On June 15, 2026, the National Institutes of Health (NIH) announced that moving forward, NICEATM will continue its important work as a division of the newly created NIH Office of Research Innovation, Validation, and Application (ORIVA). Soon, NICEATM content that you see on this webpage will be transitioned to the NIH ORIVA webpage. In the meantime, you can learn more about the new office and how it is structured.

https://ntp.niehs.nih.gov/go/iccvam-rpts

Reports

Publication DateTitleCategory
Oct 28, 2026ICCVAM 2024-2025 Biennial Progress ReportGeneral
Oct 22, 2026New Approach Methodologies for Characterizing Potential Human and Environmental Health Effects of PFAS: A Report of the ICCVAM Per- and Polyfluoroalkyl Substances WorkgroupGeneral
Aug 21, 2025Report on the Validation of the Electrophilic Allergen Screening Assay (EASA) for the Identification of Potential Skin SensitizersImmunotoxicity
Jun 30, 2025Evaluation of the GARD™skin Sensitization Test Method Using Substances of Regulatory InterestImmunotoxicity
May 28, 2025Evaluation of Substances of Regulatory Interest Using Non-Animal Skin Sensitization Test MethodsImmunotoxicity
Jan 15, 2025Addendum to the Prospective and Retrospective Evaluation of the Eye Irritation Potential of Agrochemical FormulationsOcular
Sep 5, 2024ICCVAM Biennial Progress Report 2022-2023General
Mar 1, 2024Validation, Qualification, and Regulatory Acceptance of New Approach MethodologiesGeneral
Sep 26, 2022ICCVAM Biennial Progress Report 2020-2021General
July 7, 2021Prospective and Retrospective Evaluation of Eye Irritation Potential of Agrochemical FormulationsOcular
Mar 24, 2021Measuring U.S. Federal Agency Progress Toward Implementation of Alternative Methods in Toxicity TestingGeneral
Jul 22, 2020ICCVAM Biennial Progress Report 2018-2019General
Jun 29, 2020Application of Non-animal Test Methods and Defined Approaches to Skin Sensitization Assessment of Isothiazolinone CompoundsImmunotoxicity
Jul 18, 2018ICCVAM Biennial Progress Report 2016-2017General
Jan 30, 2018A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United StatesGeneral
Aug 17, 2016ICCVAM Biennial Progress Report 2014-2015General
Jul 29, 2014ICCVAM Biennial Progress Report 2012-2013General
Oct 10, 2012ICCVAM Test Method Evaluation Report: Identifying Chemical Eye Hazards with Fewer AnimalsOcular
Jun 13, 2012ICCVAM Biennial Progress Report 2010-2011 (NIH Publication No. 12-7873)General
Mar 06, 2012Informational Brochure: "Nominations and Submissions to ICCVAM: A Guide for Test Method Developers and Sponsors"General
Feb 01, 2012ICCVAM Test Method Evaluation Report - The LUMI-CELL® ER (BG1Luc ER TA) Test Method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals (NIH Publication No. 11-7850)Endocrine
Jun 30, 2011ICCVAM Test Method Evaluation Report: Usefulness and Limitations of the Murine Local Lymph Node Assay for Potency Categorization of Chemicals Causing Allergic Contact Dermatitis in Humans (NIH Publication No. 11-7709)Immunotoxicity
May 01, 2011Independent Scientific Peer Review Panel Report: Evaluation of the LUMI-CELL ER® (BG1Luc ER TA) Test MethodEndocrine
Sep 13, 2010ICCVAM Test Method Evaluation Report: Recommendation to Discontinue Use of the Low Volume Eye Test for Ocular Safety Testing (NIH Publication No. 10-7515)Ocular
Sep 13, 2010ICCVAM Test Method Evaluation Report on a Proposed In Vitro Testing Strategy for U.S. Environmental Protection Agency Ocular Hazard Classification and Labeling of Antimicrobial Cleaning Products (NIH Publication No. 10-7513)Ocular
Sep 13, 2010ICCVAM Test Method Evaluation Report: Recommendations for Routine Use of Topical Anesthetics, Systemic Analgesics, and Humane Endpoints to Avoid or Minimize Pain and Distress in Ocular Safety Testing (NIH Publication No. 10-7514)Ocular
Sep 13, 2010ICCVAM Test Method Evaluation Report - Volume 1: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products (NIH Publication No. 10-7553)Ocular
Sep 13, 2010ICCVAM Test Method Evaluation Report - Volume 2: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products (NIH Publication No. 10-7553)Ocular
Jun 29, 2010ICCVAM Test Method Evaluation Report on Using the Murine Local Lymph Node Assay for Testing Pesticide Formulations, Metals, Substances in Aqueous Solutions, and Other Products (NIH Publication No. 10-7512)Immunotoxicity
Jun 29, 2010ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: BrdU-ELISA
A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7552)		Immunotoxicity
Jun 29, 2010ICCVAM Test Method Evaluation Report on the Murine Local Lymph Node Assay: DA
A Nonradioactive Alternative Test Method to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 10-7551)		Immunotoxicity
Jun 10, 2010ICCVAM Biennial Progress Report 2008-2009 (NIH Publication No. 10-7612)General
Jul 13, 2009Independent Scientific Peer Review Panel Report: Evaluation of the Validation Status of Alternative Ocular Safety Testing Methods and ApproachesOcular
Jun 01, 2009Independent Scientific Peer Review Panel Report - Updated Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and ProductsImmunotoxicity
Mar 01, 2009Report on the ICCVAM-NICEATM/ECVAM/JaCVAM Scientific Workshop on Acute Chemical Safety Testing: Advancing In Vitro Approaches and Humane Endpoints for Systemic Toxicity Evaluations
Contact NICEATM to obtain this document		Acute Systemic Toxicity
Mar 01, 2009ICCVAM Test Method Evaluation Report - The Reduced Murine Local Lymph Node Assay: An Alternative Test Method Using Fewer Animals to Assess the Allergic Contact Dermatitis Potential of Chemicals and Products (NIH Publication No. 09-6439)Immunotoxicity
Jan 01, 2009Recommended Performance Standards: Murine Local Lymph Node Assay (NIH Publication No. 09-7357)Immunotoxicity
Oct 23, 2008Biennial Progress Report: Interagency Coordinating Committee on the Validation of Alternative Methods - 2006-2007 (NIH Publication No. 08-6529)General
May 20, 2008Independent Scientific Peer Review Panel Report - Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and ProductsImmunotoxicity
May 01, 2008ICCVAM Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6391)Pyrogenicity
May 01, 2008ICCVAM Test Method Evaluation Report: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products (NIH Publication No. 08-6392)Pyrogenicity
Mar 28, 2008Report on the ICCVAM-NICEATM/ECVAM Scientific Workshop on Alternative Methods to Refine, Reduce or Replace the Mouse LD50 Assay for Botulinum Toxin Testing (NIH Publication No. 08-6416)Biologics
Feb 05, 2008The NICEATM-ICCVAM Five-Year Plan (2008-2012) (NIH Publication No. 08-6410)General
Apr 30, 2007Independent Peer Review Panel Report: Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other ProductsPyrogenicity
Nov 26, 2006Biennial Progress Report 2004-2005 - Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 06-4516)General
Nov 01, 2006Background Review Document - Volume 1: In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity (NIH Publication No. 07-4518)Acute Systemic Toxicity
Nov 01, 2006Background Review Document - Volume 2: In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity (NIH Publication No. 07-4518)Acute Systemic Toxicity
Nov 01, 2006ICCVAM Test Method Evaluation Report - In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives (NIH Publication No. 07-4517)Ocular
Nov 01, 2006ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests (NIH Publication No. 07-4519)Acute Systemic Toxicity
Oct 16, 2006NICEATM Pre-Screen Evaluation of the In Vitro Endocrine Disruptor Assay (Robotic MCF-7 Cell Proliferation Assay of Estrogenic Activity)Endocrine
Sep 28, 2006Finalized Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine DisruptorsEndocrine
Jun 01, 2006Peer Review Panel Report: The Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity TestingAcute Systemic Toxicity
Mar 12, 2006Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Rabbit Eye (IRE) Test Method (NIH Publication No. 06-4514)
Contact NICEATM to obtain this document		Ocular
Mar 12, 2006Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method (NIH Publication No. 06-4512)
Contact NICEATM to obtain this document		Ocular
Mar 12, 2006Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye (ICE) Test Method (NIH Publication No. 06-4513)
Contact NICEATM to obtain this document		Ocular
Mar 12, 2006Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Hen's Egg Test: Chrorioallantoic Membrane (Het-CAM) Test Method (NIH Publication No. 06-4515)
Contact NICEATM to obtain this document		Ocular
Nov 12, 2005Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants - ADDENDUMOcular
Mar 12, 2005Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe IrritantsOcular
May 10, 2004Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion (NIH Publication No. 04-4510)Dermal
Feb 11, 2004Interagency Coordinating Committee on the Validation of Alternative Methods: Mission, Vision and Strategic PrioritiesGeneral
Dec 19, 2003ICCVAM Biennial Progress Report 2002-2003 (NIH Publication No. 04-4509)General
Sep 01, 2003ICCVAM Guidelines for the Nomination and Submission of New, Revised and Alternative Test Methods (NIH Publication No. 03-4508)General
May 01, 2003ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays (NIH Publication No. 03-4503)Endocrine
Sep 01, 2002Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Binding Assays (NIH Publication No. 03-4504)
Contact NICEATM to obtain this document		Endocrine
Sep 01, 2002Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4505)
Contact NICEATM to obtain this document		Endocrine
Sep 01, 2002Expert Panel Evaluation of the Validation Status of In Vitro Test Methods for Detecting Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation AssaysEndocrine
Sep 01, 2002Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Transcriptional Activation Assays (NIH Publication No. 03-4507)
Contact NICEATM to obtain this document		Endocrine
Sep 01, 2002Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Binding Assays (NIH Publication No. 03-4506)
Contact NICEATM to obtain this document		Endocrine
Jul 22, 2002ICCVAM Evaluation of EPISKIN(TM), EpiDerm(TM), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for Assessing Dermal Corrosivity Potential of Chemicals (NIH Publication No. 02-4502)Dermal
Dec 19, 2001Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)General
Nov 30, 2001The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals - Volume 1 (NIH Publication No. 02-4501)Acute Systemic Toxicity
Nov 30, 2001The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals - Volume 2 (NIH Publication No. 02-4501)Acute Systemic Toxicity
Aug 17, 2001Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Results of an International Workshop Organized by ICCVAM and NICEATM (NIH Publication 01-4499)Acute Systemic Toxicity
Aug 12, 2001Background Review Document - EPISKIN(TM), EpiDerm(TM)(EPI-200), and Rat Skin Transcutaneous Electrical Resistance (TER) - In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of ChemicalsDermal
Aug 01, 2001Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity: Based on Recommendations from an International Workshop Organized by ICCVAM and NICEATMAcute Systemic Toxicity
Dec 19, 2000ICCVAM Authorization Act of 2000 (Public Law 106-545)General
Mar 10, 2000Background Review Document: Frog Embryo Teratogenesis Assay -- Xenopus (FETAX)Developmental/Reproductive
Jun 01, 1999Corrositex(R): An In Vitro Test Method for Assessing Dermal Corrosivity Potential of Chemicals. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4495)Dermal
Mar 11, 1999The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH Publication No. 99-4494)Immunotoxicity
Mar 01, 1997Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods (NIH Publication No. 97-3981)General