TDMS Study 96010-03 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) DATE: 05/28/03
EXPERIMENT: 96010 TEST: 03 TIME: 10:17:28
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: C96010A
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1/RATS
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: SOUTHERN RESEARCH INSTITUTE WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE) DATE: 05/28/03
EXPERIMENT: 96010 TEST: 03 TIME: 10:25:48
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP: 96010A
CONT: N01-ES-85420 CAS: 7775-09-9
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
==================================================================================================================================
0 MG/L 125 MG/L 1000MG/L 2000MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 15.9 187.3 16.8 187.1 1.06 11.3 16.2 184.9 1.02 87.5 17.1 185.9 1.08 183.5
8 16.4 261.0 16.3 262.5 0.99 7.8 17.2 265.5 1.05 64.7 17.5 270.1 1.07 129.3
12 16.0 312.2 15.9 315.4 0.99 6.3 16.5 319.3 1.03 51.7 16.6 322.2 1.04 103.2
16 15.6 347.6 14.6 351.1 0.94 5.2 15.5 356.8 0.99 43.5 15.3 358.0 0.98 85.6
20 15.3 373.1 15.5 374.3 1.01 5.2 15.6 378.9 1.02 41.2 15.8 381.7 1.03 83.0
24 14.8 392.5 14.7 395.7 0.99 4.6 15.3 401.8 1.03 38.1 15.8 402.7 1.07 78.4
28 15.3 420.0 15.6 422.9 1.02 4.6 16.3 428.6 1.07 37.9 17.4 427.6 1.14 81.3
32 14.1 436.5 14.2 439.1 1.01 4.1 14.3 444.8 1.01 32.2 14.7 445.6 1.04 66.2
36 13.5 441.8 13.4 444.6 0.99 3.8 13.2 451.9 0.98 29.3 14.1 450.7 1.04 62.5
40 14.3 459.4 14.8 461.2 1.03 4.0 14.4 466.4 1.01 30.9 14.6 468.0 1.02 62.4
44 13.2 467.1 14.4 473.7 1.09 3.8 14.4 476.5 1.09 30.3 14.6 478.3 1.11 61.2
48 13.3 474.7 13.7 478.8 1.03 3.6 13.8 481.7 1.04 28.7 13.8 485.6 1.04 56.7
52 13.4 487.3 13.8 490.9 1.03 3.5 13.5 493.2 1.01 27.4 13.8 494.0 1.03 55.7
56 14.2 489.2 14.7 493.2 1.04 3.7 14.7 497.0 1.04 29.6 15.1 498.1 1.06 60.8
60 15.0 494.9 15.2 499.3 1.01 3.8 15.4 501.1 1.03 30.7 15.6 501.3 1.04 62.1
64 15.2 498.9 15.1 503.1 0.99 3.8 15.2 505.1 1.00 30.1 15.7 504.6 1.03 62.1
68 14.8 500.4 15.0 502.7 1.01 3.7 15.1 504.2 1.02 30.0 15.5 504.9 1.05 61.2
72 14.7 496.7 15.4 501.8 1.05 3.8 15.8 505.8 1.07 31.3 15.5 504.1 1.05 61.5
76 15.4 508.1 15.6 505.8 1.01 3.9 16.1 508.3 1.05 31.7 16.1 509.4 1.05 63.3
80 14.6 507.8 14.4 505.8 0.99 3.6 14.8 507.3 1.01 29.1 15.6 507.5 1.07 61.4
84 15.2 512.2 15.6 507.5 1.03 3.8 16.1 512.7 1.06 31.4 16.7 509.6 1.10 65.6
88 15.7 508.9 15.7 501.3 1.00 3.9 15.8 516.0 1.01 30.6 17.2 509.5 1.10 67.5
92 14.8 514.1 15.8 501.1 1.07 3.9 15.1 513.6 1.02 29.4 16.2 507.8 1.09 63.9
96 14.9 507.3 14.9 499.9 1.00 3.7 15.2 504.6 1.02 30.1 15.7 497.5 1.05 63.0
100 14.1 496.5 14.7 486.1 1.04 3.8 15.5 503.5 1.10 30.7 16.4 488.4 1.16 67.2
104 15.0 489.6 16.5 496.5 1.10 4.2 15.7 499.7 1.05 31.4 17.2 495.6 1.15 69.3
1 TO 13 WEEKS
----------------
MEAN 16.1 253.5 16.4 255.0 1.01 8.4 16.6 256.5 1.03 68.0 17.0 259.4 1.06 138.7
SD(D) 0.3 0.5 0.04 2.5 0.5 0.02 18.2 0.4 0.02 40.9
CV(E) 1.7 2.8 3.6 30.1 3.1 1.5 26.7 2.5 1.9 29.5
14 TO 52 WEEKS
----------------
MEAN 14.3 430.0 14.5 433.2 1.01 4.2 14.6 438.1 1.02 34.0 15.0 439.2 1.05 69.3
SD(D) 0.9 0.7 0.04 0.6 1.0 0.03 5.7 1.1 0.04 11.5
CV(E) 6.4 5.1 3.9 14.9 6.8 3.3 16.9 7.5 4.2 16.6
> 52 WEEKS
----------------
MEAN 14.9 501.9 15.3 500.3 1.03 3.8 15.4 506.1 1.04 30.5 16.0 503.0 1.08 63.8
SD(D) 0.4 0.6 0.03 0.1 0.5 0.03 0.8 0.7 0.04 2.8
CV(E) 3.0 3.7 3.1 3.7 3.0 2.8 2.7 4.2 3.8 4.4
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
==================================================================================================================================
0 MG/L 125 MG/L 1000MG/L 2000MG/L
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
4 12.7 139.6 12.9 140.9 1.02 11.5 12.8 139.7 1.01 91.8 12.6 137.5 0.99 182.8
8 12.2 168.7 12.5 171.1 1.02 9.1 12.6 169.6 1.03 74.2 12.8 169.1 1.05 151.6
12 11.5 185.5 12.0 186.7 1.04 8.0 11.8 187.7 1.03 62.6 11.6 185.5 1.01 124.8
16 11.1 197.0 11.3 199.7 1.02 7.1 11.1 199.3 1.00 55.6 10.6 196.3 0.95 107.7
20 10.6 204.9 11.3 207.7 1.07 6.8 10.9 207.7 1.03 52.6 10.9 204.4 1.03 106.6
24 10.8 212.9 11.1 215.4 1.03 6.4 10.8 215.7 1.00 50.3 11.3 212.3 1.05 106.3
28 11.5 227.8 11.7 230.4 1.02 6.3 11.7 232.2 1.02 50.5 11.9 226.2 1.03 105.6
32 10.5 231.9 11.1 235.6 1.06 5.9 10.9 236.9 1.04 45.9 11.0 231.2 1.05 94.8
36 10.1 235.4 10.4 238.5 1.03 5.5 9.7 240.0 0.96 40.5 10.1 235.8 1.00 86.0
40 10.7 246.0 10.9 250.4 1.02 5.4 10.8 248.3 1.01 43.4 10.9 243.8 1.02 89.4
44 10.1 258.9 10.9 267.6 1.08 5.1 10.5 264.7 1.04 39.8 11.0 258.9 1.09 84.6
48 10.4 260.4 10.6 265.7 1.02 5.0 10.3 262.8 0.99 39.3 10.4 259.4 1.00 80.4
52 10.5 271.1 11.3 277.1 1.08 5.1 10.3 276.1 0.98 37.2 10.5 266.8 1.00 79.1
56 11.1 278.3 11.5 282.5 1.04 5.1 11.9 283.6 1.07 41.8 11.7 276.2 1.05 85.0
60 11.3 285.4 12.0 287.1 1.06 5.2 12.6 292.6 1.12 43.1 12.8 282.7 1.13 90.3
64 11.9 294.2 12.3 300.5 1.03 5.1 12.5 303.6 1.05 41.2 12.7 290.9 1.07 87.2
68 11.8 303.9 12.1 309.8 1.03 4.9 12.0 308.9 1.02 38.9 12.4 298.3 1.05 83.3
72 12.1 308.2 12.4 313.2 1.02 4.9 12.8 315.6 1.06 40.5 12.7 305.1 1.05 83.2
76 12.8 322.4 13.2 324.6 1.03 5.1 12.8 327.8 1.00 39.1 13.3 317.3 1.04 83.8
80 12.4 327.1 11.8 330.6 0.95 4.5 12.0 332.2 0.97 36.1 12.4 323.4 1.00 76.6
84 12.9 331.3 13.1 337.1 1.02 4.8 13.2 336.8 1.02 39.1 13.7 329.5 1.06 83.0
88 13.4 336.6 13.6 338.3 1.01 5.0 13.7 340.9 1.02 40.1 13.7 330.6 1.02 83.2
92 13.2 340.1 12.4 342.4 0.94 4.5 13.4 345.2 1.02 38.9 13.5 338.5 1.02 79.5
96 13.8 340.0 14.0 342.5 1.01 5.1 13.5 352.0 0.98 38.5 14.2 332.3 1.03 85.5
100 13.5 341.7 13.4 350.3 0.99 4.8 13.9 351.3 1.03 39.5 14.5 336.7 1.07 86.0
104 13.4 338.7 13.1 351.0 0.98 4.7 14.7 358.7 1.10 41.0 14.1 341.1 1.05 82.5
1 TO 13 WEEKS
----------------
MEAN 12.1 164.6 12.5 166.3 1.03 9.5 12.4 165.7 1.02 76.2 12.3 164.0 1.02 153.0
SD(D) 0.6 0.5 0.01 1.8 0.6 0.01 14.7 0.7 0.03 29.0
CV(E) 5.0 3.8 1.4 18.5 4.6 1.3 19.3 5.4 2.9 19.0
14 TO 52 WEEKS
----------------
MEAN 10.6 234.6 11.0 238.8 1.04 5.9 10.7 238.4 1.01 45.5 10.9 233.5 1.02 94.0
SD(D) 0.4 0.4 0.03 0.8 0.5 0.03 6.4 0.5 0.04 11.6
CV(E) 4.1 3.4 2.5 13.1 5.1 2.5 14.1 4.6 3.6 12.4
> 52 WEEKS
----------------
MEAN 12.6 319.1 12.7 323.8 1.01 4.9 13.0 326.9 1.03 39.8 13.2 315.6 1.05 83.8
SD(D) 0.9 0.8 0.03 0.2 0.8 0.04 1.8 0.8 0.03 3.4
CV(E) 7.0 6.0 3.5 4.9 6.4 4.2 4.4 6.2 3.1 4.0
==================================================================================================================================
(A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY MALE RATS IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
=========================================================================================================
0 MG/L 125 MG/L 1000MG/L 2000MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 102.1 50 103.0 50 102.9 50 102.7 50
1 102.1 50 103.0 50 102.9 50 102.7 50
4 15.9 8357 187.3 50 16.8 8180 187.1 50 16.2 8266 184.9 50 17.1 8192 185.9 50
8 16.4 8243 261.0 50 16.3 8185 262.5 50 17.2 8292 265.5 50 17.5 8195 270.1 50
12 16.0 8390 312.2 50 15.9 8378 315.4 50 16.5 8290 319.3 50 16.6 8370 322.2 50
16 15.6 8204 347.6 50 14.6 8295 351.1 50 15.5 8083 356.8 50 15.3 8436 358.0 50
20 15.3 8276 373.1 50 15.5 8382 374.3 50 15.6 8131 378.9 50 15.8 8007 381.7 50
24 14.8 8009 392.5 50 14.7 7961 395.7 50 15.3 8119 401.8 50 15.8 7160 402.7 50
28 15.3 8303 420.0 50 15.6 8116 422.9 50 16.3 8236 428.6 50 17.4 7675 427.6 50
32 14.1 8253 436.5 50 14.2 8153 439.1 50 14.3 8084 444.8 49 14.7 8404 445.6 50
36 13.5 8612 441.8 50 13.4 8602 444.6 50 13.2 8395 451.9 49 14.1 8565 450.7 50
40 14.3 7744 459.4 50 14.8 7895 461.2 50 14.4 8105 466.4 49 14.6 8201 468.0 50
44 13.2 8578 467.1 50 14.4 8277 473.7 50 14.4 8147 476.5 49 14.6 8157 478.3 50
48 13.3 8334 474.7 50 13.7 8250 478.8 50 13.8 8076 481.7 49 13.8 8029 485.6 50
52 13.4 8327 487.3 50 13.8 8172 490.9 50 13.5 8241 493.2 49 13.8 8400 494.0 50
56 14.2 8124 489.2 49 14.7 8284 493.2 50 14.7 8119 497.0 49 15.1 8182 498.1 50
60 15.0 7917 494.9 49 15.2 8188 499.3 50 15.4 7971 501.1 49 15.6 7910 501.3 50
64 15.2 7904 498.9 48 15.1 8267 503.1 50 15.2 7959 505.1 49 15.7 7824 504.6 50
68 14.8 7775 500.4 47 15.0 8267 502.7 50 15.1 8088 504.2 49 15.5 7990 504.9 48
72 14.7 7530 496.7 47 15.4 8387 501.8 50 15.8 8026 505.8 48 15.5 7372 504.1 47
76 15.4 7424 508.1 45 15.6 8292 505.8 50 16.1 7698 508.3 48 16.1 7555 509.4 47
80 14.6 6810 507.8 44 14.4 7950 505.8 49 14.8 7874 507.3 48 15.6 7640 507.5 46
84 15.2 6501 512.2 43 15.6 6966 507.5 45 16.1 7370 512.7 45 16.7 7415 509.6 45
88 15.7 6688 508.9 43 15.7 7115 501.3 44 15.8 6984 516.0 43 17.2 6894 509.5 44
92 14.8 6220 514.1 39 15.8 6336 501.1 41 15.1 6950 513.6 42 16.2 6668 507.8 43
96 14.9 6698 507.3 40 14.9 6291 499.9 38 15.2 6348 504.6 40 15.7 6783 497.5 40
100 14.1 5914 496.5 40 14.7 5517 486.1 35 15.5 5448 503.5 37 16.4 5895 488.4 36
104 15.0 5518 489.6 36 16.5 4571 496.5 28 15.7 5085 499.7 31 17.2 4358 495.6 28
MEAN BODY WGT FOR WEEKS
1 TO 13 215.7 217.0 218.1 220.2
14 TO 52 430.0 433.2 438.1 439.2
> 52 501.9 500.3 506.1 503.0
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
WATER AND COMPOUND CONSUMPTION BY FEMALE RATS IN THE
CHRONIC DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (SODIUM CHLORATE)
=========================================================================================================
0 MG/L 125 MG/L 1000MG/L 2000MG/L
---------------------- ---------------------- ---------------------- ----------------------
DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM
WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS
==========================================================================================================
B 91.3 50 90.7 50 91.0 50 89.1 50
1 91.3 50 90.7 50 91.0 50 89.1 50
4 12.7 8260 139.6 50 12.9 8262 140.9 50 12.8 8247 139.7 50 12.6 8290 137.5 50
8 12.2 7720 168.7 50 12.5 8410 171.1 50 12.6 8288 169.6 50 12.8 8266 169.1 50
12 11.5 8385 185.5 50 12.0 8351 186.7 50 11.8 8375 187.7 50 11.6 7908 185.5 50
16 11.1 8103 197.0 50 11.3 8423 199.7 50 11.1 8410 199.3 50 10.6 8053 196.3 50
20 10.6 7955 204.9 50 11.3 8281 207.7 50 10.9 8402 207.7 50 10.9 8424 204.4 50
24 10.8 7434 212.9 50 11.1 8043 215.4 50 10.8 7964 215.7 50 11.3 8129 212.3 50
28 11.5 8375 227.8 50 11.7 7472 230.4 50 11.7 8240 232.2 50 11.9 8037 226.2 50
32 10.5 7959 231.9 50 11.1 8425 235.6 50 10.9 7612 236.9 50 11.0 8122 231.2 50
36 10.1 8647 235.4 50 10.4 8605 238.5 50 9.7 8575 240.0 50 10.1 8570 235.8 50
40 10.7 8265 246.0 50 10.9 8250 250.4 50 10.8 8274 248.3 50 10.9 8255 243.8 50
44 10.1 8293 258.9 50 10.9 8273 267.6 50 10.5 8325 264.7 50 11.0 8233 258.9 50
48 10.4 8351 260.4 50 10.6 8255 265.7 50 10.3 8241 262.8 50 10.4 8240 259.4 50
52 10.5 7627 271.1 50 11.3 7784 277.1 50 10.3 8415 276.1 50 10.5 8410 266.8 50
56 11.1 8300 278.3 50 11.5 8004 282.5 49 11.9 8029 283.6 50 11.7 8300 276.2 50
60 11.3 7795 285.4 50 12.0 8089 287.1 49 12.6 7973 292.6 49 12.8 7753 282.7 50
64 11.9 8070 294.2 49 12.3 7769 300.5 47 12.5 8100 303.6 49 12.7 8299 290.9 50
68 11.8 7949 303.9 48 12.1 7782 309.8 47 12.0 8117 308.9 49 12.4 8304 298.3 50
72 12.1 7664 308.2 48 12.4 7563 313.2 47 12.8 8206 315.6 49 12.7 8207 305.1 49
76 12.8 7477 322.4 47 13.2 6802 324.6 46 12.8 7404 327.8 47 13.3 8109 317.3 49
80 12.4 7623 327.1 46 11.8 7568 330.6 45 12.0 7138 332.2 46 12.4 7583 323.4 48
84 12.9 7535 331.3 45 13.1 7265 337.1 44 13.2 6865 336.8 45 13.7 7443 329.5 48
88 13.4 6742 336.6 43 13.6 6937 338.3 44 13.7 6816 340.9 43 13.7 6829 330.6 48
92 13.2 6914 340.1 42 12.4 6733 342.4 40 13.4 6107 345.2 38 13.5 6767 338.5 46
96 13.8 6696 340.0 40 14.0 6020 342.5 38 13.5 6296 352.0 37 14.2 7526 332.3 45
100 13.5 6434 341.7 40 13.4 6332 350.3 38 13.9 5696 351.3 37 14.5 6064 336.7 42
104 13.4 6336 338.7 38 13.1 6307 351.0 37 14.7 5476 358.7 33 14.1 5917 341.1 41
MEAN BODY WGT FOR WEEKS
1 TO 13 146.3 147.4 147.0 145.3
14 TO 52 234.6 238.8 238.4 233.5
> 52 319.1 323.8 326.9 315.6
=========================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
--multipart-boundary
Content-type: text/plain
Range: bytes 32556-32556/32556
--multipart-boundary--