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Target Organs and Levels of Evidence for TR-550

Toxicology and Carcinogenesis Studies of Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female B6C3F1 Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Cresols
1319-77-3
05/17/2007 Household disinfectant, paintbrush cleaner, in lubricating oils, fumigant, photographic developers, explosives, organic intermediate in production of coumarin, salicylaldehyde, synthetic resins, degreasing compounds, obtained from coal tar (HSDB 1990). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products. Dosed-Feed
R: 0, 1500, 5000, or 15,000 ppm and M: 0, 1000, 3000, or 10,000 ppm; 50/species/dose
Battelle Columbus Laboratory

Levels of Evidence

Male Rats: Equivocal Evidence
Type Organ/Tissue (Lesion)
May Have Been Related
  • Kidney Tubular Cell: Renal tubule adenoma (standard evaluation - 0/50 0/50 0/50 3/50; standard and extended evaluations combined - 0/50 0/50 0/50 4/50)
Non-Neoplastic Lesions
  • Kidney: pelvis, transitional epithelium, hyperplasia; severity of nephropathy
  • Nasal Cavity: goblet cell, hyperplasia; respiratory epithelium, hyperplasia; respiratory epithelium, metaplasia, squamous; inflammation
  • Liver: eosinophilic focus
Female Mice: Some Evidence
Type Organ/Tissue (Lesion)
Neoplastic Lesions
  • Forestomach: squamous cell papilloma (0/50 1/50 1/49 10/50)
Non-Neoplastic Lesions
  • Lung: bronchiole, hyperplasia
  • Nasal Cavity: respiratory epithelium, hyperplasia
  • Thyroid gland: follicular degeneration
  • Liver: eosinophilic focus