Research & Testing

NTP immunotoxicity, neurobehavioral, reproductive, and toxicology/carcinogenicity studies, as well as general chemistry and modified one-generation protocols, are conducted according to the specifications listed below.

Chemistry

Chemistry Specifications and Criteria
Specification/CriteriaLast Updated
Chemistry Specifications2018

Developmental & Reproductive Toxicity

Developmental and Reproductive Toxicity Specifications and Criteria
Specification/CriteriaLast Updated
Explanation of Levels of Evidence for Developmental Toxicity2009
Explanation of Levels of Evidence for Reproductive Toxicity2009

Health Effects Assessments

Health Effects Assessments Specifications and Criteria
Specification/CriteriaLast Updated
Handbook for Preparing Report on Carcinogens Monographs2025
OHAT Handbook2019
OHAT Risk of Bias Tool2015
Report on Carcinogens Listing Criteria2016

Immunotoxicity

Immunotoxicity Specifications and Criteria
Specification/CriteriaLast Updated
Explanation of Levels of Evidence for Immune System Toxicity2009
NTP Immunotoxicity Study Pathology Specifications2016

Statistical Procedures

Statistical Procedures Specifications and Criteria
Specification/CriteriaLast Updated
Statistical Procedures2019

Toxicology/Carcinogenicity

Toxicology/Carcinogenicity Specifications and Criteria
Specification/CriteriaLast Updated
Explanation of Levels of Evidence of Carcinogenic Activity1986
Toxicology Specifications2023

Transcriptomics

Transcriptomics Specifications and Criteria
Specification/CriteriaLast Updated
NTP Approach to Genomic Dose-Response Modeling2018