| Sep 26, 2022 |
ICCVAM Biennial Progress Report 2020-2021 |
General |
| July 7, 2021 |
Prospective and Retrospective Evaluation of Eye Irritation Potential of Agrochemical Formulations |
Ocular |
| Mar 24, 2021 |
Measuring U.S. Federal Agency Progress Toward Implementation of Alternative Methods in Toxicity Testing |
General |
| Jul 22, 2020 |
ICCVAM Biennial Progress Report 2018-2019 |
General |
| Jun 29, 2020 |
Application of Non-animal Test Methods and Defined Approaches to Skin Sensitization Assessment of Isothiazolinone Compounds |
Immunotoxicity |
| Jul 18, 2018 |
ICCVAM Biennial Progress Report 2016-2017 |
General |
| Jan 30, 2018 |
A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States |
General |
| Aug 17, 2016 |
ICCVAM Biennial Progress Report 2014-2015 |
General |
| Jul 29, 2014 |
ICCVAM Biennial Progress Report 2012-2013 |
General |
| Oct 10, 2012 |
ICCVAM Test Method Evaluation Report: Identifying Chemical Eye Hazards with Fewer Animals |
Ocular |
| Jun 13, 2012 |
ICCVAM Biennial Progress Report 2010-2011 (NIH Publication No. 12-7873) |
General |
| Mar 06, 2012 |
Informational Brochure: "Nominations and Submissions to ICCVAM: A Guide for Test Method Developers and Sponsors" |
General |
| Feb 01, 2012 |
ICCVAM Test Method Evaluation Report - The LUMI-CELL® ER (BG1Luc ER TA) Test Method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals (NIH Publication No. 11-7850) |
Endocrine |
| Jun 30, 2011 |
ICCVAM Test Method Evaluation Report: Usefulness and Limitations of the Murine Local Lymph Node Assay for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans (NIH Publication No. 11-7709) |
Immunotoxicity |
| May 01, 2011 |
Independent Scientific Peer Review Panel Report: Evaluation of the LUMI-CELL ER® (BG1Luc ER TA) Test Method |
Endocrine |
| Sep 13, 2010 |
ICCVAM Test Method Evaluation Report: Recommendation to Discontinue Use of the Low Volume Eye Test for Ocular Safety Testing (NIH Publication No. 10-7515) |
Ocular |
| Sep 13, 2010 |
ICCVAM Test Method Evaluation Report on a Proposed In Vitro Testing Strategy for U.S. Environmental Protection Agency Ocular Hazard Classification and Labeling of Antimicrobial Cleaning Products (NIH Publication No. 10-7513) |
Ocular |
| Sep 13, 2010 |
ICCVAM Test Method Evaluation Report: Recommendations for Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints to Avoid or Minimize Pain and Distress in Ocular Safety Testing (NIH Publication No. 10-7514) |
Ocular |
| Sep 13, 2010 |
ICCVAM Test Method Evaluation Report - Volume 1: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products (NIH Publication No. 10-7553) |
Ocular |
| Sep 13, 2010 |
ICCVAM Test Method Evaluation Report - Volume 2: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products (NIH Publication No. 10-7553) |
Ocular |
| Jun 29, 2010 |
ICCVAM Test Method Evaluation Report on Using the Murine Local Lymph Node Assay for Testing Pesticide Formulations, Metals, Substances in Aqueous Solutions, and Other Products (NIH Publication No. 10-7512) |
Immunotoxicity |
| Jun 29, 2010 |
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: BrdU-ELISA
A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7552) |
Immunotoxicity |
| Jun 29, 2010 |
ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: DA
A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7551) |
Immunotoxicity |
| Jun 10, 2010 |
ICCVAM Biennial Progress Report 2008-2009 (NIH Publication No. 10-7612) |
General |
| Jul 13, 2009 |
Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of Alternative Ocular Safety Testing Methods and Approaches |
Ocular |
| Jun 01, 2009 |
Independent Scientific Peer Review Panel Report - Updated Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products |
Immunotoxicity |
| Mar 01, 2009 |
Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations
Contact NICEATM to obtain this document
|
Acute Systemic Toxicity |
| Mar 01, 2009 |
ICCVAM Test Method Evaluation Report - The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 09-6439) |
Immunotoxicity |
| Jan 01, 2009 |
Recommended Performance Standards: Murine Local Lymph Node Assay (NIH Publication No. 09-7357) |
Immunotoxicity |
| Oct 23, 2008 |
Biennial Progress Report: Interagency Coordinating Committee on the Validation of Alternative Methods - 2006-2007 (NIH Publication No. 08-6529) |
General |
| May 20, 2008 |
Independent Scientific Peer Review Panel Report - Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products |
Immunotoxicity |
| May 01, 2008 |
ICCVAM Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6391) |
Pyrogenicity |
| May 01, 2008 |
ICCVAM Test Method Evaluation Report: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6392) |
Pyrogenicity |
| Mar 28, 2008 |
Report on the ICCVAM-NICEATM/ECVAM Scientific Workshop on Alternative Methods to Refine, Reduce or Replace the Mouse LD50 Assay for Botulinum Toxin Testing (NIH Publication No. 08-6416) |
Biologics |
| Feb 05, 2008 |
The NICEATM-ICCVAM Five-Year Plan (2008-2012) (NIH Publication No. 08-6410) |
General |
| Apr 30, 2007 |
Independent Peer Review Panel Report: Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products |
Pyrogenicity |
| Nov 26, 2006 |
Biennial Progress Report 2004-2005 - Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 06-4516) |
General |
| Nov 01, 2006 |
Background Review Document - Volume 1: In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity (NIH Publication No. 07-4518) |
Acute Systemic Toxicity |
| Nov 01, 2006 |
Background Review Document - Volume 2: In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity (NIH Publication No. 07-4518) |
Acute Systemic Toxicity |
| Nov 01, 2006 |
ICCVAM Test Method Evaluation Report - In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives (NIH Publication No. 07-4517) |
Ocular |
| Nov 01, 2006 |
ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests (NIH Publication No. 07-4519) |
Acute Systemic Toxicity |
| Oct 16, 2006 |
NICEATM Pre-Screen Evaluation of the In Vitro Endocrine Disruptor Assay (Robotic MCF-7 Cell Proliferation Assay of Estrogenic Activity) |
Endocrine |
| Sep 28, 2006 |
Finalized Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors |
Endocrine |
| Jun 01, 2006 |
Peer Review Panel Report: The Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing |
Acute Systemic Toxicity |
| Mar 12, 2006 |
Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Rabbit Eye (IRE) Test Method (NIH Publication No. 06-4514)
Contact NICEATM to obtain this document |
Ocular |
| Mar 12, 2006 |
Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method (NIH Publication No. 06-4512)
Contact NICEATM to obtain this document |
Ocular |
| Mar 12, 2006 |
Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye (ICE) Test Method (NIH Publication No. 06-4513)
Contact NICEATM to obtain this document |
Ocular |
| Mar 12, 2006 |
Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Hen's Egg Test: Chrorioallantoic Membrane (Het-CAM) Test Method (NIH Publication No. 06-4515)
Contact NICEATM to obtain this document |
Ocular |
| Nov 12, 2005 |
Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants - ADDENDUM |
Ocular |
| Mar 12, 2005 |
Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants |
Ocular |
| May 10, 2004 |
Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion (NIH Publication No. 04-4510) |
Dermal |
| Feb 11, 2004 |
Interagency Coordinating Committee on the Validation of Alternative Methods: Mission, Vision and Strategic Priorities |
General |
| Dec 19, 2003 |
ICCVAM Biennial Progress Report 2002-2003 (NIH Publication No. 04-4509) |
General |
| Sep 01, 2003 |
ICCVAM Guidelines for the Nomination and Submission of New, Revised and Alternative Test Methods (NIH Publication No. 03-4508) |
General |
| May 01, 2003 |
ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays (NIH Publication No. 03-4503) |
Endocrine |
| Sep 01, 2002 |
Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Binding Assays (NIH Publication No. 03-4504)
Contact NICEATM to obtain this document |
Endocrine |
| Sep 01, 2002 |
Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4505)
Contact NICEATM to obtain this document |
Endocrine |
| Sep 01, 2002 |
Expert Panel Evaluation of the Validation Status of In Vitro Test Methods for Detecting Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays |
Endocrine |
| Sep 01, 2002 |
Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4507)
Contact NICEATM to obtain this document |
Endocrine |
| Sep 01, 2002 |
Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Binding Assays (NIH Publication No. 03-4506)
Contact NICEATM to obtain this document |
Endocrine |
| Jul 22, 2002 |
ICCVAM Evaluation of EPISKIN(TM), EpiDerm(TM), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for Assessing Dermal Corrosivity Potential of Chemicals (NIH Publication No. 02-4502) |
Dermal |
| Dec 19, 2001 |
Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) |
General |
| Nov 30, 2001 |
The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals - Volume 1 (NIH Publication No. 02-4501) |
Acute Systemic Toxicity |
| Nov 30, 2001 |
The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals - Volume 2 (NIH Publication No. 02-4501) |
Acute Systemic Toxicity |
| Aug 17, 2001 |
Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Results of an International Workshop Organized by ICCVAM and NICEATM (NIH Publication 01-4499) |
Acute Systemic Toxicity |
| Aug 12, 2001 |
Background Review Document - EPISKIN(TM), EpiDerm(TM)(EPI-200), and Rat Skin Transcutaneous Electrical Resistance (TER) - In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals |
Dermal |
| Aug 01, 2001 |
Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity: Based on Recommendations from an International Workshop Organized by ICCVAM and NICEATM |
Acute Systemic Toxicity |
| Dec 19, 2000 |
ICCVAM Authorization Act of 2000 (Public Law 106-545) |
General |
| Mar 10, 2000 |
Background Review Document: Frog Embryo Teratogenesis Assay -- Xenopus (FETAX) |
Developmental/Reproductive |
| Jun 01, 1999 |
Corrositex(R): An In Vitro Test Method for Assessing Dermal Corrosivity Potential of Chemicals. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4495) |
Dermal |
| Mar 11, 1999 |
The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4494) |
Immunotoxicity |
| Mar 01, 1997 |
Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 97-3981) |
General |
