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Target Organs and Levels of Evidence for TR-395

Toxicology and Carcinogenesis Studies of Probenecid (CASRN 57-66-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
11/20/1990Uricosuric agent for treatment of gout and gouty arthritis. Probenecid is also used as a therapeutic adjunct to enhance blood levels of penicillin and its action.Gavage
R&M:0,100,400 MG/KG/50 PER GROUP
T.S.I. Mason Laboratories, Inc.

Levels of Evidence

Male Rats: No Evidence
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Other Considerations
  • MAMMARY GLAND: FIBROADENOMA 24/50 23/50 5/50
Male Mice: No Evidence
Female Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 3/48 2/49 14/49, CARCINOMA 2/48 2/49 3/49, COMBINED 5/48 3/49 16/49