National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/9122

Target Organs and Levels of Evidence for TR-382

Toxicology and Carcinogenesis Studies of Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Furfural
98-01-1
11/20/1989Intermediate In plastics preparation, wetting & flavoring agent, preparation of furfural alcohol, insecticide, fungicide, germicide, refining petroleum oils, solvent for cotton, dyes (HSDB 1990). Occurs in essential oils, coffee, rum (food, cosm tox). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Gavage
R: 0,30,60, M: 0,50,100,175 MG/KG/50 PER GROUP
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: CHOLANGIOCARCINOMA 0/50 0/50 2/50
Non-Neoplastic Lesions
  • LIVER: BILE DUCT, DYSPLASIA AND FIBROSIS
Female Rats: No Evidence
Male Mice: Clear Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 9/50 13/50 11/49 19/50; CARCINOMA 7/50 12/50 6/49 21/50
May Have Been Related
  • Kidney Tubular Cell: ADENOMA 0/50 0/50 1/49 1/50 OR CARCINOMA 0/50 1/50 0/49 0/50 COMBINED 0/50 1/50 1/49 1/50
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 1/50 3/50 5/50 8/50
May Have Been Related
  • Forestomach: SQUAMOUS CELL PAPILLOMA 1/50 0/50 1/50 6/50


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