 6G (C.I. Basic Red 1) (CASRN 989-38-8) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Rhodamine 6G
10/04/1988Dye for silk, cotton, wool, leather, plastic, paper and bast fiber. Tracing agent in water pollution studies.Dosed-Feed
R: 0, 120, 250, FM: 0, 500, 1000, MM: 0, 1000, 2000 PPM/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Skin: KERATOACANTHOMA 1/50 2/50 8/50
Female Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Adrenal Gland Medulla: PHEOCHROMOCYTOMA 3/50 3/50 8/50 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 0/50 2/50 COMBINED 3/50 3/50 10/50
Male Mice: No Evidence
Female Mice: No Evidence