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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE Newsletter

January - June 2021


Desk with Open laptop and a stack of books.The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

ALTBIB moves to NTP website; ICCVAM Communities of Practice webinar on mixtures toxicity January 26; and FDA launches pilot program to support novel approaches to drug development.

Brian Berridge, D.V.M, Ph.D.Novel strategies for toxicological research discussed by NTP board

The NIEHS Division of the National Toxicology Program aims to share findings faster and tackle cardiovascular, neurodevelopmental diseases.

two people, shaving and brushing teethTriclosan worsens fatty liver disease in mice

The antibacterial compound, found in consumer products and some drinking water, worsened liver health in diabetic mice fed a high-fat diet.


ICCVAM logoThe NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

EPA finalizes guidance to waive toxicity tests on animal skin; New FDA report highlights progress in advancing alternatives; Minutes available from 2020 SACATM meeting; NICEATM and ICCVAM activities at SOT; Report available for 2019 Acute Toxicity Workshop; NICEATM research featured in special issue of Chemical Research in Toxicology.

two pregnant women talkingChemicals in the environment can harm maternal health

A pregnant woman’s exposures may affect the baby as well as her own longer-term health.


ICCVAM logoThe NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

Update available: EPA list of alternative test methods; EURL ECVAM issues status report on alternatives; Slides and video available from ICCVAM January 26 webinar; Special issue of Frontiers in In Vitro Toxicology on new approach methodologies; Chemical Research in Toxicology special issue focuses on computational toxicology; Workshop report available: Application of NAMs in support of read-across; and New toxicity prediction model provides broader and improved predictions.

Darlene Dixon, D.V.M., Ph.D.Dixon, Germolec, King-Herbert step into leadership of global scientific organizations

Recognition for outstanding NIEHS researchers is in the spotlight during Women’s History Month.

Amy Wang, Ph.D.Innovative research into cancer, mixtures headlines DNTP board meeting

Division of National Toxicology Program initiatives include environmental contributors to cancer, effects of combined chemical exposures.

a microphysiological systems (MPS) that models lung function for drug testingOrgans-on-a-chip for COVID-19 research group led by NTP center

Federal agencies collaborate on microphysiological systems to accelerate development of new treatments.

Nicole Kleinstreuer, Ph.D.Computational toxicology featured in special journal issue

Nicole Kleinstreuer co-edited a collection of computational toxicology articles in a special issue of the journal Chemical Research in Toxicology.


Integrated Chemical Environment logoThe NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

NICEATM releases ICE 3.3; DNTP postdoctoral fellow wins SOT specialty section Young Investigator award; NICEATM paper named Paper of the Year by SOT specialty section; and Recent publications.

Dori Germolec, Ph.D.NIEHS research front and center at Society of Toxicology meeting

Science communication, microplastics pollution, cannabis use during pregnancy, and more were discussed by institute scientists and grantees.

logo from Microbiome and Human Health Workshop, February 2021Microbiome workshop dives deep into expanding field

More than 500 researchers — from senior scientists to undergraduate students — participated in a virtual NIEHS workshop.

asphalt pavingNIOSH 50th anniversary honored by National Toxicology Program

Common goals and collaborative research signify the National Institute for Occupational Safety and Health’s participation in the NTP.


ICCVAM logoThe NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

Registration open for ICCVAM Public Forum May 27; CPSC issues proposed guidance on use of alternative methods, Comments due June 14; FDA to hold Science Forum May 26-27; NICEATM paper describes variability in skin irritation data; New review article describes non-animal approaches to eye irritation testing; NICEATM meeting activities.

John Bucher, Ph.D.John Bucher, who studied toxic agents from A to Z, retires from NIEHS

During almost four decades at the institute, he brought innovation to many complex issues, such as reducing animal use in research.

glass of water on a tree trunkHelp guide research on drinking water, from the source to the tap

NIEHS is working with the White House Office of Science and Technology Policy to boost knowledge about emerging contamination issues.

Kristen Ryan, Ph.D.Inhalation exposures, emerging chemicals addressed by NIEHS scientists

These research programs were front and center at the National Toxicology Program Board of Scientific Counselors meeting.

Kamel Mansouri, Ph.D.New predictive model may speed toxicity screens, reduce animal use

The freely available CATMoS combines the strengths of 139 different computational approaches to organic chemical screening.


ICCVAM logoThe NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

ICCVAM Public Forum held May 27; Save the date for SACATM in September; NICEATM to collaborate with Unilever on development of predictive model for skin sensitization; Paper describes global collaboration to develop predictive models for acute oral toxicity; Video, slides available from spring workshop on use of MPS for COVID research; Abstract submission open for ASCCT annual meeting, deadline July 15; and NICEATM activities at upcoming meetings.

July - December 2021

The Update Newsletter is produced by NTP Office of Liaison, Policy, and Review. The text is not copyrighted and can be reprinted without permission. If you use parts of the Update Newsletter in your publication, we ask that you provide us with a copy for our records. We welcome your comments and suggestions.

Director of Office of Liaison, Policy, and Review and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley