TDMS Study 93021-03 Pathology Tables
NTP Experiment-Test: 93021-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:15:45
13 WEEK SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 538-75-0
Lock Date: 05/17/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93021-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:15:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 10
Survivors
Accidently Killed 2
Terminal Sacrifice 8 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (10) (10)
Hepatodiaphragmatic Nodule 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10)
Cardiomyopathy 1 (10%) 1 (10%) 4 (40%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (10) (10) (9)
Pars Distalis, Cyst 1 (11%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (9) (10)
Inflammation, Chronic Active, Focal 1 (11%)
Uterus (10) (1) (1) (10) (10)
Hydrometra 1 (100%) 1 (100%) 2 (20%)
Bilateral, Hydrometra 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 93021-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:15:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Hyperplasia, Diffuse 1 (10%) 9 (90%)
Hyperplasia, Focal, Histiocytic 4 (40%) 4 (40%) 2 (20%) 1 (10%)
Lymph Node (1)
Hyperplasia, Diffuse, Lymphoid 1 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Control, Inflammation, Chronic Active 1 (10%) 1 (10%) 2 (20%)
Dermis, Skin, Site of Application, Edema,
Focal 1 (10%)
Dermis, Skin, Site of Application,
Inflammation, Chronic Active 1 (10%)
Epidermis, Control, Hyperplasia 1 (10%) 1 (10%) 1 (10%) 1 (10%)
Epidermis, Control, Necrosis 1 (10%)
Epidermis, Skin, Site of Application,
Hyperplasia 3 (30%) 7 (70%) 7 (70%) 10 (100%) 10 (100%)
Epidermis, Skin, Site of Application,
Necrosis 1 (10%) 3 (30%)
Epidermis, Skin, Site of Application,
Necrosis, Focal 1 (10%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 1 (10%) 5 (50%) 7 (70%)
Skin, Site of Application, Inflammation,
Acute 1 (10%)
Skin, Site of Application, Inflammation,
Chronic Active 4 (40%) 4 (40%) 9 (90%) 9 (90%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 93021-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:15:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (9) (10) (9) (10) (10)
Inflammation, Chronic Active, Focal 8 (80%) 9 (100%) 6 (60%) 7 (78%) 7 (70%) 2 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10)
Nephropathy 2 (20%) 1 (10%) 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 93021-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:15:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 2
Moribund Sacrifice 8
Survivors
Terminal Sacrifice 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10)
Hepatodiaphragmatic Nodule 1 (10%)
Inflammation, Chronic Active 1 (10%)
Stomach, Forestomach (10) (10) (10)
Hyperplasia, Atypical, Focal 1 (10%)
Inflammation, Acute, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10) (10)
Cardiomyopathy 1 (10%) 3 (30%) 2 (20%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10) (10)
Inflammation, Chronic, Focal 1 (10%) 1 (10%)
Inflammation, Chronic Active, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 93021-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:15:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Hyperplasia, Diffuse 10 (100%)
Spleen (10) (10) (10) (10) (10) (10)
Depletion Cellular, Diffuse 1 (10%)
Hematopoietic Cell Proliferation, Focal 1 (10%) 1 (10%) 1 (10%) 2 (20%) 1 (10%)
Thymus (10) (10) (10)
Atrophy 1 (10%)
Necrosis, Diffuse 2 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Control, Inflammation, Chronic Active 3 (30%) 2 (20%)
Epidermis, Control, Hyperplasia 5 (50%) 1 (10%)
Epidermis, Control, Necrosis 1 (10%) 1 (10%)
Epidermis, Skin, Site of Application,
Hyperplasia 1 (10%) 3 (30%) 9 (90%) 10 (100%) 10 (100%)
Epidermis, Skin, Site of Application,
Hyperplasia, Focal 1 (10%)
Epidermis, Skin, Site of Application,
Necrosis 6 (60%)
Sebaceous Gland, Skin, Site of Application,
Hyperplasia 1 (10%) 1 (10%) 4 (40%) 7 (70%) 6 (60%)
Skin, Site of Application, Inflammation,
Acute, Diffuse 1 (10%)
Skin, Site of Application, Inflammation,
Chronic Active 1 (10%) 1 (10%) 7 (70%) 9 (90%)
Skin, Site of Application, Inflammation,
Granulomatous 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (10) (10) (10) (10) (10) (10)
Hemorrhage 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 93021-03 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:15:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 0.75 1.5 3.0 6.0 12.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (8) (10) (10)
Congestion, Diffuse 2 (20%)
Inflammation, Chronic Active, Focal 8 (80%) 8 (80%) 7 (70%) 7 (88%) 9 (90%) 3 (30%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10)
Nephropathy 6 (60%) 5 (50%) 2 (20%)
Renal Tubule, Degeneration, Focal 1 (10%)
Urinary Bladder (10) (10) (10)
Hemorrhage 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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