Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/bpaanalogues

Bisphenol A Structural Analogues

photo of inside of can and paper receipt

Topic Overview

Status: Evaluation completed

Background Information

Recent studies report widespread exposure to a variety of chemicals with structural or functional similarity to bisphenol A (BPA), often referred to as BPA analogues or derivatives. BPA analogues have been detected in foodstuffs, house dust, river and lake sediment, personal care products, and thermal paper. Several chlorinated and brominated derivatives of BPA are used as flame retardants. Importantly, BPA analogues have also been detected in human biological specimens.

In contrast to BPA, most BPA analogues are poorly understood with respect to potential toxicity for humans. To better understand the potential toxicity of BPA analogues, NTP conducted an analysis with two parts:

  1. A systematic review of available scientific literature for human, animal, and mechanistic toxicity of 24 BPA analogues
  2. Analysis of the structural and biological similarity of the 24 BPA analogues with each other, BPA, and the potent estrogen estradiol, using data from NTP's high-throughput screening programs Tox21/ToxCast.

The findings from both components are summarized in a research report released in October 2017.

Back to Top

Documents

Documents for Bisphenol A Structural Analogues
Date Document
Aug 01, 2015 NTP Protocol
Oct 01, 2017 NTP Research Report
Preferred Citation: NTP (National Toxicology Program). 2017. Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives. NTP Research Report 4. Research Triangle Park, NC: National Toxicology Program. https://doi.org/10.22427/NTP-RR-4
Back to Top

Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. For assistance, email us or use our contact form and identify the documents/pages for which access is required. We will assist you in accessing the content of these files. NIEHS has helpful information on accessibility.