TDMS Study 92013-04 Pathology Tables
NTP Experiment-Test: 92013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:49:10
90-DAY SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 822-36-6
Lock Date: 01/12/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 92013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:49:10
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B6C3F1 MICE FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 7
Survivors
Terminal Sacrifice 9 9 8 9 10 2
Accidently Killed 1 1 2 1 1
Animals Examined Microscopically 10 9 6 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (9) (6) (10) (10) (10)
Infiltration Cellular, Mixed Cell 1 (10%) 1 (17%) 1 (10%)
Centrilobular, Vacuolization Cytoplasmic 3 (30%)
Periportal, Vacuolization Cytoplasmic 6 (60%) 9 (100%) 5 (83%) 5 (50%) 3 (30%)
Salivary Glands (10) (10) (7)
Infiltration Cellular, Lymphocyte 2 (20%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10) (9)
Valve, Pigmentation 1 (10%)
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Clitoral Gland (8) (7) (5)
Cyst 1 (13%)
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a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 92013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:49:10
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (7)
Hemorrhage 1 (10%)
Hyperplasia, Lymphoid 1 (10%)
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INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (7)
Infiltration Cellular, Mixed Cell 1 (10%)
Perivascular, Infiltration Cellular, Mixed
Cell 2 (20%) 1 (14%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Urinary Bladder (10) (10) (10)
Infiltration Cellular, Mixed Cell 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 92013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:49:10
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 10 10 9
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Infiltration Cellular, Mixed Cell 3 (30%)
Centrilobular, Vacuolization Cytoplasmic 1 (10%) 2 (20%)
Periportal, Vacuolization Cytoplasmic 10 (100%) 10 (100%) 10 (100%) 10 (100%) 9 (90%) 7 (70%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (1) (10)
Cyst 6 (60%) 1 (100%) 8 (80%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 92013-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY 4-METHYLIMIDAZOLE Date: 08/06/96
Route: DOSED FEED Time: 20:49:10
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE UNTREAT 625 1250 2500 5000 10000
CONTROL PPM PPM PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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