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https://ntp.niehs.nih.gov/go/rochandbook

Handbook for Preparing Report on Carcinogens Monographs

The handbook gives instructions for conducting the cancer hazard evaluation and preparing the monographs on substances under evaluation. The handbook includes methods for:

  • Planning for the evaluation
  • Conducting literature searches
  • Assessing study quality and sensitivity of individual studies
  • Synthesizing evidence across cancer studies to reach preliminary level of evidence conclusions
  • Evaluating mechanistic and other relevant data
  • Integrating evidence to reach a preliminary listing recommendation

The handbook is a living document and may be updated on a periodic basis.

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