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Handbook for Preparing Report on Carcinogens Monographs

The handbook gives instructions for conducting the cancer hazard evaluation and preparing the monographs on substances under evaluation. The handbook includes methods for:

  • Planning for the evaluation
  • Conducting literature searches
  • Assessing study quality and sensitivity of individual studies
  • Synthesizing evidence across cancer studies to reach preliminary level of evidence conclusions
  • Evaluating mechanistic and other relevant data
  • Integrating evidence to reach a preliminary listing recommendation

The handbook is a living document and may be updated on a periodic basis.