Target Organs and Levels of Evidence for TR-489
Studies of Magnetic Field Promotion (DMBA Initiation) in Sprague-Dawley Rats (Gavage/Whole-Body Exposure Studies)
|Chemical (Study Title)|
|Peer Review Date||Primary Uses||Route/Exposure Levels||Study Laboratory|
|Magnetic fields + DMBA initiation promotion|
|03/11/1998||Special exposure study to evaluate the potential of 50/60 Hz magnetic fields to promote breast cancer in DMBA treated female Sprague Dawley rats.||Gavage, Whole Body Exposure|
13-WEEK STUDY (female rats only): 5 mg/rat DMBA @ 4 wkly intervals (total 20 mg DMBA) followed by 50 hz (1 gauss), 60 hz (1 gauss) or 50 hz (5 gauss)/18.5 hr/day. 26-WEEK STUDY (female rats only): 10 mg/rat DMBA followed by 50 hz (1 gauss), 60 hz (1 gauss), or 50 hz (5 gauss)/18.5 hr/day. Controls will receive vehicle (sesame oil) or DMBA with <1 milligauss. 100 per group.
|Battelle Northwest Laboratory|