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Target Organs and Levels of Evidence for TR-570

Toxicology and Carcinogenesis Studies of alpha/beta-Thujone (CASRN 76231-76-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Chemical (Study Title)
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
alpha/beta Thujone mixture
01/26/2011The essential oils derived from natural oil of cedar leaves in which Thujone occurs are used in herbal medicine and as flavorings, fragrances, and rodent and mite repellents. Thujone is banned as a direct food additive in the U.S. Thujone-containing plant oils are used as flavoring substances in the alcoholic drink industry.Gavage
R: 0, 12.5, 25, OR 50 MG/KG M: 0, 3, 6, 12, OR 25 MG/KG 50/SEX/SPECIES
Southern Research Institute

Levels of Evidence

Male Rats: Some Evidence
TypeOrgan/Tissue (Lesion)
Neoplastic Lesions
  • Preputial Gland: Carcinoma 1/49 0/49 5/50; adenoma or carcinoma 3/49 1/49 9/50
May Have Been Related
  • Adrenal Gland Medulla: Benign pheochromocytoma 6/50 850 12/49
Non-Neoplastic Lesions
  • Brain: necrosis, severity, pigmentation, severity
  • Spleen: pigmentation
  • Kidney: mineralization
Female Rats: No Evidence
TypeOrgan/Tissue (Lesion)
Non-Neoplastic Lesions
  • Brain: pigmentation, severity
  • Pituitary gland: pars distalis, atrophy, Rathkes cleft, dilatation
  • Spleen: pigmentation
Male Mice: No Evidence
Female Mice: No Evidence