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Target Organs and Levels of Evidence for TR-447

Toxicology and Carcinogenesis Studies of Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Acetonitrile 75-05-8	06/21/1994	Inhalation R: 0, 100, 200, OR 400 PPM M: 0, 50, 100, OR 200 PPM ; 50/GROUP	Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence

Type	Organ/Tissue (Lesion)
Neoplastic Lesions	Liver: ADENOMA 0/48 1/47 1/48 3/48 OR CARCINOMA 1/48 0/47 0/48 3/48 COMBINED 1/48 1/47 1/48 5/48

Female Rats: No Evidence

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	FORESTOMACH: SQUAMOUS HYPERPLASIA

Female Mice: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	FORESTOMACH: SQUAMOUS HYPERPLASIA