National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/8672

Target Organs and Levels of Evidence for TR-447

Toxicology and Carcinogenesis Studies of Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Acetonitrile
75-05-8
06/21/1994Solvent in hydrocarbon extraction processes. Specialty solvent. Chemical intermediate. Separation of fatty acids from vegetable oils. Pharmaceuticals. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.Inhalation
R: 0, 100, 200, OR 400 PPM M: 0, 50, 100, OR 200 PPM ; 50/GROUP
Battelle Northwest Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADENOMA 0/48 1/47 1/48 3/48 OR CARCINOMA 1/48 0/47 0/48 3/48 COMBINED 1/48 1/47 1/48 5/48
Female Rats: No Evidence
Male Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS HYPERPLASIA
Female Mice: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • FORESTOMACH: SQUAMOUS HYPERPLASIA


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