TDMS Study 92013-03 Pathology Tables
NTP Experiment-Test: 92013-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:40:33
90-DAY SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 822-36-6
Lock Date: 01/12/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 92013-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 3 2 2 2 2
Accidently Killed 7 8 7 8 8 10
Animals Examined Microscopically 10 2 5 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (2) (10) (10) (10)
Congestion 1 (50%)
Hepatodiaphragmatic Nodule 1 (10%) 1 (100%) 1 (50%) 1 (10%) 1 (10%)
Inflammation, Focal 1 (10%) 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 1 (10%) 8 (80%)
Mesentery (1)
Fat, Necrosis 1 (100%)
Pancreas (10) (1) (10)
Acinus, Degeneration, Focal 1 (10%) 4 (40%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (1) (10)
Inflammation, Focal 3 (30%)
Artery, Inflammation 1 (10%)
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ENDOCRINE SYSTEM
Pituitary Gland (10) (1) (10)
Pars Distalis, Cyst 1 (10%)
Thyroid Gland (10) (1) (10)
Follicle, Cyst 1 (10%)
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GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 92013-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (1) (1) (10)
Cyst 1 (100%)
Bilateral, Cyst 1 (10%)
Bursa, Cyst 1 (10%)
Uterus (10) (4) (10) (10) (10)
Bilateral, Cyst 1 (25%)
Bilateral, Dilatation 3 (30%) 3 (75%) 1 (10%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (10) (1) (10)
Infiltration Cellular, Focal, Histiocyte 1 (10%)
Lymph Node, Mandibular (10) (1) (9)
Hemorrhage 2 (22%)
Lymph Node, Mesenteric (10) (1) (10)
Infiltration Cellular, Histiocyte 1 (10%)
Spleen (10) (1) (10)
Hematopoietic Cell Proliferation 1 (10%)
Pigmentation, Diffuse 2 (20%) 1 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1) (1) (5) (10)
Congestion 1 (100%)
Inflammation, Focal 5 (50%) 1 (100%) 5 (100%) 2 (20%)
Nose (10) (1) (10)
Olfactory Epithelium, Inflammation,
Suppurative 1 (10%)
Respiratory Epithelium, Inflammation,
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 92013-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 92013-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 10 9 9 10 3 2
Accidently Killed 1 1 7 7
Animals Examined Microscopically 10 3 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (9)
Inflammation, Focal 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 1 (10%) 3 (30%) 10 (100%) 10 (100%) 9 (100%)
Pancreas (10) (9)
Acinus, Degeneration, Focal 2 (22%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (9)
Inflammation, Focal 3 (30%) 4 (44%)
Artery, Inflammation 1 (10%) 1 (11%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10)
Hypospermia 9 (90%)
Prostate (10) (1) (10) (10) (10) (10)
Atrophy 1 (100%) 1 (10%) 2 (20%) 8 (80%) 8 (80%)
Inflammation 2 (20%) 3 (30%) 1 (10%) 8 (80%)
Testes (10) (1) (10) (10) (10) (10)
Degeneration 1 (10%) 1 (100%) 4 (40%) 9 (90%) 9 (90%)
Hypospermia 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 92013-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (8)
Hemorrhage 2 (20%)
Lymph Node, Mesenteric (10) (10)
Hemorrhage 2 (20%)
Infiltration Cellular, Histiocyte 1 (10%)
Spleen (10) (1) (9)
Congestion 1 (100%)
Hematopoietic Cell Proliferation 1 (10%)
Thymus (10) (9)
Hemorrhage 3 (33%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (2) (4) (1) (6) (9)
Inflammation, Focal 4 (40%) 2 (100%) 4 (100%) 1 (100%) 6 (100%) 8 (89%)
Alveolar Epithelium, Hyperplasia 1 (17%)
Nose (10) (9)
Respiratory Epithelium, Inflammation,
Suppurative 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 92013-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:40:33
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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