TDMS Study 93021-04 Pathology Tables
NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:18:14
13 WEEK SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 538-75-0
Lock Date: 05/17/95
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:18:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 1.5 3 6.0 12 24.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 10
Survivors
Terminal Sacrifice 10 9 10 10 10
Accidently Killed 1
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10)
Inflammation, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10)
Bilateral, Capsule, Hyperplasia 5 (50%) 7 (70%)
Capsule, Hyperplasia 2 (20%) 2 (20%)
Pituitary Gland (9) (9) (8)
Pars Distalis, Cyst 1 (13%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (8) (7) (5) (9) (7) (10)
Bilateral, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:18:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 1.5 3 6.0 12 24.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Inguinal, Hyperplasia 1 (100%)
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 2 (20%) 2 (20%) 7 (70%) 9 (90%) 5 (50%) 3 (30%)
Thymus (10) (10) (10) (9) (10) (8)
Atrophy 8 (100%)
Thymocyte, Necrosis 1 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Control, Inflammation 1 (10%) 1 (10%)
Control, Inflammation, Chronic Active 1 (10%) 3 (30%) 5 (50%) 5 (50%)
Epidermis, Control, Hyperplasia 3 (30%)
Epidermis, Skin, Site of Application,
Hyperplasia 5 (50%) 9 (90%) 10 (100%) 10 (100%) 3 (30%)
Epidermis, Skin, Site of Application,
Necrosis 2 (20%) 3 (30%) 10 (100%)
Epidermis, Skin, Site of Application,
Necrosis, Focal 1 (10%)
Skin, Site of Application, Inflammation,
Chronic Active 1 (10%) 9 (90%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (10) (10) (10) (10) (10) (10)
Pons, Hemorrhage 6 (60%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:18:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 1.5 3 6.0 12 24.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:18:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 1.5 3 6.0 12 24.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 9
Natural Death 1
Survivors
Terminal Sacrifice 9 9 8 10 10
Accidently Killed 1 1 2
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10)
Inflammation, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (9)
Bilateral, Capsule, Hyperplasia 1 (10%)
Capsule, Hyperplasia 1 (10%) 3 (30%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (9) (10) (10) (10) (10) (10)
Atrophy 1 (10%)
Bilateral, Atrophy 4 (40%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:18:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 1.5 3 6.0 12 24.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 5 (50%) 2 (20%) 7 (70%) 6 (60%) 6 (60%)
Thymus (9) (10) (9) (9) (10) (8)
Atrophy 8 (100%)
Thymocyte, Necrosis 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10) (10) (10)
Hyperplasia 1 (10%)
Control, Inflammation 1 (10%)
Control, Inflammation, Chronic Active 1 (10%) 1 (10%) 1 (10%) 3 (30%)
Epidermis, Control, Hyperplasia 1 (10%)
Epidermis, Control, Necrosis 2 (20%)
Epidermis, Control, Necrosis, Diffuse 1 (10%)
Epidermis, Skin, Site of Application,
Hyperplasia 7 (70%) 10 (100%) 10 (100%) 10 (100%)
Epidermis, Skin, Site of Application,
Necrosis 1 (10%) 2 (20%) 10 (100%)
Epidermis, Skin, Site of Application,
Necrosis, Focal 2 (20%)
Skin, Site of Application, Inflammation,
Chronic Active 4 (40%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (10) (10) (10) (10) (10) (10)
Pons, Hemorrhage 2 (20%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97
Route: SKIN APPLICATION Time: 10:18:14
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 1.5 3 6.0 12 24.0
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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