National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/40442

Target Organs and Levels of Evidence for GMM-02

Toxicity Studies of Acesulfame Potassium (CASRN 55589-62-3) in FVB/N-TgN(v-Ha-ras)Led (Tg.AC) Hemizygous Mice and Carcinogenicity Studies of Acesulfame Potassium in B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Feed Studies)

Chemical (Study Title)
CASRN
Peer Review DatePrimary UsesRoute/Exposure LevelsStudy Laboratory
Transgenic model evaluation II (Acesulfame potassium)
55589-62-3
05/22/2003Artificial sweetenerDosed-Feed
0, 0.3, 1, or 3%; 15/sex/species/dose
BioReliance, Inc

Levels of evidence information for carcinogenesis and genetic toxicology studies of Acesulfame Potassium
Male p53 Haploinsufficient MiceFemale p53 Haploinsufficient Mice
39 Weeks39 Weeks
Levels of EvidenceNo Evidence No Evidence
Neoplastic LesionsNone None
Non-Neoplastic LesionsNoneNone
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