TDMS Study 92013-05 Pathology Tables
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
FINAL #1 RATS
Facility: Southern Research Institute
Chemical CAS #: 822-36-6
Lock Date: 09/13/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + A +|
Edema | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A A + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A A + + A M|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X |
Congestion | |
Degeneration, Cystic, Focal | 1 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3|
Hepatodiaphragmatic Nodule | X X X |
Histiocytosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic | 1 2 1 1 1 1 |
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X X |
Bile Duct, Hyperplasia | 1 2 2 1 1 1 2 1 1 2 2 1 2 1 1|
Hepatocyte, Fatty Change, Focal | 1 1 1 1 2 1 |
Hepatocyte, Hyperplasia, Focal | 3 |
Hepatocyte, Necrosis, Focal | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 4 2|
Hepatocyte, Centrilobular, Necrosis | 3 |
Oval Cell, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Chronic | 3 |
Fat, Necrosis, Focal | 3 2 2 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +|
Acinus, Atrophy, Diffuse | 4 |
Acinus, Atrophy, Focal | 1 1 2 1 2 1 2 |
Duct, Cyst, Focal, Multiple | 2 1 2 1 2 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 2 |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 1 1 1 1 1 1 1 1 2 2|
Epicardium, Inflammation | 3 |
Myocardium, Fibrosis, Focal | |
Pericardium, Infiltration Cellular, | |
Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + A + + + +|
Accessory Adrenal Cortical Nodule | 2 1 1 |
Angiectasis | 3 3 |
Cytoplasmic Alteration, Focal | 2 |
Vacuolization Cytoplasmic, Focal | 2 3 |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + A + + + +|
Angiectasis | |
Hyperplasia, Focal | 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Degeneration, Cystic, | |
Focal | 1 3 2 1 2 |
Pars Distalis, Hyperplasia, Focal | 2 3 |
Pars Distalis, Hypertrophy, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A A + + A +|
C-Cell, Hyperplasia | 2 2 4 2 2 2 2 3 2 2 4 2 2 2 1 2 2 3 1 2 3|
Follicle, Mineralization | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + +|
Fibrosis, Focal | |
Mediastinum, Cyst | 2|
Mediastinum, Infiltration Cellular, | |
Mixed Cell | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 3 |
Hyperplasia, Cystic | 3 2 2 |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Cyst | X X X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Granulomatous | 3 |
Cervix, Hypertrophy | 3 |
Endometrium, Hyperplasia, Cystic | 1 1 1 2 1 3 2 2 1|
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + A + + + +|
Deep Cervical, Hemorrhage | 3|
Mediastinal, Ectasia | 4 3 3 |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 3 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Pigmentation | |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 |
Pancreatic, Hyperplasia, Plasma Cell | 3 |
Pancreatic, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A + + + +|
Hyperplasia, Histiocytic | 3 3 3 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 3 3 3|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + I + I + + + I|
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 4 |
Epithelial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 2 3 4 4 2 3 2 3 4 4 2 2 2 2 2 3 3 2 2 3 2|
Fibrosis | 3 |
Hyperplasia | 2 3 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 1 3 3 |
Hemorrhage, Focal | 2 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | |
Infiltration Cellular, Mixed Cell | 1 2 2|
Inflammation, Chronic, Focal | 1 1 1 1 1 1 1 1 1 1 2 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 2 |
Interstitium, Edema | |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 3| 3| 3| 3|
| 7| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 5| 4| 4| 4| 7| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Mediastinum, Edema | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + A + + + + +|
Nasolacrimal Duct, Inflammation | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + A A + + + +|
Cataract | 2 |
Synechia | 3 |
Retina, Degeneration | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | |
Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + A +|
Infarct | |
Nephropathy | 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Dilatation | 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +|
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3| |
| 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Edema | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 46 |
Clear Cell Focus | X X X X X X X X X X X X| 20 |
Congestion | 3 3 | 2 3.0|
Degeneration, Cystic, Focal | | 1 1.0|
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hepatodiaphragmatic Nodule | X X | 5 |
Histiocytosis | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 40 1.0|
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 | 5 1.0|
Inflammation, Chronic | 2 2 1 1 1 1 1 1 1 1 1| 17 1.2|
Inflammation, Granulomatous | | 1 1.0|
Mixed Cell Focus | X X X X X X X X| 10 |
Bile Duct, Hyperplasia | 2 2 2 1 1 2 2 2 1 2 1 1 2 1 2 1| 31 1.5|
Hepatocyte, Fatty Change, Focal | 1 1 1 1 1 1 2 1 2 1| 16 1.2|
Hepatocyte, Hyperplasia, Focal | | 1 3.0|
Hepatocyte, Necrosis, Focal | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 | 6 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3| |
| 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Centrilobular, Necrosis | 3 | 2 3.0|
Oval Cell, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 9 |
Inflammation, Chronic | | 1 3.0|
Fat, Necrosis, Focal | 3 3 2 | 8 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Diffuse | | 1 4.0|
Acinus, Atrophy, Focal | 1 1 1 2 1 1 | 13 1.3|
Duct, Cyst, Focal, Multiple | 2 1 1 2 | 10 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Ulcer | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 2 2.0|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 1 2 1 1 2 1 1 2 2 1 1 1| 30 1.3|
Epicardium, Inflammation | | 1 3.0|
Myocardium, Fibrosis, Focal | 2 | 1 2.0|
Pericardium, Infiltration Cellular, | | |
Mixed Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3| |
| 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 1 1 1 1 2| 8 1.3|
Angiectasis | 2 2| 4 2.5|
Cytoplasmic Alteration, Focal | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 2 4 2 | 8 2.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + M + + + + + + +| 48 |
Angiectasis | 2 | 1 2.0|
Hyperplasia, Focal | | 2 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + + +| 48 |
Angiectasis | 3 3 2 3 3 | 6 2.8|
Pars Distalis, Angiectasis | | 1 3.0|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 3 2 2 1 | 9 1.9|
Pars Distalis, Hyperplasia, Focal | 1 1 | 4 1.8|
Pars Distalis, Hypertrophy, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
C-Cell, Hyperplasia | 1 2 2 1 1 2 1 2 2 1 1 2 2 2 1 4 1 3 1 2 2 2 1 2| 45 2.0|
Follicle, Mineralization | 1 1 | 2 1.0|
Follicular Cell, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + | 5 |
Fibrosis, Focal | 2 | 1 2.0|
Mediastinum, Cyst | | 1 2.0|
Mediastinum, Infiltration Cellular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3| |
| 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
Mixed Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 | 4 2.3|
Hyperplasia, Cystic | 3 2 2 3 | 7 2.4|
Inflammation, Chronic | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 7 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Granulomatous | | 1 3.0|
Cervix, Hypertrophy | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 2 1 2 2 1 1 1 1 2 1 1 2 2 1| 25 1.5|
|__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 3 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 24 |
Deep Cervical, Hemorrhage | 3 3 | 3 3.0|
Mediastinal, Ectasia | | 3 3.3|
Mediastinal, Hemorrhage | 3 3 3 | 5 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3| 4 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Pigmentation | 3 | 1 3.0|
Pancreatic, Hemorrhage | 2 | 1 2.0|
Pancreatic, Hyperplasia, Histiocytic | 3 3 2 | 6 2.8|
Pancreatic, Hyperplasia, Plasma Cell | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3| |
| 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pancreatic, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Histiocytic | 3 3 | 7 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 3 |
Fibrosis, Focal | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 3 | 6 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | 3 2 | 2 2.5|
Hyperplasia, Lymphoid | | 1 4.0|
Epithelial Cell, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 2 3 3 2 2 2 3 3 4 2 4 3 2 2| 37 2.7|
Fibrosis | | 1 3.0|
Hyperplasia | 2 3 2 | 6 2.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3| |
| 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 3 3 2 4 3 3| 13 2.8|
Hemorrhage, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 7 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Hemorrhage, Focal | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | | 3 1.7|
Inflammation, Chronic, Focal | 1 1 1 2 1 1 1 1 1 1 1 1 1| 25 1.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 4 2.0|
Interstitium, Edema | 2 | 1 2.0|
Mediastinum, Edema | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Nasolacrimal Duct, Inflammation | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cataract | 3 3 3 | 4 2.8|
Synechia | | 1 3.0|
Retina, Degeneration | 3 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Histiocytic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 4| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 0| 1| 3| 3| 9| 3| 3| |
| 6| 6| 6| 6| 6| 0| 7| 7| 7| 7| 7| 2| 6| 6| 6| 7| 7| 7| 0| 6| 5| 5| 8| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infarct | 2 | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1| 45 1.1|
Pelvis, Dilatation | | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 4 2| 3 2.7|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X X X X X|
Congestion | 2 |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X |
Histiocytosis | 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 2 2 1|
Infiltration Cellular, Mixed Cell | 1 1 1 |
Inflammation, Chronic | 1 1 1 2 1 1 1 1 2 2 1 3 1 |
Mixed Cell Focus | X X X X |
Bile Duct, Hyperplasia | 1 1 1 1 2 2 1 2 1 2 2 2 3 2 1 1 1 1 1 2 2|
Hepatocyte, Fatty Change, Focal | 1 1 1 1 2 2 1 2 2 1 2 1|
Hepatocyte, Vacuolization Cytoplasmic| 3 1 2 2 2 3 2 |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis, Focal | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +|
Acinus, Atrophy, Focal | 2 1 1 1 2 2 2|
Duct, Cyst, Focal, Multiple | 2 2 1 2 2 2 2 3 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 4 |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Ulcer | |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Tooth | |
Malformation | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 1 2 2 1 1 2 1 1 1 1 2 1 2 1 2 1|
Inflammation, Focal, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 |
Angiectasis | 2 3 |
Cytoplasmic Alteration, Focal | 1 |
Hematopoietic Cell Proliferation | |
Vacuolization Cytoplasmic, Focal | 2 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 2 |
Cyst | X X |
Hyperplasia, Focal, Histiocytic | |
Pars Distalis, Angiectasis | |
Pars Distalis, Degeneration, Cystic, | |
Focal | 2 1 |
Pars Distalis, Hyperplasia, Focal | 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + A A + + + + + + + + + + + + A + + + + +|
C-Cell, Hyperplasia | 1 2 2 1 1 1 1 2 2 1 1 2 3 2 2 2 1 3 3 1 2|
Follicle, Cyst | X |
Follicle, Mineralization | 1 1 1 1|
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 3 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 3 1 2 1 1 2 2 1 3 3 3 2 1 2 1|
|__________________________________________________________________________|
Vagina | |
Infiltration Cellular, | |
Polymorphonuclear | |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + A + + + + +|
Fibrosis | |
Hyperplasia, Focal, Histiocytic | 2 |
Hyperplasia | |
Erythroid Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Lymph Node | + + + |
Mediastinal, Congestion | |
Mediastinal, Ectasia | 3 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Histiocytic| |
Pancreatic, Hyperplasia, Histiocytic | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M + M M M M M M M M M M M M M M M|
Ectasia | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Spleen | + + + M + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 |
Inflammation, Granulomatous | |
Stromal Hyperplasia | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Dilatation | 2 3 4 2 2 3 2 |
Hyperplasia | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Pinna, Inflammation, Chronic, Focal | |
Subcutaneous Tissue, Edema | 2 |
Subcutaneous Tissue, Fibrosis, Focal | |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 |
Hemorrhage, Focal | 3 |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 1 2 |
Hyperplasia, Focal, Histiocytic | |
Infiltration Cellular, Mixed Cell | 1 |
Inflammation, Chronic, Focal | 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 |
Mediastinum, Edema | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Inflammation, Suppurative | 1 |
Nasolacrimal Duct, Inflammation | 1 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + A A + + + + + + + A + + + + + + + + + +|
Inflammation, Chronic | |
Anterior Chamber, Exudate | 3 |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 4| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 1| 2| 6| 5| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 6| 6| 6| 6| 2| 1| 3| 3| 6| 6| 7| 7| 7| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Cornea, Inflammation, Chronic | |
Cornea, Necrosis, Focal | |
Retina, Degeneration | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | 2 1 |
Inflammation | 1 |
|__________________________________________________________________________|
Zymbal's Gland | + + |
Cyst | 4 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +|
Infarct | |
Mineralization, Focal | |
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 20
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3| |
| 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + A + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + A + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + A + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 43 |
Clear Cell Focus | X X X X X X X X X X X X X X X X| 32 |
Congestion | 3 | 2 2.5|
Eosinophilic Focus | X | 2 |
Hepatodiaphragmatic Nodule | X X X | 4 |
Histiocytosis | 1 2 2 1 1 2 2 1 2 1 1 2 2 2 1 1 1 1 1 2 2 1 1 1 1| 50 1.3|
Infiltration Cellular, Mixed Cell | 2 2 | 5 1.4|
Inflammation, Chronic | 1 1 1 1 2 2 1 1 1 4 2 1 3 1 1 | 28 1.5|
Mixed Cell Focus | X X X | 7 |
Bile Duct, Hyperplasia | 2 2 1 2 3 2 1 1 2 1 2 2 2 2 1 2 2| 38 1.6|
Hepatocyte, Fatty Change, Focal | 1 2 1 1 2 1 2 2 3 3 2 2 2 1 1 1 2| 29 1.6|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 2 2 2 | 12 2.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 7 |
Fat, Necrosis, Focal | 2 1 3 | 3 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | 3 2 1 1 3 2 2 2 1 1 2 2 1 2 1| 22 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3| |
| 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Duct, Cyst, Focal, Multiple | 2 2 3 2 1 2 1 2 3| 18 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + + + + | 5 |
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Malformation | 2 | 1 2.0|
Peridontal Tissue, Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 1 2 1 3 1 2 2 2 2 2 2 2 2 1 2 1 1 1 1 2 1| 43 1.5|
Inflammation, Focal, Suppurative | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 2 1 | 6 1.2|
Angiectasis | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3| |
| 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Cytoplasmic Alteration, Focal | 1 | 2 1.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Vacuolization Cytoplasmic, Focal | 2 1 2 3 3 | 9 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 4 2.3|
Cyst | X X | 4 |
Hyperplasia, Focal, Histiocytic | 2 | 1 2.0|
Pars Distalis, Angiectasis | 1 1| 2 1.0|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 2 3 3 4 | 6 2.5|
Pars Distalis, Hyperplasia, Focal | 2 3 2 | 4 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + I + + + + + A + + + + + + + + A + + + + + + + +| 44 |
C-Cell, Hyperplasia | 1 1 2 1 1 2 2 1 1 1 2 2 1 2 2 2 2 1 2 4 2| 42 1.7|
Follicle, Cyst | | 1 |
Follicle, Mineralization | 1 1 1 | 7 1.0|
Follicular Cell, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Cystic | 2 2 | 4 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3| |
| 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic | 1 2| 2 1.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 3 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 1 2 1 1 2 3 2 2 2 3 | 26 1.9|
|__________________________________________________________________________|____________|
Vagina | + + | 2 |
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Fibrosis | 3 | 1 3.0|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
Hyperplasia | 3 3 | 2 3.0|
Erythroid Cell, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 11 |
Mediastinal, Congestion | 3 | 1 3.0|
Mediastinal, Ectasia | | 1 3.0|
Mediastinal, Hemorrhage | 3 2 | 3 2.7|
Mediastinal, Hyperplasia, Histiocytic| 3 | 1 3.0|
Pancreatic, Hyperplasia, Histiocytic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M + M M M M M M M M M M M + M M M M| 3 |
Ectasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3| |
| 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Inflammation, Granulomatous | 3 2 3 | 3 2.7|
Stromal Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Dilatation | 3 2 2 3 2 2 2 2 1 | 16 2.3|
Hyperplasia | 2 1| 3 1.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 | 1 3.0|
Pinna, Inflammation, Chronic, Focal | 2 | 1 2.0|
Subcutaneous Tissue, Edema | | 1 2.0|
Subcutaneous Tissue, Fibrosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 3 3 3 3 | 8 3.0|
Hemorrhage, Focal | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 3 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3| |
| 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 2 | 5 2.2|
Hyperplasia, Focal, Histiocytic | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 1.0|
Inflammation, Chronic, Focal | 2 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 2| 40 1.2|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 3 1.3|
Mediastinum, Edema | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 2 1.5|
Inflammation, Suppurative | 3 2 | 3 2.0|
Nasolacrimal Duct, Inflammation | 3 2 2 | 5 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + A + + + + + + + + A + + + + + + + +| 45 |
Inflammation, Chronic | 4 | 1 4.0|
Anterior Chamber, Exudate | | 1 3.0|
Cornea, Inflammation, Chronic | 4 | 1 4.0|
Cornea, Necrosis, Focal | 4 | 1 4.0|
Retina, Degeneration | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Histiocytic | 1 2 | 4 1.5|
Inflammation | | 1 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 0| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 5| 3| 3| 3| 3| |
| 4| 6| 6| 6| 6| 6| 6| 7| 0| 6| 7| 7| 7| 7| 7| 6| 5| 6| 6| 6| 7| 6| 6| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Infarct | 2 | 1 2.0|
Mineralization, Focal | 2 | 1 2.0|
Nephropathy | 1 1 1 1 3 1 1 1 1 2 3 1 1 1 1 1 1 1 | 37 1.1|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + A A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + A A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + M + + + + + A A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + A + + + + + A A + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + A + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X X|
Degeneration, Cystic, Focal | 3 |
Eosinophilic Focus | X X X |
Hepatodiaphragmatic Nodule | X X|
Histiocytosis | 2 2 2 2 2 2 2 2 1 2 2 1 2 2 1 3 1 2 3 2 1 1 2 1|
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic | 3 1 2 1 2 2 1 2 2 1 1 1 2 2 1 1 1|
Mixed Cell Focus | X X X X X |
Thrombosis | 2 |
Bile Duct, Dilatation, Focal | 3 |
Bile Duct, Hyperplasia | 2 2 3 1 2 2 1 1 2 2 1 3 2 3 2 2 1 3 3 1 1|
Hepatocyte, Fatty Change, Focal | 2 1 2 3 3 2 2 1 2 2 2 1 3 2 2 3|
Hepatocyte, Vacuolization Cytoplasmic| 4 3 3 2 2 2 1 2 2 |
Hepatocyte, Centrilobular, Necrosis | 3 |
Serosa, Fibrosis | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 3 2 1 2 1 2 1 1 1 3 1|
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Duct, Cyst, Focal, Multiple | 1 1 2 1 2 1|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Edema | 3 |
Inflammation | 1 3 |
Ulcer | 2 |
Epithelium, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
|__________________________________________________________________________|
Tongue | + + + |
Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + I + + + +|
Cardiomyopathy | 2 2 2 2 2 2 1 3 1 2 2 2 2 2 1 1 1|
Thrombosis | 3 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 |
Angiectasis | 3 |
Cytoplasmic Alteration, Focal | 1 |
Hemorrhage, Focal | 3 |
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Vacuolization Cytoplasmic, Focal | 3 2 3 2 1 3 1 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hyperplasia, Focal | 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + A + + + + + + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X |
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Degeneration, Cystic, | |
Focal | 2 |
Pars Distalis, Hemorrhage, Focal | 2 |
Pars Distalis, Hyperplasia, Focal | 1 3 3 |
Pars Distalis, Hypertrophy, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + A + + + + + A + + + + + A A + + + + + + + + + +|
C-Cell, Hyperplasia | 4 2 2 2 2 1 3 2 1 1 2 1 2 1 3 2 2 2 1 2|
Follicle, Degeneration, Focal | |
Follicle, Mineralization | |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 |
Hyperplasia, Cystic | |
Hyperplasia, Focal, Histiocytic | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X|
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
Endometrium, Hyperplasia, Cystic | 1 2 1 3 2 2 1 3 |
|__________________________________________________________________________|
Vagina | + + + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hyperplasia, Focal, Histiocytic | |
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia, Histiocytic | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +|
Accessory Spleen | |
Atrophy | 3 |
Congestion | |
Fibrosis, Focal | 3 |
Inflammation, Granulomatous | 3 3 3 4 |
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Capsule, Infiltration Cellular, | |
Focal, Mixed Cell | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 3 3 |
Hyperplasia | 2 1|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | |
Epidermis, Hyperplasia, Focal | 1 |
Subcutaneous Tissue, Hemorrhage, | |
Focal | |
Subcutaneous Tissue, Necrosis, Fatty,| |
Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 3 3|
Hemorrhage, Focal | 1 3 |
Thalamus, Mineralization, Focal | |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hemorrhage, Focal | 3 3 |
Inflammation, Chronic, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Interstitium, Edema | |
Mediastinum, Congestion | |
Mediastinum, Edema | |
Mediastinum, Mineralization, Focal | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Nasolacrimal Duct, Inflammation | 2 2|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + A + + + + + A + + + + + A A + A + + + + + + + +|
Atrophy | 3 |
Cataract | 2 |
Cornea, Necrosis, Focal | 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 1 |
Hyperplasia, Focal, Histiocytic | 1 1 2 |
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + A + + + + + + + + + +|
Cyst | 2 3 |
Infarct | 4 |
Nephropathy | 1 1 3 1 1 1 1 1 1 1 2 1 1 1 1 3 1 1|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 6| 5| 5| 5| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 7| 5| 8| 7| 3| 3| 3| 3| 3| 3| 3| 3|
| 5| 8| 5| 5| 5| 5| 5| 3| 5| 5| 6| 6| 6| 2| 5| 1| 8| 5| 5| 5| 5| 5| 5| 5| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
2500 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation | |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 34
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3| |
| 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + A + A +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + A + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + A + + + + + + + + + + + + + + + + + A + A +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + A + + + + + + + + + + + + + + + + + A + A +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + A + + + + + + + + + + I + + A + + + A + A +| 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + A + + + + + + + + + + + + + + + + + A + A +| 42 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Basophilic Focus | X X X X X X X X X X X X X X X | 31 |
Clear Cell Focus | X X X X X X X X X X | 23 |
Degeneration, Cystic, Focal | | 1 3.0|
Eosinophilic Focus | X X | 5 |
Hepatodiaphragmatic Nodule | X X X X | 6 |
Histiocytosis | 3 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 3 2| 48 1.9|
Inflammation, Chronic, Focal | | 1 1.0|
Inflammation, Chronic | 1 3 2 1 1 2 1 4 2 3 1 3 3 2 1 1 4| 34 1.8|
Mixed Cell Focus | X | 6 |
Thrombosis | | 1 2.0|
Bile Duct, Dilatation, Focal | 2 | 2 2.5|
Bile Duct, Hyperplasia | 2 2 3 3 2 2 2 1 1 1 2 3 2 2 1 1 1 3 2 2 3 2| 43 1.9|
Hepatocyte, Fatty Change, Focal | 1 3 2 2 3 3 1 1 1 2 1 3 1 | 29 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 4 2 2 3 1 2 3 | 17 2.4|
Hepatocyte, Centrilobular, Necrosis | | 1 3.0|
Serosa, Fibrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + +| 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3| |
| 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation, Chronic | | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + A + A +| 47 |
Acinus, Atrophy, Focal | 1 2 4 3 1 1 1 3 2 2 1 3 1 2 | 26 1.8|
Duct, Cyst, Focal, Multiple | 1 1 2 1 2 | 11 1.4|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | 1 | 2 1.5|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Diverticulum | X | 1 |
Edema | 3 | 2 3.0|
Inflammation | | 2 2.0|
Ulcer | 1 2 | 3 1.7|
Epithelium, Hyperplasia | 2 2 2 | 6 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Erosion | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Tongue | + | 4 |
Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + | 2 |
Malformation | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 2 |
|__________________________________________________________________________|____________|
Heart | A + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cardiomyopathy | 2 2 2 1 2 1 2 2 2 2 1 2 2 2 1 2 2 2 2 2 1| 38 1.8|
Thrombosis | 3 | 2 3.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3| |
| 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 3 1.3|
Angiectasis | 2 3 3 2 2 3 | 7 2.6|
Cytoplasmic Alteration, Focal | 2 | 2 1.5|
Hemorrhage, Focal | 3 | 2 3.0|
Vacuolization Cytoplasmic, Focal | 2 1 1 3 3 | 13 2.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Hyperplasia, Focal | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 2 | 3 2.0|
Cyst | | 2 |
Pars Distalis, Angiectasis | 3 1 | 3 2.0|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 2 1 2 2 | 5 1.8|
Pars Distalis, Hemorrhage, Focal | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 3 2 | 5 2.4|
Pars Distalis, Hypertrophy, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | A + + A + + + + + + A + + + + + + A + + + A + A +| 40 |
C-Cell, Hyperplasia | 2 1 3 2 2 2 1 2 2 1 1 1 2 3 3 2 | 36 1.9|
Follicle, Degeneration, Focal | 1 | 1 1.0|
Follicle, Mineralization | 1 1 1 1 1 1 | 6 1.0|
Follicular Cell, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3| |
| 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + + | 6 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 3 3 | 5 3.0|
Hyperplasia, Cystic | 2 | 1 2.0|
Hyperplasia, Focal, Histiocytic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | A + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Cyst | X X | 5 |
|__________________________________________________________________________|____________|
Oviduct | + | 2 |
|__________________________________________________________________________|____________|
Uterus | A + + + + + + + + + + + + + + + + + + + + + + A +| 48 |
Ulcer | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 3 2 2 1 3 3 1 2 2 | 18 2.1|
|__________________________________________________________________________|____________|
Vagina | + + | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Fibrosis | | 1 3.0|
Hyperplasia, Focal, Histiocytic | 2 2| 2 2.0|
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 24 |
Mediastinal, Hemorrhage | 3 3 3 | 5 3.0|
Mediastinal, Hyperplasia, Histiocytic| | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Pancreatic, Hemorrhage | 2 | 2 2.5|
Pancreatic, Hyperplasia, Histiocytic | 3 3 3| 7 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3| |
| 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M M M M M M M M M M M M M M M M M M M M M M M| 1 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Ectasia | 3 | 2 3.0|
Hyperplasia, Histiocytic | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + A + A +| 47 |
Accessory Spleen | X | 1 |
Atrophy | 2 | 2 2.5|
Congestion | 3 | 1 3.0|
Fibrosis, Focal | | 1 3.0|
Inflammation, Granulomatous | 4 4 2 2 4 3| 10 3.2|
Capsule, Infiltration Cellular, | | |
Focal, Mixed Cell | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + A +| 48 |
Angiectasis | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 1 2 2 2 2 | 8 2.0|
Hyperplasia | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal | 2 | 1 2.0|
Epidermis, Hyperplasia, Focal | | 1 1.0|
Subcutaneous Tissue, Hemorrhage, | | |
Focal | 2 | 1 2.0|
Subcutaneous Tissue, Necrosis, Fatty,| | |
Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3| |
| 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | +| 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 3 3 | 8 3.0|
Hemorrhage, Focal | 1 3 | 4 2.0|
Thalamus, Mineralization, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + | 24 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + | 24 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | +| 1 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 3 3.0|
Hemorrhage, Focal | | 2 3.0|
Inflammation, Chronic, Focal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 39 1.0|
Interstitium, Edema | 2 | 1 2.0|
Mediastinum, Congestion | 3 | 1 3.0|
Mediastinum, Edema | 3 | 1 3.0|
Mediastinum, Mineralization, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 2.0|
Nasolacrimal Duct, Inflammation | 2 2| 4 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 5| 7| 1| 7| |
DAY ON TEST | 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 3| 9| 3| 3| 1| 3| 3| 3| 5| 0| 0| 3| |
| 6| 7| 3| 5| 7| 7| 7| 7| 7| 7| 8| 0| 6| 6| 3| 5| 5| 9| 5| 5| 5| 2| 0| 4| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
2500 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | A + + A + + + + + + A + + + + + + + + + + A + A +| 40 |
Atrophy | 3 4 | 3 3.3|
Cataract | | 1 2.0|
Cornea, Necrosis, Focal | | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cytoplasmic Alteration, Focal | | 1 1.0|
Hyperplasia, Focal, Histiocytic | 1 1| 5 1.2|
Epithelium, Hyperplasia, Focal | 1| 1 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | A + + A + + + + + + + + + + + + + A + + + A + A +| 43 |
Cyst | | 2 2.5|
Infarct | | 1 4.0|
Nephropathy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.1|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +| 49 |
Hemorrhage | | 1 1.0|
Inflammation | 3 | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|
| 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A A + + + + + + + + + + A + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + + + + + + + A A + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A A + + + + + + + + + + A + + + + + + + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X X|
Congestion | 3 |
Degeneration, Cystic, Focal | 2 4 3 |
Eosinophilic Focus | X X X X X X X X |
Hemorrhage | |
Hepatodiaphragmatic Nodule | X X X X X X |
Histiocytosis | 3 4 3 3 2 2 3 3 2 2 2 2 3 2 2 2 2 2 2 2 3 3 3 2 3|
Hyperplasia, Focal, Histiocytic | 2 |
Infiltration Cellular, Mixed Cell | 2 1 1 |
Inflammation, Chronic | 3 2 1 3 2 1 1 2 1 4 2 1 1 1 2 1 2 1 2|
Mixed Cell Focus | X X X X X X X X X X |
Bile Duct, Cyst | X |
Bile Duct, Dilatation, Focal | 2 |
Bile Duct, Hyperplasia | 2 2 2 3 1 2 2 1 1 2 2 2 2 1 |
Hepatocyte, Fatty Change, Focal | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 3|
Hepatocyte, Necrosis, Focal | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 3 |
Hepatocyte, Centrilobular, Necrosis | 4 |
Oval Cell, Hyperplasia, Focal | |
|__________________________________________________________________________|
Mesentery | + + + |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|
| 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis, Focal | |
Lymphatic, Angiectasis | 2 |
|__________________________________________________________________________|
Pancreas | + A A + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 1 2 3 1 2 1 3 2 1 2 2 2 3|
Duct, Cyst, Focal, Multiple | 2 2 1 2 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | 1 |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
|__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 3 2 2 2 2 2 1 3 1 2 2 3 1 2 1 3 2 4 2 2 1|
Thrombosis | 3 3 3 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | 3 |
Cytoplasmic Alteration, Focal | 3 |
Hemorrhage, Focal | |
Vacuolization Cytoplasmic, Focal | 2 2 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|
| 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Angiectasis | |
|__________________________________________________________________________|
Islets, Pancreatic | + A A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 3 |
Cyst | X X X|
Pars Distalis, Degeneration, Cystic, | |
Focal | 1|
Pars Distalis, Hyperplasia, Focal | 3 1 1 |
Pars Distalis, Hypertrophy, Focal | 1 1 |
|__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + A + + + + + + + A + + +|
C-Cell, Hyperplasia | 3 2 2 1 1 1 3 3 1 1 1 1 3 1 1 2|
Follicle, Degeneration, Focal | |
Follicle, Mineralization | 1 1 1 1 1 1 1|
Follicular Cell, Hyperplasia, Focal | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hyperplasia, Cystic | |
Inflammation, Chronic | 2 1 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Periovarian Tissue, Hemorrhage | 3 |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|
| 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 1 2 2 1 2 2 2 1 2 2 1 1 1 |
|__________________________________________________________________________|
Vagina | + |
Angiectasis | |
Infiltration Cellular, | |
Polymorphonuclear | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia, Focal, Histiocytic | 2 2 |
Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node | + + A + + + + + + + + + + + + + + + + |
Hyperplasia, Plasma Cell | |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 3 3 3 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hemorrhage | 3 3 |
Pancreatic, Hyperplasia, Histiocytic | 3 4 3 3 |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Histiocytic | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M M M M + M M M M M M M + M M M M M M M M M M M|
Hyperplasia, Histiocytic | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Histiocytic | 3 3 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + A + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis, Focal | |
Inflammation, Granulomatous | 1 |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|
| 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Capsule, Infiltration Cellular, | |
Focal, Mixed Cell | 1 |
|__________________________________________________________________________|
Thymus | + I + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Epidermis, Hyperplasia, Focal | 3 2 |
Lip, Cyst Epithelial Inclusion | |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 2 |
Hemorrhage, Focal | 2 |
Meninges, Hemorrhage, Focal | 3 |
Thalamus, Mineralization, Focal | 2 |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|
| 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 |
Hemorrhage, Focal | 2 2 |
Hyperplasia, Focal, Histiocytic | 3 |
Infiltration Cellular, Mixed Cell | 3 |
Inflammation, Chronic, Focal | 1 1 1 1 1 1 1 1 1 1 1 2 4 2 1 1 1 1 1 2 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Hemorrhage | 1 |
Nasolacrimal Duct, Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + A A + + + + + + + + + + + + + + + + + + A + + +|
Atrophy | 3 4 3 |
Cataract | |
Inflammation, Chronic | |
Synechia | 3 |
Anterior Chamber, Exudate | |
Cornea, Necrosis, Focal | 3 4 |
Retina, Degeneration | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + A A + + + + + + + + + + A + + + + + + + A + + +|
Hydronephrosis | |
Infarct | 2 |
Nephropathy | 4 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Hyperplasia, Focal | 2 |
Renal Tubule, Pigmentation | |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 3| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7|
DAY ON TEST | 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 5| 2| 3| 3| 3| 3| 3| 3| 3| 8| 3| 2| 3|
| 7| 6| 5| 7| 7| 7| 7| 7| 1| 7| 5| 5| 4| 3| 5| 7| 8| 7| 7| 7| 7| 8| 7| 8| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
5000 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | |
__________________________________________|__________________________________________________________________________
Page 48
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4| |
| 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + A + + + + + + + + + + + A + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + A + + A + + + + + +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + A + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + A + + + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + A + + A + + + + + +| 43 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X| 25 |
Clear Cell Focus | X X X X X X X X X X X X X | 27 |
Congestion | | 1 3.0|
Degeneration, Cystic, Focal | | 3 3.0|
Eosinophilic Focus | X X X | 11 |
Hemorrhage | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X| 11 |
Histiocytosis | 3 3 3 3 2 3 3 3 3 3 2 2 3 2 2 3 2 3 2 2 2 2 3 3 3| 50 2.5|
Hyperplasia, Focal, Histiocytic | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | 2 2 | 5 1.6|
Inflammation, Chronic | 2 2 2 1 1 2 1 2 1 3 1 1 1 2 2 2| 35 1.7|
Mixed Cell Focus | X X X X X X X X| 18 |
Bile Duct, Cyst | | 1 |
Bile Duct, Dilatation, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 2 2 3 2 1 1 2 2 1 2 2 2 2 3 1 2 3 2 2 2 1| 35 1.9|
Hepatocyte, Fatty Change, Focal | 3 3 3 2 2 3 1 2 2 2 1 3 2 2 2 3 2| 32 2.2|
Hepatocyte, Necrosis, Focal | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 2 2 3 3| 11 2.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4| |
| 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Centrilobular, Necrosis | | 1 4.0|
Oval Cell, Hyperplasia, Focal | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 8 |
Fat, Necrosis, Focal | 1 | 1 1.0|
Lymphatic, Angiectasis | | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Acinus, Atrophy, Focal | 1 1 1 1 1 1 2 3 3 1 1 3 1 1 2 1| 30 1.7|
Duct, Cyst, Focal, Multiple | 1 1 2 2 | 9 1.7|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Ulcer | 1 | 2 1.0|
Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 1 1 | 4 1.5|
|__________________________________________________________________________|____________|
Tongue | + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 2 2 2 2 2 2 1 2 1 2 2 1 1 1 2 2 2 3| 44 1.9|
Thrombosis | 4 | 5 3.4|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4| |
| 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 2 1.0|
Angiectasis | 2 3 3 | 4 2.8|
Cytoplasmic Alteration, Focal | 1 | 2 2.0|
Hemorrhage, Focal | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 1 1 2 1| 12 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 4 2.5|
Cyst | X X| 5 |
Pars Distalis, Degeneration, Cystic, | | |
Focal | 1 3 | 3 1.7|
Pars Distalis, Hyperplasia, Focal | 3 | 4 2.0|
Pars Distalis, Hypertrophy, Focal | 3 1| 4 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + A + + + + + + + + + + + A + + + + + + + + +| 45 |
C-Cell, Hyperplasia | 1 3 1 2 2 2 2 1 2 2 2 1 1 1 3 1 1 1 3| 35 1.7|
Follicle, Degeneration, Focal | 1 | 1 1.0|
Follicle, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1| 19 1.0|
Follicular Cell, Hyperplasia, Focal | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4| |
| 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 | 3 2.3|
Hyperplasia, Cystic | 3 | 1 3.0|
Inflammation, Chronic | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3| 2 3.0|
Periovarian Tissue, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 1 1 1 2 2 1 2 1 2 1 3 2| 26 1.5|
|__________________________________________________________________________|____________|
Vagina | + + + | 4 |
Angiectasis | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 3 | 2 3.0|
Hyperplasia, Focal, Histiocytic | 2 | 3 2.0|
Hyperplasia | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + +| 35 |
Hyperplasia, Plasma Cell | 3 | 1 3.0|
Mediastinal, Ectasia | 3 | 1 3.0|
Mediastinal, Hemorrhage | 3 | 3 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 | 6 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3| 1 3.0|
Pancreatic, Hemorrhage | | 2 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4| |
| 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pancreatic, Hyperplasia, Histiocytic | 3 3 3 | 7 3.1|
Pancreatic, Hyperplasia, Lymphoid | 3| 1 3.0|
Renal, Hyperplasia, Histiocytic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M + M M M M M M M M M M M M M M M M M| 4 |
Hyperplasia, Histiocytic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + A + + + + + + + + + + + A + + + + + + + + +| 47 |
Hemorrhage | | 1 3.0|
Hyperplasia, Histiocytic | | 2 3.0|
Hyperplasia, Lymphoid | 3| 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Accessory Spleen | | 1 |
Fibrosis, Focal | 2 | 1 2.0|
Inflammation, Granulomatous | 2 2 | 3 1.7|
Capsule, Infiltration Cellular, | | |
Focal, Mixed Cell | | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Hyperplasia, Lymphoid | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
Epidermis, Hyperplasia, Focal | | 2 2.5|
Lip, Cyst Epithelial Inclusion | 2 | 1 2.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4| |
| 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 | 2 2.5|
Hemorrhage, Focal | 1 | 2 1.5|
Meninges, Hemorrhage, Focal | | 1 3.0|
Thalamus, Mineralization, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 3 3 | 2 3.0|
Necrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 2 | 5 2.2|
Hemorrhage, Focal | | 2 2.0|
Hyperplasia, Focal, Histiocytic | 3 | 2 3.0|
Infiltration Cellular, Mixed Cell | | 1 3.0|
Inflammation, Chronic, Focal | 1 1 1 1 1 2 1 1 3 1 1 1 1 2 1 1 1 1 1 1 1| 43 1.2|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Hemorrhage | | 1 1.0|
Nasolacrimal Duct, Inflammation | 3 3 3 2 2 | 5 2.6|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 4| 2| 2| 2| 2| 2| 1| 3| 3| 6| 3| 1| 3| 6| 0| 3| 3| 3| 3| 4| 4| |
| 7| 7| 7| 5| 1| 9| 9| 9| 9| 9| 2| 5| 5| 8| 5| 7| 6| 6| 5| 6| 7| 7| 7| 2| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
5000 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + A + + + + + + + + + + + A + + + + + + + + +| 45 |
Atrophy | 3 | 4 3.3|
Cataract | 3 | 1 3.0|
Inflammation, Chronic | 3 | 1 3.0|
Synechia | 3 | 2 3.0|
Anterior Chamber, Exudate | 3 | 1 3.0|
Cornea, Necrosis, Focal | | 2 3.5|
Retina, Degeneration | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + A + + A + + + + + +| 43 |
Hydronephrosis | 2 | 1 2.0|
Infarct | 2 | 2 2.0|
Nephropathy | 2 1 1 3 1 1 2 1 2 1 1 1 1 3 1 1 1 3 2| 38 1.4|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 3.0|
Renal Tubule, Hyperplasia, Focal | | 1 2.0|
Renal Tubule, Pigmentation | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 3 3 | 2 3.0|
Inflammation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|
| 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X X X X X|
Congestion | 3 |
Degeneration, Cystic, Focal | 1 |
Eosinophilic Focus | |
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X X |
Histiocytosis | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperplasia, Focal, Histiocytic | |
Infiltration Cellular, Mixed Cell | 2 2 1 2 1 1 1 1 1 1 |
Inflammation, Chronic | 1 1 1 2 1 1 1|
Inflammation, Granulomatous | 1 |
Mixed Cell Focus | X X X X |
Bile Duct, Dilatation, Focal | 2 1 |
Bile Duct, Hyperplasia | 3 2 3 3 3 3 3 2 2 4 2 3 2 2 3 3 3 3 2 3 3 3 2 3 3|
Hepatocyte, Fatty Change, Focal | 1 1 1 2 1 2 2 2 1 2|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 1 3 2 2 1 3 2 |
Serosa, Inflammation, Chronic, Focal | 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Hemorrhage, Focal | 2 |
Fat, Necrosis, Focal | 3 3 3 3 |
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|
| 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 3 1 3 2 1 1 1 2 1 1 2 1 2|
Duct, Cyst, Focal, Multiple | 1 2 1 2 2 1 1 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 |
Inflammation | 2 |
Ulcer | 2 2 1 3 2 |
Epithelium, Hyperplasia | 2 3 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 |
Erosion | 3 |
Ulcer | 2 |
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 2 2 3 2 2 1 2 2 2 2 1 2 2|
Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 1 1 |
Cytoplasmic Alteration, Focal | 1 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage, Focal | |
Necrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|
| 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Vacuolization Cytoplasmic, Focal | 1 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X|
Pars Distalis, Hemorrhage, Focal | |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Hypertrophy, Focal | 2 1 2 1 1 3 2 |
Pars Nervosa, Inflammation | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 1 2 2 1 1 1 1 2 1 2 2 2 1 1 2 1 1 2 1|
Follicle, Degeneration, Focal | 1 1 1 |
Follicle, Mineralization | 1 |
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + + + |
Mediastinum, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Spermatocele | 3 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|
| 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Degeneration, Cystic | 3 2 3 |
Fibrosis | |
Hyperplasia, Cystic | 2 |
Inflammation, Chronic | 2 1 1 2 2 2 2 2 2 2 1 1 1 1|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 2 1 1 1 1 1 2 1 2 1 1 3 1 2 3|
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3 3 |
Cyst | |
Interstitial Cell, Hyperplasia, Focal| 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
Hyperplasia | 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Deep Cervical, Hyperplasia, Plasma | |
Cell | 3 |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Pancreatic, Ectasia | 2 |
Pancreatic, Hyperplasia, Histiocytic | 3 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Histiocytic | 3 3 |
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|
| 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X X |
Atrophy | 3 |
Fibrosis, Diffuse | 3 |
Fibrosis, Focal | 3|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Thymus | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 1 2 3 2 2 |
Fibrosis | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vertebra, Cyst | 4 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 |
Hemorrhage, Focal | 2 |
Meninges, Hemorrhage, Focal | |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|
| 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 |
Hemorrhage, Focal | |
Infiltration Cellular, Mixed Cell | 2 1 |
Inflammation, Chronic, Focal | 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
|__________________________________________________________________________|
Nose | + + + + + M + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Hemorrhage | 3 |
Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cataract | |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Histiocytic | 3 |
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Zymbal's Gland | + + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | 2 2|
Nephropathy | 2 1 1 2 2 2 2 2 1 3 3 1 1 2 1 2 1 2 2 2 1 1 1 1 3|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 |
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7|
DAY ON TEST | 3| 3| 1| 3| 0| 6| 0| 3| 6| 0| 0| 4| 3| 8| 3| 3| 2| 3| 3| 3| 3| 3| 4| 3| 3|
| 4| 4| 2| 0| 0| 7| 5| 4| 7| 0| 0| 2| 0| 5| 0| 0| 3| 0| 5| 5| 5| 4| 7| 4| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation | |
Ulcer | 3 |
__________________________________________|__________________________________________________________________________
Page 62
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3| |
| 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + + + + + + + + + + + + + A + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + A + + + + A + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + A A +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + A + + + + A A +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X| 31 |
Clear Cell Focus | X X X X X X X X X X X X X X X| 31 |
Congestion | 1 | 2 2.0|
Degeneration, Cystic, Focal | 1 2 1 | 4 1.3|
Eosinophilic Focus | X X X X | 4 |
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X | 5 |
Histiocytosis | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 2 1 1 1 1| 38 1.1|
Hyperplasia, Focal, Histiocytic | 1 | 1 1.0|
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 | 15 1.2|
Inflammation, Chronic | 1 1 2 1 1 1 1 1 1 1 1 | 18 1.1|
Inflammation, Granulomatous | | 1 1.0|
Mixed Cell Focus | X | 5 |
Bile Duct, Dilatation, Focal | | 2 1.5|
Bile Duct, Hyperplasia | 3 3 3 4 3 3 3 3 2 2 3 3 2 3 3 3 3 2 3 3 3 3 3| 48 2.8|
Hepatocyte, Fatty Change, Focal | 2 2 1 1 2 1 2 1 1 1 3 | 21 1.5|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 | 11 2.2|
Serosa, Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3| |
| 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + + + +| 13 |
Fat, Hemorrhage, Focal | | 1 2.0|
Fat, Necrosis, Focal | 3 3 2 2 3| 9 2.8|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 1 3 2 1 2 2 2 1 2 | 23 1.7|
Duct, Cyst, Focal, Multiple | 2 3 1 2 2 1 2 | 15 1.7|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 3 3.0|
Inflammation | | 1 2.0|
Ulcer | | 5 2.0|
Epithelium, Hyperplasia | 3 | 4 2.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 2 2.5|
Erosion | 1 1 | 3 1.7|
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 2 2 2 2 1 1 1 1 1 1 2 2 2 2 2 1 2 2 2 2| 40 1.7|
Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3| |
| 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1 1 2 1 | 9 1.2|
Cytoplasmic Alteration, Focal | 1 1 | 3 1.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage, Focal | 2 | 1 2.0|
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 2 1 2 1 | 6 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 2 1 1 1 | 7 1.4|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Cyst | | 4 |
Pars Distalis, Hemorrhage, Focal | 3 2 | 2 2.5|
Pars Distalis, Hyperplasia, Focal | 3 2 | 3 2.3|
Pars Distalis, Hyperplasia | 3 | 1 3.0|
Pars Distalis, Hypertrophy, Focal | 2 | 8 1.8|
Pars Nervosa, Inflammation | | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + A + + + + A A +| 47 |
C-Cell, Hyperplasia | 2 2 1 2 1 1 1 1 2 2 2 1 2 4 1 1 2 2| 41 1.5|
Follicle, Degeneration, Focal | 1 1 1 | 6 1.0|
Follicle, Mineralization | 1 1| 3 1.0|
Follicular Cell, Hyperplasia, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3| |
| 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + | 6 |
Mediastinum, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 3.0|
Spermatocele | | 1 3.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 3 | 5 2.8|
Fibrosis | 3 | 1 3.0|
Hyperplasia, Cystic | 3 2 | 3 2.3|
Inflammation, Chronic | 1 2 1 3 1 2 1 3 2 2 1 2 2 1 1 1| 30 1.6|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 3 1 2 2 2 3 1 1 3 3 | 27 1.7|
Epithelium, Hyperplasia, Focal | 2 1 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 3 3 3 3 3| 15 3.0|
Cyst | 3 | 1 3.0|
Interstitial Cell, Hyperplasia, Focal| 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + A A + + + + + + + + + + + + + A + + + + + + +| 47 |
Angiectasis | 3 | 1 3.0|
Atrophy | | 1 3.0|
Hyperplasia | | 2 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3| |
| 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node | + + + + + + + + + | 19 |
Deep Cervical, Hyperplasia, Plasma | | |
Cell | | 1 3.0|
Mediastinal, Ectasia | 3 3 | 2 3.0|
Mediastinal, Hemorrhage | 3 | 3 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 3 3 | 5 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 2 3.0|
Pancreatic, Ectasia | | 1 2.0|
Pancreatic, Hyperplasia, Histiocytic | | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 | 1 3.0|
Hyperplasia, Histiocytic | | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 3 |
Atrophy | 1 3 | 3 2.3|
Fibrosis, Diffuse | | 1 3.0|
Fibrosis, Focal | 3 | 2 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + M + + + + + + + + + + + + + + +| 47 |
Dilatation | 2 4 2 2 2 3 3 | 12 2.3|
Fibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3| |
| 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 3 | 1 3.0|
Hyperkeratosis, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vertebra, Cyst | | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 3 | 4 3.0|
Hemorrhage, Focal | | 1 2.0|
Meninges, Hemorrhage, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 3 | 4 2.8|
Hemorrhage, Focal | 3 1 2 3| 4 2.3|
Infiltration Cellular, Mixed Cell | 2 | 3 1.7|
Inflammation, Chronic, Focal | 2 | 3 1.3|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 2 | 1 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Suppurative | 2 | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 5| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 8| 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 8| 3| 3| 5| 3| 0| 6| 3| |
| 0| 0| 2| 7| 0| 4| 4| 4| 5| 5| 5| 4| 4| 2| 0| 0| 0| 9| 5| 5| 3| 4| 9| 4| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + A + + + + + + + + + + + + + + + + + + + A + +| 48 |
Cataract | 3 3 | 2 3.0|
Retina, Degeneration | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Histiocytic | | 1 3.0|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + A + + + + + + + + + + + + + + A + + + + + + +| 48 |
Congestion | 3 | 1 3.0|
Cyst | | 2 2.0|
Nephropathy | 2 2 1 2 2 2 2 1 1 2 2 1 1 2 2 1 2 1 1 1 1 1| 47 1.6|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 1 2.0|
Renal Tubule, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Inflammation | 1 | 1 1.0|
Ulcer | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|
| 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
625 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + A|
Congestion | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + A + + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + A + + + A + + + + + + + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X X |
Degeneration, Cystic, Focal | |
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X |
Histiocytosis | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 2 1|
Infiltration Cellular, Mixed Cell | 1 1 2 1 |
Inflammation, Chronic | 1 1 1 1 1 1 1 1 1 1 1 2 1 1 |
Mixed Cell Focus | X X X X |
Bile Duct, Dilatation, Focal | 2 |
Bile Duct, Hyperplasia | 3 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 2 3 2 3 2|
Hepatocyte, Fatty Change, Focal | 2 2 2 1 3 2 1 3 3 3 2 1 2 |
Hepatocyte, Necrosis, Focal | |
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 2 4 4|
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 3 |
|__________________________________________________________________________|
Oral Mucosa | + |
Foreign Body | 3 |
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|
| 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
625 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Chronic, Focal | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + A|
Acinus, Atrophy, Focal | 1 2 1 1 1 2 1 2 1 1 1 2 2 |
Duct, Cyst, Focal, Multiple | 1 2 2 2 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis, Focal | |
Ulcer | |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Focal | |
Ulcer | 3 |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Cyst | |
|__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 1 1 1 1 2 1 2 1 2 2 2|
Thrombosis | 3 3 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 2 |
Angiectasis | |
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|
| 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
625 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Cytoplasmic Alteration, Focal | 1 |
Degeneration, Cystic | 4 |
Necrosis | 4 |
Vacuolization Cytoplasmic, Focal | 1 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 |
Necrosis | 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Pars Distalis, Degeneration, Cystic, | |
Focal | |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hypertrophy, Focal | 2 1 1 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + A + + + + + + + A|
C-Cell, Hyperplasia | 1 1 2 1 2 2 2 1 2 1 1 1 2 1 2 1 1 1 3 |
Follicle, Cyst | X X |
Follicle, Degeneration, Focal | 1 1 |
Follicle, Mineralization | |
Follicular Cell, Hyperplasia, Focal | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
|__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|
| 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
625 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Degeneration, Cystic | 3 |
Hyperplasia, Cystic | |
Inflammation, Chronic | 2 3 1 1 1 2 1 2 2 1 2 2 2 2|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 1 3 1 3 1 2 3 1 3 2|
Epithelium, Hyperplasia, Focal | 1 1 1 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + A + + A|
Hyperplasia, Plasma Cell | 3 |
Mediastinal, Ectasia | 1 3 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia | |
Mediastinal, Hyperplasia, Plasma Cell| 4 |
Pancreatic, Hemorrhage | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + A + + + + + + + A|
Ectasia | 3 |
Hyperplasia, Histiocytic | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +|
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | |
Infarct | |
Inflammation, Granulomatous | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|
| 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
625 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Dilatation | 4 3 3 |
Inflammation, Chronic, Focal | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Ulcer | |
Epidermis, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 3 3 |
Hemorrhage, Focal | 2 3 |
Meninges, Congestion, Focal | 2 |
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
Hemorrhage, Focal | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage, Focal | 3 |
Inflammation, Chronic, Focal | 1 3 |
Alveolar Epithelium, Hyperplasia, | |
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 2| 7| 5| 7| 6|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 9| 3| 3| 3| 2| 3| 3| 1| 7| 3| 4| 3| 3|
| 4| 3| 4| 0| 0| 0| 0| 7| 0| 0| 0| 0| 4| 4| 4| 4| 1| 4| 4| 6| 5| 0| 7| 0| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
625 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Focal | 1 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + A + + + + + + + A|
Cataract | 3 |
Anterior Chamber, Exudate | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + A|
Cyst | |
Infarct | 4 |
Nephropathy | 1 3 1 1 1 1 2 1 1 2 1 2 2 2 2 1 2 3 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 1 |
Renal Tubule, Hyperplasia, Focal | 1 |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________|__________________________________________________________________________
Page 75
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3| |
| 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
625 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + A + + + + + + + + + +| 46 |
Congestion | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + A + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + A + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X | 26 |
Clear Cell Focus | X X X X X X X X X X X X X X | 28 |
Degeneration, Cystic, Focal | 2 1 1 | 3 1.3|
Eosinophilic Focus | X X| 3 |
Hepatodiaphragmatic Nodule | X | 2 |
Histiocytosis | 2 2 2 2 1 2 1 1 2 1 1 2 2 1 1 1 2 1 1 1 2 2 1 2 1| 45 1.4|
Infiltration Cellular, Mixed Cell | 1 | 5 1.2|
Inflammation, Chronic | 2 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 | 32 1.2|
Mixed Cell Focus | X X X | 7 |
Bile Duct, Dilatation, Focal | 2 | 2 2.0|
Bile Duct, Hyperplasia | 3 3 3 3 3 3 3 2 2 3 3 3 3 3 3 3 3 3 3 2 2 3 3 3| 48 2.9|
Hepatocyte, Fatty Change, Focal | 1 1 1 3 2 1 2 1 1 2 1 | 24 1.8|
Hepatocyte, Necrosis, Focal | 2 2 | 2 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 2 3 3 2 3 | 14 2.9|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + +| 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3| |
| 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
625 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis, Focal | 3 4 2 | 4 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Foreign Body | | 1 3.0|
Inflammation, Chronic, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Atrophy, Focal | 1 2 3 2 2 2 1 3 1 2 3 | 24 1.7|
Duct, Cyst, Focal, Multiple | 1 2 2 2 2 2 2 | 12 1.8|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis, Focal | 2 | 1 2.0|
Ulcer | 3 3 | 2 3.0|
Epithelium, Hyperplasia | 3 3 | 3 2.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Inflammation, Focal | 2 | 1 2.0|
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Tongue | + +| 3 |
Epithelium, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3| |
| 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
625 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Cardiomyopathy | 2 2 1 2 2 2 2 1 1 2 2 2 2 1 1 2 3 1 2 2 1| 38 1.7|
Thrombosis | | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1 1 1 | 6 1.2|
Angiectasis | 2 | 1 2.0|
Cytoplasmic Alteration, Focal | 2 | 2 1.5|
Degeneration, Cystic | | 1 4.0|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic, Focal | 1 | 5 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 1.0|
Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + I + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + + + +| 49 |
Cyst | X | 2 |
Pars Distalis, Degeneration, Cystic, | | |
Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
Pars Distalis, Hypertrophy, Focal | 1 2 1 1 | 9 1.6|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + A + + + + + + + + + A + + + + + + + + + +| 46 |
C-Cell, Hyperplasia | 1 2 1 4 4 1 1 1 1 | 28 1.6|
Follicle, Cyst | X | 3 |
Follicle, Degeneration, Focal | 1 3 | 4 1.5|
Follicle, Mineralization | 1 1 1| 3 1.0|
Follicular Cell, Hyperplasia, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3| |
| 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
625 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 2 |
|__________________________________________________________________________|____________|
Tissue NOS | + + +| 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 2 | 3 2.7|
Hyperplasia, Cystic | 2 | 1 2.0|
Inflammation, Chronic | 2 1 2 1 1 2 2 2 1 1 2 2 1 1 | 28 1.6|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 1 1 3 3 2 2 2 1 3 2 2| 24 2.0|
Epithelium, Hyperplasia, Focal | 1 2 | 6 1.3|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 1 3 | 10 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 18 |
Hyperplasia, Plasma Cell | | 1 3.0|
Mediastinal, Ectasia | | 2 2.0|
Mediastinal, Hemorrhage | 3 | 2 3.0|
Mediastinal, Hyperplasia | 3 | 1 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 4 | 2 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3| |
| 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
625 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pancreatic, Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M + M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Ectasia | | 1 3.0|
Hyperplasia, Histiocytic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + A + + + + + + + + + +| 48 |
Fibrosis, Focal | 3 | 2 3.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Infarct | 3 | 1 3.0|
Inflammation, Granulomatous | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + M M + + + + M + + + + +| 46 |
Dilatation | 2 2 2 2| 7 2.6|
Inflammation, Chronic, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 2 | 1 2.0|
Ulcer | 3 | 1 3.0|
Epidermis, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | +| 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3| |
| 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
625 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 3 4 | 6 3.2|
Hemorrhage, Focal | 2 3 | 4 2.5|
Meninges, Congestion, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
Hemorrhage, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 2 | 1 2.0|
Hemorrhage, Focal | | 1 3.0|
Inflammation, Chronic, Focal | 2 | 3 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 | 4 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1| 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Cataract | | 1 3.0|
Anterior Chamber, Exudate | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 2| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 0| 9| 3| 3| 3| 7| 1| 3| 3| 3| 3| 7| 3| 3| 6| 3| 3| 3| 7| 3| 0| 3| |
| 0| 0| 0| 0| 5| 0| 0| 0| 7| 2| 0| 4| 4| 4| 5| 4| 4| 5| 4| 4| 0| 7| 0| 0| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
625 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 3 | 1 3.0|
Infarct | 1 | 2 2.5|
Nephropathy | 1 1 1 3 1 1 1 3 2 2 1 2 1 1 2 2 1 1 2 1 2 1 2 2| 43 1.6|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 3 2.0|
Renal Tubule, Hyperplasia, Focal | | 1 1.0|
Renal Tubule, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|
| 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + A + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + A + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + A + A + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Basophilic Focus | X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X X X|
Degeneration, Cystic, Focal | |
Eosinophilic Focus | X X X X X |
Hepatodiaphragmatic Nodule | X X X |
Histiocytosis | 2 2 2 2 2 2 2 2 2 1 1 2 2 2 1 2 2 2 2 1 2 2 2 2 2|
Hyperplasia, Focal, Histiocytic | |
Infiltration Cellular, Mixed Cell | 1 2 2 |
Inflammation, Chronic | 2 1 1 1 2 2 1 1 1 2 1 2 2 1|
Mixed Cell Focus | X X X X X X X|
Thrombosis | 3 |
Bile Duct, Dilatation, Focal | 1 |
Bile Duct, Hyperplasia | 3 2 3 3 3 3 3 3 3 2 3 3 2 3 3 3 3 3 3 3 3 3 3 2 3|
Hepatocyte, Fatty Change, Focal | 2 2 1 1 1 2 1 2 2 2 3 2 2 2 2 1 2 2|
Hepatocyte, Necrosis, Focal | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 1 3 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + |
Inflammation, Chronic | 2 |
Fat, Necrosis, Focal | 2 3 3 3 4 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|
| 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Oral Mucosa | |
Hyperplasia, Focal, Squamous | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Angiectasis | |
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 1 3 2 3 3 1 3 3 2 2 3 3|
Duct, Cyst, Focal, Multiple | 1 2 2 2 3 2 3 1 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
Ulcer | 3 2 |
Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
Hyperplasia, Focal, Histiocytic | |
Ulcer | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 2 2 1 1 2 1 1 1 2 2 2 2 1 |
Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Cytoplasmic Alteration, Focal | |
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|
| 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Necrosis | |
Vacuolization Cytoplasmic, Focal | 2 1 1 1 1 2 2 2 1 1 2 1|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + M + + + + + + + A + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hypertrophy, Focal | 3 1 1 1 2 1 3 2 1 1|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + A + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 2 1 1 2 1 2 1 1 1 1 1|
Follicle, Cyst | |
Follicle, Degeneration, Focal | 1 2 2 1 |
Follicle, Mineralization | 1 1 1 1 1 |
Follicular Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + |
Inflammation, Chronic, Focal | 2 |
|__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|
| 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Degeneration, Cystic | 2 |
Inflammation, Chronic | 1 3 2 2 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 1 2 1 3 1 3 3 1 2 1 2 3|
Epithelium, Hyperplasia, Focal | 2 1 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3|
Interstitial Cell, Hyperplasia, Focal| 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + |
Deep Cervical, Hyperplasia, | |
Histiocytic | 3 |
Mediastinal, Hemorrhage | 3 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Pancreatic, Hemorrhage | 2 2 |
Pancreatic, Hyperplasia, Histiocytic | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M + M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + A + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 |
Inflammation, Granulomatous | 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|
| 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Thymus | + + + + + + + + M + + M + + + + + + M + + + + + +|
Angiectasis | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + M + + + + M + + M + + + + M M M + + + + M +|
Dilatation | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 3 |
Hyperkeratosis, Focal | 2 |
Epidermis, Hyperplasia, Focal | 1 |
Subcutaneous Tissue, Edema | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | |
Hemorrhage, Focal | 1 3 |
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | 2 3 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic, Focal | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 7| 7| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 4| 3| 3| 3| 9| 3| 3| 3| 9| 0| 4| 0| 3| 3| 3| 3| 3| 5| 3| 1| 3|
| 0| 0| 4| 4| 2| 4| 4| 4| 4| 8| 5| 5| 3| 5| 2| 6| 0| 0| 0| 0| 0| 3| 4| 2| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolus, Proteinosis | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Inflammation, Suppurative | 2 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Lymphoid | |
Inflammation | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + A + + + + + + + + +|
Infarct | |
Nephropathy | 1 2 1 1 2 1 1 2 1 1 1 1 1 2 1 1 1 2 1 1 1 1 2|
Pelvis, Dilatation | 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 4 |
Renal Tubule, Pigmentation | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hyperplasia | 3 |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 88
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| |
DAY ON TEST | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A A + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A A + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A A + + + + + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 2.0|
Basophilic Focus | X X X X X X X X X X X X X X X X| 30 |
Clear Cell Focus | X X X X X X X X X X X X X X X X | 29 |
Degeneration, Cystic, Focal | 2 | 1 2.0|
Eosinophilic Focus | X X | 7 |
Hepatodiaphragmatic Nodule | X X| 5 |
Histiocytosis | 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2| 50 1.9|
Hyperplasia, Focal, Histiocytic | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 1| 5 1.6|
Inflammation, Chronic | 1 1 1 2 1 1 2 1 1 1 2 1 1 1 1 1 1| 31 1.3|
Mixed Cell Focus | X X X X| 11 |
Thrombosis | | 1 3.0|
Bile Duct, Dilatation, Focal | 2 | 2 1.5|
Bile Duct, Hyperplasia | 4 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2 3 3 3 1| 49 2.9|
Hepatocyte, Fatty Change, Focal | 1 2 2 1 2 3 2 2 1 2 2 3 2 2 2 2 2 3 2| 37 1.9|
Hepatocyte, Necrosis, Focal | | 1 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 1 1 2| 12 2.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| |
DAY ON TEST | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + | 11 |
Inflammation, Chronic | | 1 2.0|
Fat, Necrosis, Focal | | 6 3.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
Hyperplasia, Focal, Squamous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 3 | 1 3.0|
Acinus, Atrophy, Diffuse | 3 | 1 3.0|
Acinus, Atrophy, Focal | 2 1 1 3 2 1 1 2 1 2 3 | 24 2.1|
Duct, Cyst, Focal, Multiple | 2 1 1 2 2 2 2 | 16 1.9|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 2.0|
Ulcer | | 2 2.5|
Epithelium, Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
Erosion | | 1 1.0|
Hyperplasia, Focal, Histiocytic | 1 | 1 1.0|
Ulcer | 3 | 2 2.5|
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| |
DAY ON TEST | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Cardiomyopathy | 2 2 1 3 2 1 3 1 2 2 2 1 2 2 2 2 1 1 1 | 36 1.6|
Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1 2 1 | 5 1.2|
Cytoplasmic Alteration, Focal | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 | 13 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 3 1.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M I + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | 2 3 3 2 | 4 2.5|
Cyst | X X | 6 |
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 2 | 2 1.5|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
Pars Distalis, Hypertrophy, Focal | 3 2 2 2 3 1 2 3 1 1| 20 1.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
C-Cell, Hyperplasia | 1 2 1 3 4 2 1 1 1 1 3 1 1 1| 26 1.5|
Follicle, Cyst | X | 1 |
Follicle, Degeneration, Focal | 1 1 1 1 | 8 1.3|
Follicle, Mineralization | | 5 1.0|
Follicular Cell, Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| |
DAY ON TEST | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 3 |
Inflammation, Chronic, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Tissue NOS | + + + + | 6 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 | 2 2.5|
Inflammation, Chronic | 2 2 2 2 1 2 2 1 2 2 2 2 2 1 2 | 21 1.9|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 1 1 2 3 2 1 1 1 1 2 2 1| 28 1.6|
Epithelium, Hyperplasia, Focal | 1 | 5 1.2|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 3 | 8 3.0|
Interstitial Cell, Hyperplasia, Focal| 1 | 6 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + A + + + + + + + + + + + + A + + + +| 48 |
Hyperplasia | | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 26 |
Deep Cervical, Hyperplasia, | | |
Histiocytic | | 1 3.0|
Mediastinal, Hemorrhage | | 2 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| |
DAY ON TEST | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mediastinal, Hyperplasia, Histiocytic| 3 | 2 3.0|
Mediastinal, Hyperplasia, Plasma Cell| 3 | 2 3.0|
Pancreatic, Hemorrhage | 3 | 3 2.3|
Pancreatic, Hyperplasia, Histiocytic | 3| 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Accessory Spleen | X | 1 |
Fibrosis, Focal | 3 | 2 3.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | | 1 3.0|
Inflammation, Granulomatous | | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + I + + + + + + + + + + + + + + +| 46 |
Angiectasis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + M| 41 |
Dilatation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 2| 2 2.5|
Hyperkeratosis, Focal | | 1 2.0|
Epidermis, Hyperplasia, Focal | | 1 1.0|
Subcutaneous Tissue, Edema | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| |
DAY ON TEST | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 | 1 3.0|
Hemorrhage, Focal | 3 | 3 2.3|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 | 3 2.3|
Infiltration Cellular, Mixed Cell | 2| 1 2.0|
Inflammation, Chronic, Focal | 1 2 1 | 4 1.3|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 | 3 1.7|
Alveolus, Proteinosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 1.0|
Inflammation, Suppurative | 1 | 4 1.8|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| |
DAY ON TEST | 5| 0| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 0| 3| 3| 3| 3| |
| 0| 0| 0| 0| 0| 4| 4| 5| 7| 5| 5| 5| 5| 5| 4| 4| 4| 0| 0| 8| 0| 0| 0| 5| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
1250 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Inflammation | 1 3 | 2 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + +| 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + A + + + + + + + + + + + + + + + + +| 48 |
Infarct | 3 | 1 3.0|
Nephropathy | 3 1 1 2 1 2 2 2 1 1 2 2 1 2 1 1 1 2 1 3 1 2 2 2| 47 1.4|
Pelvis, Dilatation | | 1 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 2 3.0|
Renal Tubule, Pigmentation | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Muscularis, Hyperplasia | | 1 3.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|
| 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + A + + A + + A + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + A + + A + + + +|
Edema | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + A + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + M + + + + + + + + + + + + A + + M + + A + + + A|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + A + + A + + + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X X X X X X |
Degeneration, Cystic, Focal | 2 1 2 2 2 3 |
Eosinophilic Focus | X X X X X X |
Hepatodiaphragmatic Nodule | |
Histiocytosis | 3 2 2 3 2 2 2 2 2 2 3 2 3 2 2 3 1 3 2 2 3 2 2 2 3|
Hyperplasia, Focal, Histiocytic | |
Infiltration Cellular, Mixed Cell | 2 2 1 1 1 1 1 1 |
Inflammation, Chronic | 2 2 1 1 2 1 1 1 1 2 1 1 1 2 |
Mixed Cell Focus | X X X X X X X X X X X X X |
Bile Duct, Dilatation, Focal | |
Bile Duct, Hyperplasia | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3|
Hepatocyte, Fatty Change, Focal | 1 3 3 3 3 2 3 3 2 2 2 3 2 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 3 2 2 2 3 2 4 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Inflammation, Chronic | |
Artery, Thrombosis | 3 |
Fat, Necrosis, Focal | 3 3 2 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + A + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 96
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|
| 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Chronic | |
Acinus, Atrophy, Focal | 2 2 2 3 1 1 1 2 1 3 1 |
Duct, Cyst, Focal, Multiple | 2 2 2 2 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + A + + + + + + +|
Diverticulum | 2 |
Inflammation | 2 |
Ulcer | 3 2 |
Epithelium, Hyperplasia | 1 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + A + + + + + + +|
Cyst | 2 |
Erosion | 1 3 1 |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 1 2 2 1 2 2 1 2 1 3 2 2 2 2 2|
Thrombosis | 2 4 3|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 1 1 1 |
Cytoplasmic Alteration, Focal | 1 |
Hyperplasia, Focal | 1 |
Vacuolization Cytoplasmic, Focal | 2 2 1 |
Capsule, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 97
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|
| 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Islets, Pancreatic | + + + + + + + + + + + + + + + + + A + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + I M + + + + + + + +|
Angiectasis | 3 |
Cyst | X |
Fibrosis, Focal | 3 |
Hemorrhage | 3 |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hypertrophy, Focal | 1 3 2 4 2 2 1 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + A + + A + + + A|
C-Cell, Hyperplasia | 1 1 4 1 1 2 1 2 1 1 2 2 2 2 1 2 |
Follicle, Cyst | X |
Follicle, Degeneration, Focal | 2 1 |
Follicle, Mineralization | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | |
|__________________________________________________________________________|
Tissue NOS | + + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Hemorrhage | 3 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Degeneration, Cystic | 3 2 3|
__________________________________________|__________________________________________________________________________|
Page 98
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|
| 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation, Chronic | 2 2 1 1 1 1 1 1 2 2 2 2 1 |
|__________________________________________________________________________|
Prostate | + I + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 2 2 3 2 2 2 2 3 2 1 2 2 2 3 2 1 2 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 3 3 3 3|
Interstitial Cell, Hyperplasia, Focal| 2 1 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + +|
Mediastinal, Ectasia | 3 3 |
Mediastinal, Hemorrhage | 3 |
Mediastinal, Hyperplasia, Histiocytic| 3 |
Mediastinal, Hyperplasia, Plasma Cell| 3 |
Pancreatic, Fibrosis | 3 |
Pancreatic, Hemorrhage | 3 |
Pancreatic, Hyperplasia, Histiocytic | 3 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M + M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Histiocytic | 3 |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Infarct | 3 |
__________________________________________|__________________________________________________________________________|
Page 99
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|
| 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Inflammation, Granulomatous | 3 1 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M + + + + + + + + M M|
Dilatation | 4 |
Fibrosis | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Focal | 1 |
Subcutaneous Tissue, Fibrosis, Focal | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | |
Hemorrhage, Focal | 3 3 |
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
Hemorrhage, Focal | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Infiltration Cellular, Mixed Cell | 2 2 |
Inflammation, Chronic, Focal | |
Inflammation, Focal | 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 100
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
_____________________________________________________________________________________________________________________
| 6| 6| 7| 6| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 3| 6| 7| 7| 6| 7| 7| 7| 5|
DAY ON TEST | 2| 8| 3| 5| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 0| 3| 3| 7| 3| 3| 3| 8|
| 2| 9| 4| 0| 4| 4| 0| 0| 0| 4| 4| 4| 4| 4| 2| 4| 9| 7| 4| 4| 0| 4| 4| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2500 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Inflammation, Suppurative | 3 1 |
Nasolacrimal Duct, Inflammation | 2 2 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + A + + A + + A + + + +|
Cataract | |
Anterior Chamber, Exudate | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 2 |
Nephropathy | 3 2 1 1 2 1 2 2 2 1 2 1 2 2 2 2 1 2 2 1 2 1 |
Pelvis, Dilatation | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 2 |
|__________________________________________________________________________|
Urethra | |
Muscularis, Inflammation, Chronic | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation | |
__________________________________________|__________________________________________________________________________
Page 101
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3| |
| 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2500 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + + + +| 46 |
Edema | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + A +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + + + + A +| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X| 36 |
Clear Cell Focus | X X X X X X X X X X X X X X X X X| 31 |
Degeneration, Cystic, Focal | 2 | 7 2.0|
Eosinophilic Focus | X X X X X X| 12 |
Hepatodiaphragmatic Nodule | X X X X | 4 |
Histiocytosis | 2 2 2 3 2 3 2 2 3 2 2 2 2 2 2 2 3 2 3 2 2 2 3 2 2| 50 2.3|
Hyperplasia, Focal, Histiocytic | 2 2 2 | 3 2.0|
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 1 1 1 1| 17 1.1|
Inflammation, Chronic | 2 1 3 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 36 1.3|
Mixed Cell Focus | X X X X X X X X X X X X X X | 27 |
Bile Duct, Dilatation, Focal | 2 1 | 2 1.5|
Bile Duct, Hyperplasia | 3 3 3 3 2 3 3 3 3 2 3 3 3 3 3 3 3 3 3 3 3 3 3| 42 3.0|
Hepatocyte, Fatty Change, Focal | 3 2 1 2 2 3 3 3 2 3 2 3 3 3 3 3 3 3| 33 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 3 2 1 2 3 2 3 | 18 2.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3| |
| 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2500 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Artery, Thrombosis | | 1 3.0|
Fat, Necrosis, Focal | 3 | 5 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3 | 1 3.0|
Acinus, Atrophy, Focal | 2 1 3 1 2 2 3 1 1 1 3 3 4 1| 25 1.9|
Duct, Cyst, Focal, Multiple | 3 2 2 2 1 | 10 1.9|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Diverticulum | | 1 2.0|
Inflammation | 1 3 | 3 2.0|
Ulcer | 2 | 3 2.3|
Epithelium, Hyperplasia | 2 | 4 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 2.0|
Erosion | 2 2 2 | 6 1.8|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 1 2 2 2 2 2 2 2 2 1 3 3 2 2 1 1 2 1| 39 1.8|
Thrombosis | 2 | 4 2.8|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3| |
| 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2500 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Accessory Adrenal Cortical Nodule | 1 1 1 1| 9 1.0|
Cytoplasmic Alteration, Focal | 1 | 2 1.0|
Hyperplasia, Focal | | 1 1.0|
Vacuolization Cytoplasmic, Focal | 1 1 1 1 | 7 1.3|
Capsule, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 2 | 2 2.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Angiectasis | | 1 3.0|
Cyst | | 1 |
Fibrosis, Focal | | 1 3.0|
Hemorrhage | | 1 3.0|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
Pars Distalis, Hypertrophy, Focal | 2 2 2 3 1 2 2 2 2 1 2 2 2| 22 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + A + + + + + + + + + + + + + + + + + A +| 44 |
C-Cell, Hyperplasia | 2 2 1 2 2 2 1 1 1 2 1 3 2| 29 1.7|
Follicle, Cyst | X X X X | 5 |
Follicle, Degeneration, Focal | 1 1 | 4 1.3|
Follicle, Mineralization | 1 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + | 1 |
|__________________________________________________________________________|____________|
Tissue NOS | + + + | 5 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3| |
| 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2500 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 3.0|
Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | | 3 2.7|
Inflammation, Chronic | 2 2 2 2 2 2 2 2 1 2| 23 1.7|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic | 3 2 2 4 3 1 2 2 2 1 1 1 3 2 2 1| 36 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 3 3 4 | 10 3.1|
Interstitial Cell, Hyperplasia, Focal| 2 2 1 | 7 1.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 3 | 4 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 27 |
Mediastinal, Ectasia | 3 | 3 3.0|
Mediastinal, Hemorrhage | 3 3 | 3 3.0|
Mediastinal, Hyperplasia, Histiocytic| 3 3| 3 3.0|
Mediastinal, Hyperplasia, Plasma Cell| | 1 3.0|
Pancreatic, Fibrosis | | 1 3.0|
Pancreatic, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3| |
| 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2500 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pancreatic, Hyperplasia, Histiocytic | 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M + M M M M M M M M M M M M M| 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 3.0|
Hyperplasia, Histiocytic | 3 | 2 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Spleen | X | 3 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Infarct | 3 | 2 3.0|
Inflammation, Granulomatous | | 2 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + M + + + M I + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + M + + + + + + + + + + + M + +| 45 |
Dilatation | 2 | 2 3.0|
Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 3| 1 3.0|
Inflammation, Focal | | 1 1.0|
Subcutaneous Tissue, Fibrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3| |
| 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2500 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 2 | 1 2.0|
Hemorrhage, Focal | 1 | 3 2.3|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
Hemorrhage, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 2 3.0|
Infiltration Cellular, Mixed Cell | | 2 2.0|
Inflammation, Chronic, Focal | 1 1 | 2 1.0|
Inflammation, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 2.0|
Inflammation, Suppurative | | 2 2.0|
Nasolacrimal Duct, Inflammation | 3 | 4 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + A + + + + + + + + + + + + + + + + + A +| 45 |
Cataract | 2 2 | 2 2.0|
Anterior Chamber, Exudate | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 92013-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 12/06/04
Route: DOSED FEED Time: 08:41:26
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 5| 5| 3| 2| 2| 2| 2| 3| 2| 2| 2| 2| 3| 6| 3| 3| 3| 6| 9| 3| |
| 5| 5| 4| 4| 0| 1| 3| 0| 9| 9| 9| 8| 5| 2| 9| 9| 9| 0| 3| 0| 4| 4| 6| 3| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
2500 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | 2 2 | 4 2.3|
Nephropathy | 2 2 2 2 1 1 1 2 2 2 1 1 1 3 2 2 2 1 3 2 2 2 1 1| 46 1.7|
Pelvis, Dilatation | 3 | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Urethra | + | 1 |
Muscularis, Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
Inflammation | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
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---------- END OF REPORT ----------
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