TDMS Study 92013-06 Pathology Tables
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
FINAL #1 MICE
Facility: Southern Research Institute
Chemical CAS #: 822-36-6
Lock Date: 09/13/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 3 4 3 3
Natural Death 4 6 4 7
Survivors
Terminal Sacrifice 42 40 41 39
Natural Death 1 2 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (48) (46) (46)
Edema 3 (6%) 4 (8%) 2 (4%) 2 (4%)
Intestine Small, Jejunum (50) (48) (47) (47)
Hyperplasia, Lymphoid 4 (8%) 2 (4%) 2 (4%)
Intestine Small, Ileum (48) (45) (48) (48)
Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%)
Basophilic Focus 1 (2%) 1 (2%) 1 (2%)
Cyst 3 (6%) 1 (2%)
Eosinophilic Focus 1 (2%) 2 (4%) 1 (2%)
Hematopoietic Cell Proliferation 6 (12%) 5 (10%) 3 (6%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 3 (6%) 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 3 (6%) 1 (2%) 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%)
Necrosis, Focal 4 (8%) 3 (6%) 2 (4%) 6 (12%)
Centrilobular, Necrosis 1 (2%) 1 (2%) 1 (2%)
Hepatocyte, Hypertrophy 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Kupffer Cell, Pigmentation 1 (2%) 1 (2%) 2 (4%)
Mesentery (3) (7) (7) (4)
Hemorrhage 1 (25%)
Fat, Necrosis 3 (100%) 3 (43%) 3 (43%) 3 (75%)
Pancreas (49) (48) (48) (49)
Atrophy 1 (2%)
Cyst 3 (6%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Cytoplasmic Alteration 1 (2%) 1 (2%)
Salivary Glands (50) (48) (50) (49)
Atrophy 2 (4%)
Hyperplasia, Lymphoid 3 (6%) 4 (8%) 3 (6%) 3 (6%)
Stomach, Forestomach (50) (50) (50) (50)
Diverticulum 2 (4%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Hyperplasia 3 (6%) 5 (10%) 2 (4%) 5 (10%)
Stomach, Glandular (49) (49) (50) (49)
Erosion 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Inflammation, Chronic 1 (2%) 1 (2%)
Mineralization 4 (8%)
Thrombosis 1 (2%)
Myocardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 9 (18%) 9 (18%) 9 (18%) 5 (10%)
Hyperplasia, Diffuse 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (4%)
Capsule, Hyperplasia 2 (4%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 (2%) 2 (4%)
Islets, Pancreatic (49) (48) (47) (49)
Hyperplasia 1 (2%) 2 (4%)
Parathyroid Gland (49) (49) (48) (47)
Cyst 1 (2%) 5 (10%) 2 (4%)
Pituitary Gland (49) (46) (49) (50)
Pars Distalis, Cyst 1 (2%) 3 (7%) 4 (8%)
Pars Distalis, Hyperplasia, Focal 2 (4%) 4 (9%) 1 (2%)
Thyroid Gland (50) (49) (50) (48)
Follicle, Cyst 20 (40%) 22 (45%) 29 (58%) 30 (63%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49) (50) (50)
Inflammation, Chronic 1 (2%) 3 (6%) 5 (10%) 3 (6%)
Ovary (48) (49) (49) (50)
Angiectasis 9 (19%) 9 (18%) 7 (14%) 6 (12%)
Cyst 16 (33%) 20 (41%) 14 (29%) 19 (38%)
Inflammation, Granulomatous 1 (2%)
Corpus Luteum, Hyperplasia 1 (2%)
Granulosa Cell, Hyperplasia 1 (2%) 1 (2%)
Thecal Cell, Hyperplasia 1 (2%)
Uterus (50) (50) (50) (50)
Angiectasis 3 (6%) 3 (6%)
Hyperplasia, Cystic 45 (90%) 47 (94%) 46 (92%) 47 (94%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%) 3 (6%)
Metaplasia, Squamous 2 (4%) 3 (6%) 1 (2%) 5 (10%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 13 (26%) 13 (26%) 10 (20%) 17 (34%)
Infiltration Cellular, Mast Cell 1 (2%)
Lymph Node (3) (9) (12) (7)
Bronchial, Hyperplasia, Lymphoid 1 (8%)
Iliac, Hemorrhage 1 (11%) 1 (14%)
Iliac, Hyperplasia, Lymphoid 2 (22%) 1 (8%) 1 (14%)
Iliac, Pigmentation 1 (14%)
Inguinal, Hyperplasia, Lymphoid 2 (22%) 1 (8%)
Mediastinal, Hyperplasia, Lymphoid 2 (22%)
Renal, Hematopoietic Cell Proliferation 1 (8%)
Renal, Hyperplasia, Lymphoid 1 (8%) 1 (14%)
Renal, Pigmentation 1 (14%)
Lymph Node, Mandibular (47) (47) (48) (48)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Hemorrhage 1 (2%) 3 (6%)
Hyperplasia, Lymphoid 6 (13%) 8 (17%) 7 (15%) 13 (27%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation 12 (26%) 19 (40%) 18 (38%) 19 (40%)
Lymph Node, Mesenteric (49) (47) (49) (50)
Atrophy 2 (4%)
Ectasia 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 3 (6%) 8 (17%) 9 (18%) 10 (20%)
Spleen (49) (49) (49) (49)
Hematopoietic Cell Proliferation 15 (31%) 16 (33%) 13 (27%) 11 (22%)
Hyperplasia, Lymphoid 8 (16%) 11 (22%) 8 (16%) 11 (22%)
Pigmentation 1 (2%) 1 (2%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 1 (2%)
Lymphoid Follicle, Hyperplasia 14 (29%) 12 (24%) 12 (24%) 13 (27%)
Red Pulp, Congestion 1 (2%)
Thymus (49) (49) (50) (48)
Atrophy 3 (6%) 6 (12%) 2 (4%) 5 (10%)
Hyperplasia, Lymphoid 3 (6%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (49)
Galactocele 1 (2%)
Hyperplasia 16 (32%) 10 (20%) 14 (29%) 24 (49%)
Skin (50) (50) (50) (50)
Edema 1 (2%) 1 (2%)
Epidermis, Hyperplasia 1 (2%)
Subcutaneous Tissue, Inflammation,
Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 10 (20%) 12 (24%) 10 (20%) 6 (12%)
Skeletal Muscle (1) (1) (2) (2)
Mineralization 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Peripheral Nerve (2) (2)
Atrophy 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%) 2 (4%) 3 (6%) 4 (8%)
Hyperplasia, Lymphoid 6 (12%) 6 (12%) 8 (16%) 8 (16%)
Infiltration Cellular, Histiocyte 1 (2%) 5 (10%) 1 (2%) 8 (16%)
Metaplasia, Osseous 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%) 3 (6%) 11 (22%)
Nose (50) (49) (50) (50)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Cataract 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Cornea, Hyperplasia 1 (2%)
Cornea, Mineralization 1 (2%)
Retina, Degeneration 1 (2%)
Harderian Gland (50) (50) (50) (50)
Hyperplasia 1 (2%)
Hyperplasia, Focal 2 (4%) 3 (6%) 2 (4%)
Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 6 (12%) 3 (6%)
Metaplasia, Osseous 1 (2%) 1 (2%) 1 (2%)
Nephropathy 21 (43%) 20 (40%) 17 (34%) 25 (50%)
Renal Tubule, Accumulation, Hyaline Droplet 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Edema 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 3 (6%) 4 (8%) 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 4 6 8
Moribund Sacrifice 1 3
Survivors
Natural Death 1
Terminal Sacrifice 44 44 42 46
Other 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (49) (47) (50)
Edema 3 (6%) 1 (2%) 3 (6%) 4 (8%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation 1 (2%)
Ulcer 1 (2%) 1 (2%)
Intestine Small, Jejunum (48) (47) (48) (50)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Intestine Small, Ileum (49) (46) (48) (49)
Hyperplasia, Lymphoid 1 (2%)
Liver (50) (50) (50) (50)
Basophilic Focus 1 (2%) 1 (2%) 1 (2%)
Clear Cell Focus 3 (6%) 3 (6%) 2 (4%) 3 (6%)
Cyst 1 (2%) 1 (2%)
Eosinophilic Focus 5 (10%) 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Mixed Cell 3 (6%) 1 (2%)
Mixed Cell Focus 3 (6%) 7 (14%) 2 (4%)
Necrosis, Focal 2 (4%) 3 (6%) 2 (4%)
Tension Lipidosis 1 (2%) 1 (2%)
Centrilobular, Necrosis 1 (2%)
Hepatocyte, Hypertrophy 1 (2%) 1 (2%)
Hepatocyte, Vacuolization Cytoplasmic 4 (8%) 5 (10%) 2 (4%)
Mesentery (4) (7) (2) (3)
Hemorrhage 1 (25%)
Fat, Necrosis 3 (75%) 3 (43%) 2 (100%) 2 (67%)
Pancreas (49) (49) (50) (50)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Hyperplasia, Focal 1 (2%)
Stomach, Forestomach (49) (50) (50) (50)
Diverticulum 2 (4%) 1 (2%) 1 (2%)
Erosion 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Chronic 2 (4%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Hyperplasia 3 (6%) 2 (4%) 4 (8%)
Stomach, Glandular (49) (50) (49) (50)
Erosion 2 (4%) 1 (2%) 1 (2%)
Glands, Hyperplasia 1 (2%)
Tooth (4) (3)
Inflammation, Chronic 3 (75%) 2 (67%)
Malformation 1 (25%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Inflammation, Chronic 2 (4%) 2 (4%) 1 (2%)
Mineralization 2 (4%)
Thrombosis 1 (2%)
Myocardium, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 2 (4%) 4 (8%) 6 (12%) 8 (16%)
Hyperplasia, Focal 3 (6%) 2 (4%) 1 (2%) 1 (2%)
Hypertrophy, Focal 17 (34%) 11 (22%) 10 (20%) 14 (28%)
Capsule, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 5 (10%)
Islets, Pancreatic (49) (49) (50) (50)
Hyperplasia 4 (8%) 2 (4%) 1 (2%)
Parathyroid Gland (47) (49) (49) (49)
Cyst 1 (2%) 1 (2%) 1 (2%)
Pituitary Gland (49) (48) (49) (50)
Pars Distalis, Cyst 1 (2%) 3 (6%) 3 (6%) 2 (4%)
Thyroid Gland (50) (50) (50) (50)
Follicle, Cyst 13 (26%) 13 (26%) 13 (26%) 14 (28%)
Follicular Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Atypia Cellular 1 (2%) 1 (2%)
Spermatocele 1 (2%) 1 (2%)
Preputial Gland (50) (50) (50) (50)
Cyst 29 (58%) 27 (54%) 31 (62%) 36 (72%)
Inflammation, Chronic 17 (34%) 19 (38%) 24 (48%) 23 (46%)
Seminal Vesicle (50) (50) (50) (50)
Degeneration 1 (2%)
Testes (50) (50) (50) (50)
Germinal Epithelium, Atrophy 3 (6%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hyperplasia 13 (26%) 15 (30%) 14 (28%) 15 (30%)
Lymph Node (2) (2) (1) (2)
Inguinal, Hyperplasia, Lymphoid 1 (50%)
Inguinal, Pigmentation 1 (50%)
Pancreatic, Hyperplasia, Lymphoid 1 (50%)
Lymph Node, Mandibular (48) (50) (48) (45)
Hematopoietic Cell Proliferation 2 (4%) 1 (2%)
Hyperplasia, Lymphoid 10 (21%) 8 (16%) 9 (19%) 12 (27%)
Pigmentation 10 (21%) 5 (10%) 7 (15%) 12 (27%)
Lymph Node, Mesenteric (49) (48) (48) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 4 (8%) 7 (15%) 4 (8%) 14 (28%)
Hyperplasia, Lymphoid 7 (14%) 4 (8%) 4 (8%) 7 (14%)
Spleen (49) (49) (50) (50)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 10 (20%) 14 (29%) 9 (18%) 12 (24%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Lymphoid Follicle, Atrophy 1 (2%) 1 (2%) 1 (2%)
Lymphoid Follicle, Hyperplasia 10 (20%) 8 (16%) 2 (4%) 7 (14%)
Thymus (48) (49) (45) (45)
Atrophy 7 (15%) 7 (14%) 5 (11%) 8 (18%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (49)
Cyst Epithelial Inclusion 1 (2%)
Edema 2 (4%)
Ulcer 1 (2%)
Epidermis, Hyperplasia 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 1 (2%)
Skeletal Muscle (1) (2) (1) (1)
Atrophy 1 (100%)
Necrosis 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Peripheral Nerve (2)
Atrophy 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 1 (2%) 1 (2%)
Hemorrhage 3 (6%) 2 (4%) 1 (2%) 5 (10%)
Hyperplasia, Lymphoid 3 (6%) 2 (4%) 6 (12%) 2 (4%)
Infiltration Cellular, Histiocyte 5 (10%) 6 (12%) 5 (10%) 11 (22%)
Metaplasia, Osseous 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 7 (14%) 3 (6%) 1 (2%) 9 (18%)
Bronchiole, Epithelium, Hyperplasia 1 (2%) 1 (2%)
Nose (50) (50) (50) (50)
Inflammation, Chronic 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 92013-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 4-METHYLIMIDAZOLE Date: 01/12/04
Route: DOSED FEED Time: 14:34:40
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 312 PPM 625 PPM 1250 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (50)
Cataract 1 (2%) 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Harderian Gland (50) (50) (50) (50)
Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 13 (26%) 12 (24%) 12 (24%) 7 (14%)
Hydronephrosis 1 (2%) 1 (2%)
Hyperplasia, Lymphoid 2 (4%) 2 (4%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Metaplasia, Osseous 2 (4%) 3 (6%) 2 (4%)
Mineralization 2 (4%)
Nephropathy 34 (68%) 40 (80%) 38 (76%) 35 (70%)
Renal Tubule, Necrosis 1 (2%)
Urinary Bladder (50) (49) (49) (50)
Edema 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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