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Target Organs and Levels of Evidence for TR-503

Toxicology and Carcinogenesis Study of Chloral Hydrate (Ad Libitum and Dietary Controlled) (CASRN 302-17-0) in Male B6C3F1 Mice (Gavage Study)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Chloral hydrate
302-17-0
05/18/2000Medication: CNS depressant & sedative agent; in liniments; used in pediatrics; intermediate in plastics, pesticides. Also found in drinking water as result of chlorination.Gavage
0, 25, 50, OR 100 MG/KG
National Center for Toxicological Research

Levels of Evidence

Male Mice: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Liver: ADEMONA OR CARCINOMA 16/48 25/48 23/47 22/48 (AD LIBITUM-FED GROUPS)
  • Liver: CARCINOMA 2/48 5/58 4/48 8/48 (DIETARY-CONTROLLED GROUPS)