On June 15, 2026, the National Institutes of Health (NIH) announced that moving forward, NICEATM will continue its important work as a division of the newly created NIH Office of Research Innovation, Validation, and Application (ORIVA). Soon, NICEATM content that you see on this webpage will be transitioned to the NIH ORIVA webpage. In the meantime, you can learn more about the new office and how it is structured.

https://ntp.niehs.nih.gov/go/838282

Strategic Roadmap: References

Birnbaum LS. 2013. 15 Years Out: Reinventing ICCVAM. Environ Health Perspec 121:a40-a40. 

ICCVAM Authorization Act. 2000. Public Law 106-545.  § 114 Stat. 2721, 2722, 2723, 2724 and 2725.

NIH (National Institutes of Health). 2017a. 82 FR 19071: Interagency coordinating committee on the validation of alternative methods; Notice of public meetings; Request for public input. Federal Register. 82(78):19071-19073.

NIH (National Institutes of Health). 2017b. 82 FR 20484: National Toxicology Program Board of Scientific Counselors; Announcement of meeting; Request for comments. Federal Register. 82(83):20484-20485.

NIH (National Institutes of Health). 2017c. 82 FR 37885: Scientific Advisory Committee on Alternative Toxicological Methods; Announcement of meeting; Request for comments. Federal Register. 82(155):37885-37887.

NRC (National Research Council). 2007. Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington, DC: The National Academies Press. 

OECD (Organisation for Economic Co-operation and Development). 2005. Guidance document on the validation and international acceptance of new or updated test methods for hazard assessment. Paris: OECD Publishing. ENV Series on Testing and Assessment. No. 34. 

Abbreviations and Acronyms

3RsReplace, reduce, and refine animal use in research and testing
EURL ECVAMEuropean Union Reference Laboratory for Alternatives to Animal Testing
GDGuidance document
IATAIntegrated approaches to testing and assessment
ICATMInternational Cooperation on Alternative Test Methods
ICCVAMInteragency Coordinating Committee on the Validation of Alternative Methods
NAMsNew approach methodologies
NICEATMNTP Interagency Center for the Evaluation of Alternative Toxicological Methods
NIEHSNational Institute of Environmental Health Sciences
NIHNational Institutes of Health
OECDOrganisation for Economic Co-operation and Development
SACATMScientific Advisory Committee on Alternative Toxicological Methods
Tox21Toxicology Testing in the 21st Century
ToxCastToxicity Forecaster (U.S. Environmental Protection Agency)
U.S.United States