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Target Organs and Levels of Evidence for TR-565

Toxicology and Carcinogenesis Studies of Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats and B6C3F1 Mice (Feed studies)

Chemical (Study Title) CASRN	Peer Review Date	Route/Exposure Levels	Study Laboratory
Milk thistle extract 84604-20-6	11/19/2009	Dosed-Feed R&M: 0, 12500, 25000, OR 50000 PPM; 50/SEX/SPECIES	Southern Research Institute

Levels of Evidence

Male Rats: No Evidence

Female Rats: No Evidence

Type	Organ/Tissue (Lesion)
Non-Neoplastic Lesions	Liver: Clear cell focus, mixed cell focus
Decreased Incidences	Mammary Gland: Fibroadenoma

Male Mice: No Evidence

Type	Organ/Tissue (Lesion)
Decreased Incidences	Liver: Hepatocellular adenoma and carcinoma