TDMS Study 93021-04 Pathology Tables
NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:18:14 13 WEEK SUBCHRONIC Facility: Microbiological Associates Chemical CAS #: 538-75-0 Lock Date: 05/17/95 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:18:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 1.5 3 6.0 12 24.0 MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Moribund Sacrifice 10 Survivors Terminal Sacrifice 10 9 10 10 10 Accidently Killed 1 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) Inflammation, Focal 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) Bilateral, Capsule, Hyperplasia 5 (50%) 7 (70%) Capsule, Hyperplasia 2 (20%) 2 (20%) Pituitary Gland (9) (9) (8) Pars Distalis, Cyst 1 (13%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Clitoral Gland (8) (7) (5) (9) (7) (10) Bilateral, Atrophy 1 (10%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:18:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 1.5 3 6.0 12 24.0 MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) Inguinal, Hyperplasia 1 (100%) Spleen (10) (10) (10) (10) (10) (10) Hematopoietic Cell Proliferation 2 (20%) 2 (20%) 7 (70%) 9 (90%) 5 (50%) 3 (30%) Thymus (10) (10) (10) (9) (10) (8) Atrophy 8 (100%) Thymocyte, Necrosis 1 (13%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (10) (10) (10) (10) (10) (10) Control, Inflammation 1 (10%) 1 (10%) Control, Inflammation, Chronic Active 1 (10%) 3 (30%) 5 (50%) 5 (50%) Epidermis, Control, Hyperplasia 3 (30%) Epidermis, Skin, Site of Application, Hyperplasia 5 (50%) 9 (90%) 10 (100%) 10 (100%) 3 (30%) Epidermis, Skin, Site of Application, Necrosis 2 (20%) 3 (30%) 10 (100%) Epidermis, Skin, Site of Application, Necrosis, Focal 1 (10%) Skin, Site of Application, Inflammation, Chronic Active 1 (10%) 9 (90%) 10 (100%) 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (10) (10) (10) (10) (10) (10) Pons, Hemorrhage 6 (60%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:18:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE FEMALE 0 1.5 3 6.0 12 24.0 MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:18:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 1.5 3 6.0 12 24.0 MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 10 10 Early Deaths Moribund Sacrifice 9 Natural Death 1 Survivors Terminal Sacrifice 9 9 8 10 10 Accidently Killed 1 1 2 Animals Examined Microscopically 10 10 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) Inflammation, Focal 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (9) Bilateral, Capsule, Hyperplasia 1 (10%) Capsule, Hyperplasia 1 (10%) 3 (30%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Preputial Gland (9) (10) (10) (10) (10) (10) Atrophy 1 (10%) Bilateral, Atrophy 4 (40%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:18:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 1.5 3 6.0 12 24.0 MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (10) (10) (10) (10) (10) (10) Hematopoietic Cell Proliferation 5 (50%) 2 (20%) 7 (70%) 6 (60%) 6 (60%) Thymus (9) (10) (9) (9) (10) (8) Atrophy 8 (100%) Thymocyte, Necrosis 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (10) (10) (10) (10) (10) (10) Hyperplasia 1 (10%) Control, Inflammation 1 (10%) Control, Inflammation, Chronic Active 1 (10%) 1 (10%) 1 (10%) 3 (30%) Epidermis, Control, Hyperplasia 1 (10%) Epidermis, Control, Necrosis 2 (20%) Epidermis, Control, Necrosis, Diffuse 1 (10%) Epidermis, Skin, Site of Application, Hyperplasia 7 (70%) 10 (100%) 10 (100%) 10 (100%) Epidermis, Skin, Site of Application, Necrosis 1 (10%) 2 (20%) 10 (100%) Epidermis, Skin, Site of Application, Necrosis, Focal 2 (20%) Skin, Site of Application, Inflammation, Chronic Active 4 (40%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (10) (10) (10) (10) (10) (10) Pons, Hemorrhage 2 (20%) ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 93021-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 90-DAY DICYCLOHEXYLCARBODIIMIDE Date: 09/02/97 Route: SKIN APPLICATION Time: 10:18:14 ____________________________________________________________________________________________________________________________________ B6C3F1 MICE MALE 0 1.5 3 6.0 12 24.0 MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------