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Target Organs and Levels of Evidence for GMM-08

GMM-08 Toxicology and Carcinogenesis Study of Benzene (CASRN 71-43-2) in Genetically Modified Haploinsufficient p16Ink4a/p19Arf Mice (Gavage Study)

Chemical (Study Title)
Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory
Transgenic model evaluation II (Benzene)
08/28/2006 Transgenic mouse evaluation of benzene using the p16INKa(+/-) mouse model. Benzene is used in manufacture of medicinal chemicals, dyes, organic compounds, artificial leather, linoleum, oil cloth, varnishes, lacquers, solvent for waxes, resins, oils. Used to destroy screwworm larvae in wounds-veterinary use (Merck 1989) Gavage
0, 25, 50, 100, or 200 mg/kg
Battelle Columbus Laboratory

Levels of evidence information for the Carcinogenesis and Genetic Toxicology Studies of Benzene in Haploinsufficient p16Ink4a/p19Arf Mice (27 Weeks)
  Male Haploinsufficient p16Ink4a/p19Arf Mice Female Haploinsufficient p16Ink4a/p19Arf Mice
  27 Week 27 Week
Levels of Evidence Clear Evidence No Evidence
Neoplastic Lesions
  • Malignant lymphoma: 0/15, 0/15, 0/15, 0/15, 5/15
Non-Neoplastic Lesions
  • Bone marrow: atrophy; hemosiderin pigmentation
  • Spleen: hematopoietic cell proliferation; lymphoid follicle atrophy
  • Thymus: atrophy
  • Lymph node (mandibular): atrophy
  • Lymph node (mediastinal): atrophy
  • Lymph node (mesenteric): atrophy
  • Skin: pigmentation
  • Lymph node (mesenteric): atrophy
  • Skin: pigmentation